Effect of Modified Roux-en-Y Gastric Bypass Surgery on GLP-1, GIP in Patients with Type 2 Diabetes Mellitus
The type 2 diabetes mellitus (T2DM) is one of the most serious diseases that threaten public health. Modified gastric bypass surgery has been applied to the treatment of T2DM patients in the 1990s, but the therapeutic mechanism to this function is still unclear. The aim of this study was to further...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2015/625196 |
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| author | Shao-Wei Xiong Jing Cao Xian-Ming Liu Xing-Ming Deng Zeng Liu Fang-Ting Zhang |
| author_facet | Shao-Wei Xiong Jing Cao Xian-Ming Liu Xing-Ming Deng Zeng Liu Fang-Ting Zhang |
| author_sort | Shao-Wei Xiong |
| collection | DOAJ |
| description | The type 2 diabetes mellitus (T2DM) is one of the most serious diseases that threaten public health. Modified gastric bypass surgery has been applied to the treatment of T2DM patients in the 1990s, but the therapeutic mechanism to this function is still unclear. The aim of this study was to further clarify the effect and the mechanism of modified gastric bypass surgery on glucose metabolism in patients with T2DM. In the study, the incretin indexes and blood glucose indexes were analyzed before surgery and 1 week and 1, 3, and 6 months after surgery. The results suggested that modified Roux-en-Y gastric bypass can promote GLP-1 secretion in patients with T2DM, while reducing the secretion of GIP. Thus it could effectively control blood glucose of patients with T2DM. |
| format | Article |
| id | doaj-art-475f86a30c5e4ab1b7a98a22223e3bcf |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-475f86a30c5e4ab1b7a98a22223e3bcf2025-02-03T07:26:04ZengWileyGastroenterology Research and Practice1687-61211687-630X2015-01-01201510.1155/2015/625196625196Effect of Modified Roux-en-Y Gastric Bypass Surgery on GLP-1, GIP in Patients with Type 2 Diabetes MellitusShao-Wei Xiong0Jing Cao1Xian-Ming Liu2Xing-Ming Deng3Zeng Liu4Fang-Ting Zhang5Department of General Surgery, Peking University Shenzhen Hospital, Shenzhen, Guangdong 518036, ChinaDepartment of General Surgery, Peking University Shenzhen Hospital, Shenzhen, Guangdong 518036, ChinaDepartment of General Surgery, Peking University Shenzhen Hospital, Shenzhen, Guangdong 518036, ChinaDepartment of General Surgery, Peking University Shenzhen Hospital, Shenzhen, Guangdong 518036, ChinaDepartment of General Surgery, Peking University Shenzhen Hospital, Shenzhen, Guangdong 518036, ChinaCentral Laboratory, Peking University Shenzhen Hospital, Shenzhen, Guangdong 518036, ChinaThe type 2 diabetes mellitus (T2DM) is one of the most serious diseases that threaten public health. Modified gastric bypass surgery has been applied to the treatment of T2DM patients in the 1990s, but the therapeutic mechanism to this function is still unclear. The aim of this study was to further clarify the effect and the mechanism of modified gastric bypass surgery on glucose metabolism in patients with T2DM. In the study, the incretin indexes and blood glucose indexes were analyzed before surgery and 1 week and 1, 3, and 6 months after surgery. The results suggested that modified Roux-en-Y gastric bypass can promote GLP-1 secretion in patients with T2DM, while reducing the secretion of GIP. Thus it could effectively control blood glucose of patients with T2DM.http://dx.doi.org/10.1155/2015/625196 |
| spellingShingle | Shao-Wei Xiong Jing Cao Xian-Ming Liu Xing-Ming Deng Zeng Liu Fang-Ting Zhang Effect of Modified Roux-en-Y Gastric Bypass Surgery on GLP-1, GIP in Patients with Type 2 Diabetes Mellitus Gastroenterology Research and Practice |
| title | Effect of Modified Roux-en-Y Gastric Bypass Surgery on GLP-1, GIP in Patients with Type 2 Diabetes Mellitus |
| title_full | Effect of Modified Roux-en-Y Gastric Bypass Surgery on GLP-1, GIP in Patients with Type 2 Diabetes Mellitus |
| title_fullStr | Effect of Modified Roux-en-Y Gastric Bypass Surgery on GLP-1, GIP in Patients with Type 2 Diabetes Mellitus |
| title_full_unstemmed | Effect of Modified Roux-en-Y Gastric Bypass Surgery on GLP-1, GIP in Patients with Type 2 Diabetes Mellitus |
| title_short | Effect of Modified Roux-en-Y Gastric Bypass Surgery on GLP-1, GIP in Patients with Type 2 Diabetes Mellitus |
| title_sort | effect of modified roux en y gastric bypass surgery on glp 1 gip in patients with type 2 diabetes mellitus |
| url | http://dx.doi.org/10.1155/2015/625196 |
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