Restenosis and Therapy
The vascular disease involves imbalanced function of the blood vessels. Risk factors playing a role in development of impaired vessel functions will be briefly discussed. In ischemia/reperfusion (I/R), ischemic hypoxia is one of the cardinal risk factors of restenosis. Various insults are shown to i...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Vascular Medicine |
| Online Access: | http://dx.doi.org/10.1155/2012/406236 |
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| _version_ | 1832550788426104832 |
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| author | Laszlo Denes Laszlo Entz Veronika Jancsik |
| author_facet | Laszlo Denes Laszlo Entz Veronika Jancsik |
| author_sort | Laszlo Denes |
| collection | DOAJ |
| description | The vascular disease involves imbalanced function of the blood vessels. Risk factors playing a role in development of impaired vessel functions will be briefly discussed. In ischemia/reperfusion (I/R), ischemic hypoxia is one of the cardinal risk factors of restenosis. Various insults are shown to initiate the phenotype switch of VSMCs. The pathological process, leading to activated inflammatory process, complement activation, and release of growth factors, initiate the proliferation of VSMCs in the media and cause luminal narrowing and impaired vascular function. The review summarizes the alteration process and demonstrates some of the clinical genetic background showing the role of complement and the genotypes of mannose-binding lectin (MBL2). Those could be useful markers of carotid restenosis after stent implantation. Gene therapy and therapeutic angiogenesis is proposed for therapy in restenosis. We suggest a drug candidate (iroxanadine), which ensures a noninvasive treatment by reverse regulation of the highly proliferating VSMCs and the disturbed function of ECs. |
| format | Article |
| id | doaj-art-475cff38212d4c41abbbeeb46aff629c |
| institution | Kabale University |
| issn | 2090-2824 2090-2832 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Vascular Medicine |
| spelling | doaj-art-475cff38212d4c41abbbeeb46aff629c2025-02-03T06:05:47ZengWileyInternational Journal of Vascular Medicine2090-28242090-28322012-01-01201210.1155/2012/406236406236Restenosis and TherapyLaszlo Denes0Laszlo Entz1Veronika Jancsik2Department of Pharmacology and Pharmacotherapy, Semmelweis University, Budapest 1089, HungaryDepartment of Vascular Surgery, Semmelweis University, Budapest 1122, HungaryDepartment of Anatomy and Histology, Faculty of Veterinary Science, Szent Istvan University, Budapest 1078, HungaryThe vascular disease involves imbalanced function of the blood vessels. Risk factors playing a role in development of impaired vessel functions will be briefly discussed. In ischemia/reperfusion (I/R), ischemic hypoxia is one of the cardinal risk factors of restenosis. Various insults are shown to initiate the phenotype switch of VSMCs. The pathological process, leading to activated inflammatory process, complement activation, and release of growth factors, initiate the proliferation of VSMCs in the media and cause luminal narrowing and impaired vascular function. The review summarizes the alteration process and demonstrates some of the clinical genetic background showing the role of complement and the genotypes of mannose-binding lectin (MBL2). Those could be useful markers of carotid restenosis after stent implantation. Gene therapy and therapeutic angiogenesis is proposed for therapy in restenosis. We suggest a drug candidate (iroxanadine), which ensures a noninvasive treatment by reverse regulation of the highly proliferating VSMCs and the disturbed function of ECs.http://dx.doi.org/10.1155/2012/406236 |
| spellingShingle | Laszlo Denes Laszlo Entz Veronika Jancsik Restenosis and Therapy International Journal of Vascular Medicine |
| title | Restenosis and Therapy |
| title_full | Restenosis and Therapy |
| title_fullStr | Restenosis and Therapy |
| title_full_unstemmed | Restenosis and Therapy |
| title_short | Restenosis and Therapy |
| title_sort | restenosis and therapy |
| url | http://dx.doi.org/10.1155/2012/406236 |
| work_keys_str_mv | AT laszlodenes restenosisandtherapy AT laszloentz restenosisandtherapy AT veronikajancsik restenosisandtherapy |