Effect of Continuous Positive Airway Pressure on Airway Inflammation and Oxidative Stress in Patients with Obstructive Sleep Apnea
Background. Airway inflammation and oxidative stress may be linked in obstructive sleep apnea (OSA) patients. We determined the effectiveness of continuous positive airway pressure (CPAP) therapy in reducing fractional exhaled nitric oxide (FeNO) and malondialdehyde (MDA) levels in OSA patients. Met...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2016-01-01
|
| Series: | Canadian Respiratory Journal |
| Online Access: | http://dx.doi.org/10.1155/2016/3107324 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832553939220824064 |
|---|---|
| author | Promsrisuk Tichanon Khrisanapant Wilaiwan Santamit Sopida Pasurivong Orapin Boonsawat Watchara Intarapoka Banjamas |
| author_facet | Promsrisuk Tichanon Khrisanapant Wilaiwan Santamit Sopida Pasurivong Orapin Boonsawat Watchara Intarapoka Banjamas |
| author_sort | Promsrisuk Tichanon |
| collection | DOAJ |
| description | Background. Airway inflammation and oxidative stress may be linked in obstructive sleep apnea (OSA) patients. We determined the effectiveness of continuous positive airway pressure (CPAP) therapy in reducing fractional exhaled nitric oxide (FeNO) and malondialdehyde (MDA) levels in OSA patients. Methods. Thirteen patients with OSA and 13 normal controls were recruited. FeNO and MDA levels were measured in the controls and in OSA patients before and after three months of CPAP therapy. Results. FeNO and MDA levels were higher in the patients compared to the age and gender matched controls (FeNO: 25.9 ± 5.0 versus 17.5 ± 5.9 ppb, P<0.001; MDA: 14.6 ± 7.8 versus 2.1 ± 0.3 μmol/L, P<0.001). FeNO and MDA levels were lower post-CPAP compared to pre-CPAP (FeNO: 25.9 ± 5.0 versus 17.0 ± 2.3 ppb, P<0.001; MDA: 14.6 ± 7.8 versus 10.0 ± 6.4 μmol/L, P<0.01). Apnea-hypopnea index (15.9 ± 6.6 versus 4.1 ± 2.1/h, P<0.001) and mean arterial pressure (P<0.01) decreased following CPAP treatment. Daytime mean SpO2 (P<0.05) increased. Conclusion. Our study demonstrates that CPAP therapy yields clinical benefits by reducing upper airway inflammation and oxidative stress in OSA patients. |
| format | Article |
| id | doaj-art-475c610a5d9b4c62a91acf2bbf18d20e |
| institution | Kabale University |
| issn | 1198-2241 1916-7245 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Respiratory Journal |
| spelling | doaj-art-475c610a5d9b4c62a91acf2bbf18d20e2025-02-03T05:52:46ZengWileyCanadian Respiratory Journal1198-22411916-72452016-01-01201610.1155/2016/31073243107324Effect of Continuous Positive Airway Pressure on Airway Inflammation and Oxidative Stress in Patients with Obstructive Sleep ApneaPromsrisuk Tichanon0Khrisanapant Wilaiwan1Santamit Sopida2Pasurivong Orapin3Boonsawat Watchara4Intarapoka Banjamas5Department of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, ThailandDepartment of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, ThailandDepartment of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, ThailandDepartment of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, ThailandDepartment of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, ThailandBumrungrad International Hospital, Bangkok 10110, ThailandBackground. Airway inflammation and oxidative stress may be linked in obstructive sleep apnea (OSA) patients. We determined the effectiveness of continuous positive airway pressure (CPAP) therapy in reducing fractional exhaled nitric oxide (FeNO) and malondialdehyde (MDA) levels in OSA patients. Methods. Thirteen patients with OSA and 13 normal controls were recruited. FeNO and MDA levels were measured in the controls and in OSA patients before and after three months of CPAP therapy. Results. FeNO and MDA levels were higher in the patients compared to the age and gender matched controls (FeNO: 25.9 ± 5.0 versus 17.5 ± 5.9 ppb, P<0.001; MDA: 14.6 ± 7.8 versus 2.1 ± 0.3 μmol/L, P<0.001). FeNO and MDA levels were lower post-CPAP compared to pre-CPAP (FeNO: 25.9 ± 5.0 versus 17.0 ± 2.3 ppb, P<0.001; MDA: 14.6 ± 7.8 versus 10.0 ± 6.4 μmol/L, P<0.01). Apnea-hypopnea index (15.9 ± 6.6 versus 4.1 ± 2.1/h, P<0.001) and mean arterial pressure (P<0.01) decreased following CPAP treatment. Daytime mean SpO2 (P<0.05) increased. Conclusion. Our study demonstrates that CPAP therapy yields clinical benefits by reducing upper airway inflammation and oxidative stress in OSA patients.http://dx.doi.org/10.1155/2016/3107324 |
| spellingShingle | Promsrisuk Tichanon Khrisanapant Wilaiwan Santamit Sopida Pasurivong Orapin Boonsawat Watchara Intarapoka Banjamas Effect of Continuous Positive Airway Pressure on Airway Inflammation and Oxidative Stress in Patients with Obstructive Sleep Apnea Canadian Respiratory Journal |
| title | Effect of Continuous Positive Airway Pressure on Airway Inflammation and Oxidative Stress in Patients with Obstructive Sleep Apnea |
| title_full | Effect of Continuous Positive Airway Pressure on Airway Inflammation and Oxidative Stress in Patients with Obstructive Sleep Apnea |
| title_fullStr | Effect of Continuous Positive Airway Pressure on Airway Inflammation and Oxidative Stress in Patients with Obstructive Sleep Apnea |
| title_full_unstemmed | Effect of Continuous Positive Airway Pressure on Airway Inflammation and Oxidative Stress in Patients with Obstructive Sleep Apnea |
| title_short | Effect of Continuous Positive Airway Pressure on Airway Inflammation and Oxidative Stress in Patients with Obstructive Sleep Apnea |
| title_sort | effect of continuous positive airway pressure on airway inflammation and oxidative stress in patients with obstructive sleep apnea |
| url | http://dx.doi.org/10.1155/2016/3107324 |
| work_keys_str_mv | AT promsrisuktichanon effectofcontinuouspositiveairwaypressureonairwayinflammationandoxidativestressinpatientswithobstructivesleepapnea AT khrisanapantwilaiwan effectofcontinuouspositiveairwaypressureonairwayinflammationandoxidativestressinpatientswithobstructivesleepapnea AT santamitsopida effectofcontinuouspositiveairwaypressureonairwayinflammationandoxidativestressinpatientswithobstructivesleepapnea AT pasurivongorapin effectofcontinuouspositiveairwaypressureonairwayinflammationandoxidativestressinpatientswithobstructivesleepapnea AT boonsawatwatchara effectofcontinuouspositiveairwaypressureonairwayinflammationandoxidativestressinpatientswithobstructivesleepapnea AT intarapokabanjamas effectofcontinuouspositiveairwaypressureonairwayinflammationandoxidativestressinpatientswithobstructivesleepapnea |