Tight junction proteins in glial tumors development and progression
Tight junctions form a paracellular barrier in epithelial and endothelial cells, and they regulate the diffusion of fluids, molecules, and the penetration of cells across tissue compartments. Tight junctions are composed of a group of integral membrane proteins, which include the claudin family, tig...
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Cellular Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fncel.2025.1541885/full |
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| author | Jakub Moskal Slawomir Michalak Slawomir Michalak |
| author_facet | Jakub Moskal Slawomir Michalak Slawomir Michalak |
| author_sort | Jakub Moskal |
| collection | DOAJ |
| description | Tight junctions form a paracellular barrier in epithelial and endothelial cells, and they regulate the diffusion of fluids, molecules, and the penetration of cells across tissue compartments. Tight junctions are composed of a group of integral membrane proteins, which include the claudin family, tight junction-associated Marvel protein family, junctional adhesion molecule family, and proteins that anchor the cytoskeleton, such as zonula occludens proteins and the cingulin family. Several factors, such as neurotransmitters or cytokines, and processes like ischemia/hypoxia, inflammation, tumorigenesis, phosphorylation/dephosphorylation, ubiquitination, and palmitoylation, regulate tight junction proteins. Claudins are involved in tumorigenesis processes that lead to glioma formation. In gliomas, there is a noticeable dysregulation of claudins, occludin, and zonula occludens-1 abundance, and their dislocation has been observed. The weakening of intercellular adhesion and cell detachment is responsible for glioma infiltration into surrounding tissues. Furthermore, the paracellular permeability of the blood–brain barrier, formed with the involvement of tight junction proteins, influences the development of peritumoral edema – and, simultaneously, the rate of drug delivery to the glial tumor. Understanding the junctional and paracellular environments in brain tumors is crucial to predicting glial tumor progression and the feasibility of chemotherapeutic drug delivery. This knowledge may also illuminate differences between high and low-grade gliomas. |
| format | Article |
| id | doaj-art-4758d77af178402a80b7a3c7952922d8 |
| institution | Kabale University |
| issn | 1662-5102 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj-art-4758d77af178402a80b7a3c7952922d82025-02-03T06:33:49ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022025-02-011910.3389/fncel.2025.15418851541885Tight junction proteins in glial tumors development and progressionJakub Moskal0Slawomir Michalak1Slawomir Michalak2Department of Neurosurgery and Neurotraumatology, Poznan University of Medical Sciences, Poznan, PolandDepartment of Neurosurgery and Neurotraumatology, Poznan University of Medical Sciences, Poznan, PolandDepartment of Neurochemistry and Neuropathology, Poznan University of Medical Sciences, Poznan, PolandTight junctions form a paracellular barrier in epithelial and endothelial cells, and they regulate the diffusion of fluids, molecules, and the penetration of cells across tissue compartments. Tight junctions are composed of a group of integral membrane proteins, which include the claudin family, tight junction-associated Marvel protein family, junctional adhesion molecule family, and proteins that anchor the cytoskeleton, such as zonula occludens proteins and the cingulin family. Several factors, such as neurotransmitters or cytokines, and processes like ischemia/hypoxia, inflammation, tumorigenesis, phosphorylation/dephosphorylation, ubiquitination, and palmitoylation, regulate tight junction proteins. Claudins are involved in tumorigenesis processes that lead to glioma formation. In gliomas, there is a noticeable dysregulation of claudins, occludin, and zonula occludens-1 abundance, and their dislocation has been observed. The weakening of intercellular adhesion and cell detachment is responsible for glioma infiltration into surrounding tissues. Furthermore, the paracellular permeability of the blood–brain barrier, formed with the involvement of tight junction proteins, influences the development of peritumoral edema – and, simultaneously, the rate of drug delivery to the glial tumor. Understanding the junctional and paracellular environments in brain tumors is crucial to predicting glial tumor progression and the feasibility of chemotherapeutic drug delivery. This knowledge may also illuminate differences between high and low-grade gliomas.https://www.frontiersin.org/articles/10.3389/fncel.2025.1541885/fulltight junctionclaudin familyTJ-associated Marvel protein familyjunctional adhesion molecule familyzonula occludens proteinglial tumors |
| spellingShingle | Jakub Moskal Slawomir Michalak Slawomir Michalak Tight junction proteins in glial tumors development and progression Frontiers in Cellular Neuroscience tight junction claudin family TJ-associated Marvel protein family junctional adhesion molecule family zonula occludens protein glial tumors |
| title | Tight junction proteins in glial tumors development and progression |
| title_full | Tight junction proteins in glial tumors development and progression |
| title_fullStr | Tight junction proteins in glial tumors development and progression |
| title_full_unstemmed | Tight junction proteins in glial tumors development and progression |
| title_short | Tight junction proteins in glial tumors development and progression |
| title_sort | tight junction proteins in glial tumors development and progression |
| topic | tight junction claudin family TJ-associated Marvel protein family junctional adhesion molecule family zonula occludens protein glial tumors |
| url | https://www.frontiersin.org/articles/10.3389/fncel.2025.1541885/full |
| work_keys_str_mv | AT jakubmoskal tightjunctionproteinsinglialtumorsdevelopmentandprogression AT slawomirmichalak tightjunctionproteinsinglialtumorsdevelopmentandprogression AT slawomirmichalak tightjunctionproteinsinglialtumorsdevelopmentandprogression |