The NT-ProBNP Test in Subjects with End-Stage Renal Disease on Hemodialysis Presenting with Acute Dyspnea: Is Knowing Worth the Cost?
Background. The NT-ProBNP/BNP test has been validated as a marker for determining the etiology of acute dyspnea. In the setting of end-stage renal disease on hemodialysis (ESRD on HD), the utility of the NT-ProBNP/BNP test has not been validated. This study examines the clinical utility of the NT-Pr...
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Wiley
2013-01-01
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| Series: | Emergency Medicine International |
| Online Access: | http://dx.doi.org/10.1155/2013/836497 |
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| author | Shaffer R. S. Mok Jose Avila Barry Milcarek Richard Kasama |
| author_facet | Shaffer R. S. Mok Jose Avila Barry Milcarek Richard Kasama |
| author_sort | Shaffer R. S. Mok |
| collection | DOAJ |
| description | Background. The NT-ProBNP/BNP test has been validated as a marker for determining the etiology of acute dyspnea. In the setting of end-stage renal disease on hemodialysis (ESRD on HD), the utility of the NT-ProBNP/BNP test has not been validated. This study examines the clinical utility of the NT-ProBNP test in the setting of ESRD on HD patients presenting with acute dyspnea. Methods. A retrospective case series of 250 subjects were admitted to Cooper University Hospital, 07/2010-03/2011, with ESRD and HD presenting with dyspnea. The incidences of echocardiography, cardiology consultation, and NT-ProBNP elevated and normal were examined. Correlation coefficients were calculated for NT-ProBNP with age (years), estimated dry weight (kg), amount of fluid removed (L), and ejection fraction (EF in %) among other echocardiography parameters. Results. Of the total sample 235 patients had NT-ProBNP levels performed. Cardiology consults were placed in 68.8% and 58% who underwent echocardiography. Of those for whom an echocardiography was performed estimated mean EFs of 54.6%, 50.8%, and 61.7% were observed among the NT-ProBNP elevated group, normal group, and no NT-ProBNP group, respectively. No differences were detected in all other echocardiography measurements.
No correlation was observed between NT-ProBNP and age (), baseline EDW (), amount of fluid removed (), or EF (). Conclusion. In the setting of ESRD on HD, the NT-ProBNP test has no clinical utility in determining the etiology of acute dyspnea. This can be demonstrated through echocardiographic and therapeutic parameters measured in this study. |
| format | Article |
| id | doaj-art-474ab04547a543b8a182c067d6947faf |
| institution | Kabale University |
| issn | 2090-2840 2090-2859 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Emergency Medicine International |
| spelling | doaj-art-474ab04547a543b8a182c067d6947faf2025-02-03T01:08:59ZengWileyEmergency Medicine International2090-28402090-28592013-01-01201310.1155/2013/836497836497The NT-ProBNP Test in Subjects with End-Stage Renal Disease on Hemodialysis Presenting with Acute Dyspnea: Is Knowing Worth the Cost?Shaffer R. S. Mok0Jose Avila1Barry Milcarek2Richard Kasama3Division of Internal Medicine, Department of Medicine, Cooper University Hospital, 1 Cooper Plaza, 401 Haddon Avenue, 3rd Floor, Camden, NJ 08103, USADivision of Nephrology, Department of Internal Medicine, Cooper University Hospital, 1 Cooper Plaza, 401 Haddon Avenue, 3rd Floor, Camden, NJ 08103, USADivision of Nephrology, Department of Internal Medicine, Cooper University Hospital, 1 Cooper Plaza, 401 Haddon Avenue, 3rd Floor, Camden, NJ 08103, USADivision of Nephrology, Department of Internal Medicine, Cooper University Hospital, 1 Cooper Plaza, 401 Haddon Avenue, 3rd Floor, Camden, NJ 08103, USABackground. The NT-ProBNP/BNP test has been validated as a marker for determining the etiology of acute dyspnea. In the setting of end-stage renal disease on hemodialysis (ESRD on HD), the utility of the NT-ProBNP/BNP test has not been validated. This study examines the clinical utility of the NT-ProBNP test in the setting of ESRD on HD patients presenting with acute dyspnea. Methods. A retrospective case series of 250 subjects were admitted to Cooper University Hospital, 07/2010-03/2011, with ESRD and HD presenting with dyspnea. The incidences of echocardiography, cardiology consultation, and NT-ProBNP elevated and normal were examined. Correlation coefficients were calculated for NT-ProBNP with age (years), estimated dry weight (kg), amount of fluid removed (L), and ejection fraction (EF in %) among other echocardiography parameters. Results. Of the total sample 235 patients had NT-ProBNP levels performed. Cardiology consults were placed in 68.8% and 58% who underwent echocardiography. Of those for whom an echocardiography was performed estimated mean EFs of 54.6%, 50.8%, and 61.7% were observed among the NT-ProBNP elevated group, normal group, and no NT-ProBNP group, respectively. No differences were detected in all other echocardiography measurements. No correlation was observed between NT-ProBNP and age (), baseline EDW (), amount of fluid removed (), or EF (). Conclusion. In the setting of ESRD on HD, the NT-ProBNP test has no clinical utility in determining the etiology of acute dyspnea. This can be demonstrated through echocardiographic and therapeutic parameters measured in this study.http://dx.doi.org/10.1155/2013/836497 |
| spellingShingle | Shaffer R. S. Mok Jose Avila Barry Milcarek Richard Kasama The NT-ProBNP Test in Subjects with End-Stage Renal Disease on Hemodialysis Presenting with Acute Dyspnea: Is Knowing Worth the Cost? Emergency Medicine International |
| title | The NT-ProBNP Test in Subjects with End-Stage Renal Disease on Hemodialysis Presenting with Acute Dyspnea: Is Knowing Worth the Cost? |
| title_full | The NT-ProBNP Test in Subjects with End-Stage Renal Disease on Hemodialysis Presenting with Acute Dyspnea: Is Knowing Worth the Cost? |
| title_fullStr | The NT-ProBNP Test in Subjects with End-Stage Renal Disease on Hemodialysis Presenting with Acute Dyspnea: Is Knowing Worth the Cost? |
| title_full_unstemmed | The NT-ProBNP Test in Subjects with End-Stage Renal Disease on Hemodialysis Presenting with Acute Dyspnea: Is Knowing Worth the Cost? |
| title_short | The NT-ProBNP Test in Subjects with End-Stage Renal Disease on Hemodialysis Presenting with Acute Dyspnea: Is Knowing Worth the Cost? |
| title_sort | nt probnp test in subjects with end stage renal disease on hemodialysis presenting with acute dyspnea is knowing worth the cost |
| url | http://dx.doi.org/10.1155/2013/836497 |
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