Revisiting Apathy in Alzheimer’s Disease: From Conceptualization to Therapeutic Approaches
Apathy is a neurobehavioral syndrome characterized by impaired motivation for goal-directed behaviors and cognitive activity, alongside blunted affect. Apathy is a common neuropsychiatric syndrome in Alzheimer’s disease (AD), with a 5-year prevalence over 70%. Apathy also serves as a prognostic indi...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Behavioural Neurology |
| Online Access: | http://dx.doi.org/10.1155/2021/6319826 |
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| author | Antonio L. Teixeira Mitzi M. Gonzales Leonardo Cruz de Souza Sara L. Weisenbach |
| author_facet | Antonio L. Teixeira Mitzi M. Gonzales Leonardo Cruz de Souza Sara L. Weisenbach |
| author_sort | Antonio L. Teixeira |
| collection | DOAJ |
| description | Apathy is a neurobehavioral syndrome characterized by impaired motivation for goal-directed behaviors and cognitive activity, alongside blunted affect. Apathy is a common neuropsychiatric syndrome in Alzheimer’s disease (AD), with a 5-year prevalence over 70%. Apathy also serves as a prognostic indicator, correlating with the progression of AD. Despite advances in its conceptualization and understanding of its neural basis, there is very limited empirical evidence to support the available strategies for the treatment of apathy in AD. Given its complex pathophysiology, including distinct substrates for different apathy dimensions (affective, cognitive, and behavioral), it is unlikely that a single pharmacological or nonpharmacological strategy will be effective for all cases of apathy in AD. High-quality evidence research is needed to better understand the role of specific strategies aiming at a personalized approach. |
| format | Article |
| id | doaj-art-47485c66a95a45e7aa882985416c2605 |
| institution | Kabale University |
| issn | 0953-4180 1875-8584 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Behavioural Neurology |
| spelling | doaj-art-47485c66a95a45e7aa882985416c26052025-02-03T06:12:00ZengWileyBehavioural Neurology0953-41801875-85842021-01-01202110.1155/2021/63198266319826Revisiting Apathy in Alzheimer’s Disease: From Conceptualization to Therapeutic ApproachesAntonio L. Teixeira0Mitzi M. Gonzales1Leonardo Cruz de Souza2Sara L. Weisenbach3Neuropsychiatry Program, UT Health Science Center at Houston, USAGlenn Biggs Institute for Alzheimer’s & Neurodegenerative Diseases, UT Health Science Center at San Antonio, USAPrograma de Pós-Graduação em Neurociências, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, BrazilDepartment of Psychiatry & Behavioral Health, Stony Brook University, Stony Brook, New York, USAApathy is a neurobehavioral syndrome characterized by impaired motivation for goal-directed behaviors and cognitive activity, alongside blunted affect. Apathy is a common neuropsychiatric syndrome in Alzheimer’s disease (AD), with a 5-year prevalence over 70%. Apathy also serves as a prognostic indicator, correlating with the progression of AD. Despite advances in its conceptualization and understanding of its neural basis, there is very limited empirical evidence to support the available strategies for the treatment of apathy in AD. Given its complex pathophysiology, including distinct substrates for different apathy dimensions (affective, cognitive, and behavioral), it is unlikely that a single pharmacological or nonpharmacological strategy will be effective for all cases of apathy in AD. High-quality evidence research is needed to better understand the role of specific strategies aiming at a personalized approach.http://dx.doi.org/10.1155/2021/6319826 |
| spellingShingle | Antonio L. Teixeira Mitzi M. Gonzales Leonardo Cruz de Souza Sara L. Weisenbach Revisiting Apathy in Alzheimer’s Disease: From Conceptualization to Therapeutic Approaches Behavioural Neurology |
| title | Revisiting Apathy in Alzheimer’s Disease: From Conceptualization to Therapeutic Approaches |
| title_full | Revisiting Apathy in Alzheimer’s Disease: From Conceptualization to Therapeutic Approaches |
| title_fullStr | Revisiting Apathy in Alzheimer’s Disease: From Conceptualization to Therapeutic Approaches |
| title_full_unstemmed | Revisiting Apathy in Alzheimer’s Disease: From Conceptualization to Therapeutic Approaches |
| title_short | Revisiting Apathy in Alzheimer’s Disease: From Conceptualization to Therapeutic Approaches |
| title_sort | revisiting apathy in alzheimer s disease from conceptualization to therapeutic approaches |
| url | http://dx.doi.org/10.1155/2021/6319826 |
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