Antibacterial Efficacy of Iron-Oxide Nanoparticles against Biofilms on Different Biomaterial Surfaces
Biofilm growth on the implant surface is the number one cause of the failure of the implants. Biofilms on implant surfaces are hard to eliminate by antibiotics due to the protection offered by the exopolymeric substances that embed the organisms in a matrix, impenetrable for most antibiotics and imm...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | International Journal of Biomaterials |
| Online Access: | http://dx.doi.org/10.1155/2014/716080 |
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| author | Monica Thukkaram Soundarya Sitaram Sathish kumar Kannaiyan Guruprakash Subbiahdoss |
| author_facet | Monica Thukkaram Soundarya Sitaram Sathish kumar Kannaiyan Guruprakash Subbiahdoss |
| author_sort | Monica Thukkaram |
| collection | DOAJ |
| description | Biofilm growth on the implant surface is the number one cause of the failure of the implants. Biofilms on implant surfaces are hard to eliminate by antibiotics due to the protection offered by the exopolymeric substances that embed the organisms in a matrix, impenetrable for most antibiotics and immune cells. Application of metals in nanoscale is considered to resolve biofilm formation. Here we studied the effect of iron-oxide nanoparticles over biofilm formation on different biomaterial surfaces and pluronic coated surfaces. Bacterial adhesion for 30 min showed significant reduction in bacterial adhesion on pluronic coated surfaces compared to other surfaces. Subsequently, bacteria were allowed to grow for 24 h in the presence of different concentrations of iron-oxide nanoparticles. A significant reduction in biofilm growth was observed in the presence of the highest concentration of iron-oxide nanoparticles on pluronic coated surfaces compared to other surfaces. Therefore, combination of polymer brush coating and iron-oxide nanoparticles could show a significant reduction in biofilm formation. |
| format | Article |
| id | doaj-art-4742c54741244c1ca2959ba432098c45 |
| institution | Kabale University |
| issn | 1687-8787 1687-8795 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Biomaterials |
| spelling | doaj-art-4742c54741244c1ca2959ba432098c452025-02-03T01:10:14ZengWileyInternational Journal of Biomaterials1687-87871687-87952014-01-01201410.1155/2014/716080716080Antibacterial Efficacy of Iron-Oxide Nanoparticles against Biofilms on Different Biomaterial SurfacesMonica Thukkaram0Soundarya Sitaram1Sathish kumar Kannaiyan2Guruprakash Subbiahdoss3Department of Biomedical Engineering, SSN College of Engineering, Old Mahabalipuram Road, Kalavakkam, Tamil Nadu 603110, IndiaDepartment of Biomedical Engineering, SSN College of Engineering, Old Mahabalipuram Road, Kalavakkam, Tamil Nadu 603110, IndiaDepartment of Chemical Engineering, SSN College of Engineering, Old Mahabalipuram Road, Kalavakkam, Tamil Nadu 603110, IndiaDepartment of Biomedical Engineering, SSN College of Engineering, Old Mahabalipuram Road, Kalavakkam, Tamil Nadu 603110, IndiaBiofilm growth on the implant surface is the number one cause of the failure of the implants. Biofilms on implant surfaces are hard to eliminate by antibiotics due to the protection offered by the exopolymeric substances that embed the organisms in a matrix, impenetrable for most antibiotics and immune cells. Application of metals in nanoscale is considered to resolve biofilm formation. Here we studied the effect of iron-oxide nanoparticles over biofilm formation on different biomaterial surfaces and pluronic coated surfaces. Bacterial adhesion for 30 min showed significant reduction in bacterial adhesion on pluronic coated surfaces compared to other surfaces. Subsequently, bacteria were allowed to grow for 24 h in the presence of different concentrations of iron-oxide nanoparticles. A significant reduction in biofilm growth was observed in the presence of the highest concentration of iron-oxide nanoparticles on pluronic coated surfaces compared to other surfaces. Therefore, combination of polymer brush coating and iron-oxide nanoparticles could show a significant reduction in biofilm formation.http://dx.doi.org/10.1155/2014/716080 |
| spellingShingle | Monica Thukkaram Soundarya Sitaram Sathish kumar Kannaiyan Guruprakash Subbiahdoss Antibacterial Efficacy of Iron-Oxide Nanoparticles against Biofilms on Different Biomaterial Surfaces International Journal of Biomaterials |
| title | Antibacterial Efficacy of Iron-Oxide Nanoparticles against Biofilms on Different Biomaterial Surfaces |
| title_full | Antibacterial Efficacy of Iron-Oxide Nanoparticles against Biofilms on Different Biomaterial Surfaces |
| title_fullStr | Antibacterial Efficacy of Iron-Oxide Nanoparticles against Biofilms on Different Biomaterial Surfaces |
| title_full_unstemmed | Antibacterial Efficacy of Iron-Oxide Nanoparticles against Biofilms on Different Biomaterial Surfaces |
| title_short | Antibacterial Efficacy of Iron-Oxide Nanoparticles against Biofilms on Different Biomaterial Surfaces |
| title_sort | antibacterial efficacy of iron oxide nanoparticles against biofilms on different biomaterial surfaces |
| url | http://dx.doi.org/10.1155/2014/716080 |
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