Endoscopic Submucosal Single- or Multi-tunnel Dissection for Near-Circumferential and Circumferential Superficial Esophageal Neoplastic Lesions
This study reports the outcomes of endoscopic submucosal single-tunnel dissection or endoscopic submucosal multi-tunnel dissection for the treatment of esophageal neoplastic lesions of at least three-quarters of the esophageal circumference, including circumferential superficial esophageal neoplasti...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2019/2943232 |
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| author | Lin-Lin Zhu Jun-Chao Wu Yi-Ping Wang Du He Wen-Yan Zhang Tao Gan Jin-Lin Yang |
| author_facet | Lin-Lin Zhu Jun-Chao Wu Yi-Ping Wang Du He Wen-Yan Zhang Tao Gan Jin-Lin Yang |
| author_sort | Lin-Lin Zhu |
| collection | DOAJ |
| description | This study reports the outcomes of endoscopic submucosal single-tunnel dissection or endoscopic submucosal multi-tunnel dissection for the treatment of esophageal neoplastic lesions of at least three-quarters of the esophageal circumference, including circumferential superficial esophageal neoplastic lesions. From July 2014 to February 2018, a total of 124 lesions underwent endoscopic submucosal tunnel dissection at our hospital. One to four submucosal tunnels were created in the oral to anal direction. Of the 124 lesions, there were 83 noncomplete circumferential lesions and 41 circumferential lesions. Endoscopic submucosal single-tunnel dissection was performed in 54 patients, two-tunnel dissection in 43 patients, three-tunnel dissection in 19 patients, and four-tunnel dissection in 8 patients. The mean dissection speed was 22.8±12.7 mm2/min. En bloc dissection was achieved in all lesions, and the R0 resection rate was 70.2 percent. No matter how large the lesion area was, there were no significant differences in the dissection speed and the R0 resection rate when lesions were at least three-quarters of the esophageal circumference. Esophageal stricture was observed in 54 patients and was relieved by placement of a retrievable metal stent or by endoscopic water balloon dilation. No recurrence was noted after 19.1±12.4 months of follow-up. Our large sample size study showed that endoscopic submucosal tunnel dissection showed effectiveness and safety for the treatment of large superficial esophageal neoplastic lesions at least three-quarters of the esophageal circumference, including circumferential superficial esophageal neoplastic lesions. |
| format | Article |
| id | doaj-art-4719aa21c74f4538a35dbac9fc644d51 |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-4719aa21c74f4538a35dbac9fc644d512025-02-03T00:59:16ZengWileyGastroenterology Research and Practice1687-61211687-630X2019-01-01201910.1155/2019/29432322943232Endoscopic Submucosal Single- or Multi-tunnel Dissection for Near-Circumferential and Circumferential Superficial Esophageal Neoplastic LesionsLin-Lin Zhu0Jun-Chao Wu1Yi-Ping Wang2Du He3Wen-Yan Zhang4Tao Gan5Jin-Lin Yang6Department of International Medical Center, West China Hospital of Sichuan University, No. 37 Guo Xue Alley, Chengdu, 610041 Sichuan, ChinaDepartment of Gastroenterology and Hepatology, West China Hospital of Sichuan University, No. 37 Guo Xue Alley, Chengdu, 610041 Sichuan, ChinaDepartment of Gastroenterology and Hepatology, West China Hospital of Sichuan University, No. 37 Guo Xue Alley, Chengdu, 610041 Sichuan, ChinaDepartment of Pathology, West China Hospital of Sichuan University, No. 37 Guo Xue Alley, Chengdu, 610041 Sichuan, ChinaDepartment of Pathology, West China Hospital of Sichuan University, No. 37 Guo Xue Alley, Chengdu, 610041 Sichuan, ChinaDepartment of Gastroenterology and Hepatology, West China Hospital of Sichuan University, No. 37 Guo Xue Alley, Chengdu, 610041 Sichuan, ChinaDepartment of Gastroenterology and Hepatology, West China Hospital of Sichuan University, No. 37 Guo Xue Alley, Chengdu, 610041 Sichuan, ChinaThis study reports the outcomes of endoscopic submucosal single-tunnel dissection or endoscopic submucosal multi-tunnel dissection for the treatment of esophageal neoplastic lesions of at least three-quarters of the esophageal circumference, including circumferential superficial esophageal neoplastic lesions. From July 2014 to February 2018, a total of 124 lesions underwent endoscopic submucosal tunnel dissection at our hospital. One to four submucosal tunnels were created in the oral to anal direction. Of the 124 lesions, there were 83 noncomplete circumferential lesions and 41 circumferential lesions. Endoscopic submucosal single-tunnel dissection was performed in 54 patients, two-tunnel dissection in 43 patients, three-tunnel dissection in 19 patients, and four-tunnel dissection in 8 patients. The mean dissection speed was 22.8±12.7 mm2/min. En bloc dissection was achieved in all lesions, and the R0 resection rate was 70.2 percent. No matter how large the lesion area was, there were no significant differences in the dissection speed and the R0 resection rate when lesions were at least three-quarters of the esophageal circumference. Esophageal stricture was observed in 54 patients and was relieved by placement of a retrievable metal stent or by endoscopic water balloon dilation. No recurrence was noted after 19.1±12.4 months of follow-up. Our large sample size study showed that endoscopic submucosal tunnel dissection showed effectiveness and safety for the treatment of large superficial esophageal neoplastic lesions at least three-quarters of the esophageal circumference, including circumferential superficial esophageal neoplastic lesions.http://dx.doi.org/10.1155/2019/2943232 |
| spellingShingle | Lin-Lin Zhu Jun-Chao Wu Yi-Ping Wang Du He Wen-Yan Zhang Tao Gan Jin-Lin Yang Endoscopic Submucosal Single- or Multi-tunnel Dissection for Near-Circumferential and Circumferential Superficial Esophageal Neoplastic Lesions Gastroenterology Research and Practice |
| title | Endoscopic Submucosal Single- or Multi-tunnel Dissection for Near-Circumferential and Circumferential Superficial Esophageal Neoplastic Lesions |
| title_full | Endoscopic Submucosal Single- or Multi-tunnel Dissection for Near-Circumferential and Circumferential Superficial Esophageal Neoplastic Lesions |
| title_fullStr | Endoscopic Submucosal Single- or Multi-tunnel Dissection for Near-Circumferential and Circumferential Superficial Esophageal Neoplastic Lesions |
| title_full_unstemmed | Endoscopic Submucosal Single- or Multi-tunnel Dissection for Near-Circumferential and Circumferential Superficial Esophageal Neoplastic Lesions |
| title_short | Endoscopic Submucosal Single- or Multi-tunnel Dissection for Near-Circumferential and Circumferential Superficial Esophageal Neoplastic Lesions |
| title_sort | endoscopic submucosal single or multi tunnel dissection for near circumferential and circumferential superficial esophageal neoplastic lesions |
| url | http://dx.doi.org/10.1155/2019/2943232 |
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