Co-Amoxiclav Induced Immune Haemolytic Anaemia: A Case Report
Drug-induced immune haemolytic anaemia (DIIHA) is extremely rare. We herein report a case of DIIHA due to co-amoxiclav. A 53-year-old male being treated for left-sided pyelonephritis with intravenous co-amoxiclav developed symptoms and signs of anaemia on the third day of treatment. He was found to...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2020/9841097 |
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| author | H. G. C. S. Karunathilaka D. P. Chandrasiri P. Ranasinghe V. Ratnamalala A. H. N. Fernando |
| author_facet | H. G. C. S. Karunathilaka D. P. Chandrasiri P. Ranasinghe V. Ratnamalala A. H. N. Fernando |
| author_sort | H. G. C. S. Karunathilaka |
| collection | DOAJ |
| description | Drug-induced immune haemolytic anaemia (DIIHA) is extremely rare. We herein report a case of DIIHA due to co-amoxiclav. A 53-year-old male being treated for left-sided pyelonephritis with intravenous co-amoxiclav developed symptoms and signs of anaemia on the third day of treatment. He was found to have evidence of haemolysis with a positive Coombs test and IgG antibodies and C3d. Co-amoxiclav was identified as the probable culprit, using the Naranjo adverse drug reaction probability scale. Upon discontinuation of the drug and blood transfusion, the patient’s haematological parameters stabilised. Steroids were not required in the treatment. Diagnosis of DIIHA is made through a history of intake of co-amoxiclav, clinical and laboratory features of haemolysis, and a positive Coombs test. An autoantibody screen is most commonly negative. It is essential for clinicians to be aware about this rare complication caused by commonly prescribed drugs and be able to accurately diagnose and initiate treatment. |
| format | Article |
| id | doaj-art-46fc03ae4ca0430a8a323c6bc5bdfa50 |
| institution | Kabale University |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-46fc03ae4ca0430a8a323c6bc5bdfa502025-02-03T01:27:04ZengWileyCase Reports in Hematology2090-65602090-65792020-01-01202010.1155/2020/98410979841097Co-Amoxiclav Induced Immune Haemolytic Anaemia: A Case ReportH. G. C. S. Karunathilaka0D. P. Chandrasiri1P. Ranasinghe2V. Ratnamalala3A. H. N. Fernando4National Hospital of Sri Lanka, Colombo, Sri LankaNational Hospital of Sri Lanka, Colombo, Sri LankaDepartment of Pharmacology, Faculty of Medicine, University of Colombo, Colombo, Sri LankaNational Hospital of Sri Lanka, Colombo, Sri LankaNational Hospital of Sri Lanka, Colombo, Sri LankaDrug-induced immune haemolytic anaemia (DIIHA) is extremely rare. We herein report a case of DIIHA due to co-amoxiclav. A 53-year-old male being treated for left-sided pyelonephritis with intravenous co-amoxiclav developed symptoms and signs of anaemia on the third day of treatment. He was found to have evidence of haemolysis with a positive Coombs test and IgG antibodies and C3d. Co-amoxiclav was identified as the probable culprit, using the Naranjo adverse drug reaction probability scale. Upon discontinuation of the drug and blood transfusion, the patient’s haematological parameters stabilised. Steroids were not required in the treatment. Diagnosis of DIIHA is made through a history of intake of co-amoxiclav, clinical and laboratory features of haemolysis, and a positive Coombs test. An autoantibody screen is most commonly negative. It is essential for clinicians to be aware about this rare complication caused by commonly prescribed drugs and be able to accurately diagnose and initiate treatment.http://dx.doi.org/10.1155/2020/9841097 |
| spellingShingle | H. G. C. S. Karunathilaka D. P. Chandrasiri P. Ranasinghe V. Ratnamalala A. H. N. Fernando Co-Amoxiclav Induced Immune Haemolytic Anaemia: A Case Report Case Reports in Hematology |
| title | Co-Amoxiclav Induced Immune Haemolytic Anaemia: A Case Report |
| title_full | Co-Amoxiclav Induced Immune Haemolytic Anaemia: A Case Report |
| title_fullStr | Co-Amoxiclav Induced Immune Haemolytic Anaemia: A Case Report |
| title_full_unstemmed | Co-Amoxiclav Induced Immune Haemolytic Anaemia: A Case Report |
| title_short | Co-Amoxiclav Induced Immune Haemolytic Anaemia: A Case Report |
| title_sort | co amoxiclav induced immune haemolytic anaemia a case report |
| url | http://dx.doi.org/10.1155/2020/9841097 |
| work_keys_str_mv | AT hgcskarunathilaka coamoxiclavinducedimmunehaemolyticanaemiaacasereport AT dpchandrasiri coamoxiclavinducedimmunehaemolyticanaemiaacasereport AT pranasinghe coamoxiclavinducedimmunehaemolyticanaemiaacasereport AT vratnamalala coamoxiclavinducedimmunehaemolyticanaemiaacasereport AT ahnfernando coamoxiclavinducedimmunehaemolyticanaemiaacasereport |