Impaired network organization in mild age‐related hearing loss
Abstract Age‐related hearing loss (ARHL) is considered one of the most common neurodegenerative disorders in the elderly; however, how it contributes to cognitive decline is poorly understood. With resting‐state functional magnetic resonance imaging from 66 individuals with ARHL and 54 healthy contr...
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| Format: | Article |
| Language: | English |
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Wiley
2025-01-01
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| Series: | MedComm |
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| Online Access: | https://doi.org/10.1002/mco2.70002 |
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| author | Zhaopeng Tong Chunhua Xing Xiaomin Xu Jin‐Jing Xu Yuanqing Wu Richard Salvi Xindao Yin Fei Zhao Yu‐Chen Chen Yuexin Cai |
| author_facet | Zhaopeng Tong Chunhua Xing Xiaomin Xu Jin‐Jing Xu Yuanqing Wu Richard Salvi Xindao Yin Fei Zhao Yu‐Chen Chen Yuexin Cai |
| author_sort | Zhaopeng Tong |
| collection | DOAJ |
| description | Abstract Age‐related hearing loss (ARHL) is considered one of the most common neurodegenerative disorders in the elderly; however, how it contributes to cognitive decline is poorly understood. With resting‐state functional magnetic resonance imaging from 66 individuals with ARHL and 54 healthy controls, group spatial independent component analyses, sliding window analyses, graph‐theory methods, multilayer networks, and correlation analyses were used to identify ARHL‐induced disturbances in static and dynamic functional network connectivity (sFNC/dFNC), alterations in global network switching and their links to cognitive performances. ARHL was associated with decreased sFNC/dFNC within the default mode network (DMN) and increased sFNC/dFNC between the DMN and central executive, salience (SN), and visual networks. The variability in dFNC between the DMN and auditory network (AUN) and between the SN and AUN was decreased in ARHL. The individuals with ARHL had lower network switching rates than controls among global network nodes, especially in the DMN. Some disturbances within DMN were associated with disrupted executive and memory performance. The prolonged loss of sensory information associated with ARHL‐induced compensatory within‐network segregations and between‐network integrations in the DMN might reduce network information processing and accelerate brain aging and cognitive decline. |
| format | Article |
| id | doaj-art-46ea67813dc54093b1d26add24c4e3c5 |
| institution | Kabale University |
| issn | 2688-2663 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | MedComm |
| spelling | doaj-art-46ea67813dc54093b1d26add24c4e3c52025-01-20T01:45:44ZengWileyMedComm2688-26632025-01-0161n/an/a10.1002/mco2.70002Impaired network organization in mild age‐related hearing lossZhaopeng Tong0Chunhua Xing1Xiaomin Xu2Jin‐Jing Xu3Yuanqing Wu4Richard Salvi5Xindao Yin6Fei Zhao7Yu‐Chen Chen8Yuexin Cai9Department of Otolaryngology Sun Yat‐sen Memorial Hospital Sun Yat‐sen University Guangzhou ChinaDepartment of Radiology Nanjing First Hospital Nanjing Medical University Nanjing ChinaDepartment of Radiology Nanjing First Hospital Nanjing Medical University Nanjing ChinaDepartment of Otolaryngology Nanjing First Hospital Nanjing Medical University Nanjing ChinaDepartment of Otolaryngology Nanjing First Hospital Nanjing Medical University Nanjing ChinaCenter for Hearing and Deafness State University of New York at Buffalo Buffalo New York USADepartment of Radiology Nanjing First Hospital Nanjing Medical University Nanjing ChinaDepartment of Speech and Language Therapy and Hearing Science Cardiff Metropolitan University Cardiff UKDepartment of Radiology Nanjing First Hospital Nanjing Medical University Nanjing ChinaDepartment of Otolaryngology Sun Yat‐sen Memorial Hospital Sun Yat‐sen University Guangzhou ChinaAbstract Age‐related hearing loss (ARHL) is considered one of the most common neurodegenerative disorders in the elderly; however, how it contributes to cognitive decline is poorly understood. With resting‐state functional magnetic resonance imaging from 66 individuals with ARHL and 54 healthy controls, group spatial independent component analyses, sliding window analyses, graph‐theory methods, multilayer networks, and correlation analyses were used to identify ARHL‐induced disturbances in static and dynamic functional network connectivity (sFNC/dFNC), alterations in global network switching and their links to cognitive performances. ARHL was associated with decreased sFNC/dFNC within the default mode network (DMN) and increased sFNC/dFNC between the DMN and central executive, salience (SN), and visual networks. The variability in dFNC between the DMN and auditory network (AUN) and between the SN and AUN was decreased in ARHL. The individuals with ARHL had lower network switching rates than controls among global network nodes, especially in the DMN. Some disturbances within DMN were associated with disrupted executive and memory performance. The prolonged loss of sensory information associated with ARHL‐induced compensatory within‐network segregations and between‐network integrations in the DMN might reduce network information processing and accelerate brain aging and cognitive decline.https://doi.org/10.1002/mco2.70002cognitionnetwork reorganizationneuroimagingpresbycusis |
| spellingShingle | Zhaopeng Tong Chunhua Xing Xiaomin Xu Jin‐Jing Xu Yuanqing Wu Richard Salvi Xindao Yin Fei Zhao Yu‐Chen Chen Yuexin Cai Impaired network organization in mild age‐related hearing loss MedComm cognition network reorganization neuroimaging presbycusis |
| title | Impaired network organization in mild age‐related hearing loss |
| title_full | Impaired network organization in mild age‐related hearing loss |
| title_fullStr | Impaired network organization in mild age‐related hearing loss |
| title_full_unstemmed | Impaired network organization in mild age‐related hearing loss |
| title_short | Impaired network organization in mild age‐related hearing loss |
| title_sort | impaired network organization in mild age related hearing loss |
| topic | cognition network reorganization neuroimaging presbycusis |
| url | https://doi.org/10.1002/mco2.70002 |
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