Value of Systematic and MRI‐Ultrasound Fusion Prostate Biopsy in Different Prostate Specific Antigen (PSA) Levels
ABSTRACT Background Current approach to clinically suspicious biopsy‐naïve men consists performing prostate MRI, followed by combined systematic (TRUS‐Bx) and MRI‐Ultrasound fusion biopsy (MRI‐TBx) in those with PIRADS score ≥ 3. Researchers have attempted to determine who benefits from each biopsy...
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| Format: | Article |
| Language: | English |
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Wiley
2025-01-01
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| Series: | Cancer Reports |
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| Online Access: | https://doi.org/10.1002/cnr2.70099 |
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| author | Solmaz Ohadian Moghadam Mohammad Haddadi Erfan Amini Seyed Ali Momeni Masoud Bitaraf Mohammad Reza Nowroozi |
| author_facet | Solmaz Ohadian Moghadam Mohammad Haddadi Erfan Amini Seyed Ali Momeni Masoud Bitaraf Mohammad Reza Nowroozi |
| author_sort | Solmaz Ohadian Moghadam |
| collection | DOAJ |
| description | ABSTRACT Background Current approach to clinically suspicious biopsy‐naïve men consists performing prostate MRI, followed by combined systematic (TRUS‐Bx) and MRI‐Ultrasound fusion biopsy (MRI‐TBx) in those with PIRADS score ≥ 3. Researchers have attempted to determine who benefits from each biopsy method, but the results do not support the safe use of one method alone. This study aims to determine the optimal approach in biopsy‐naïve men, according to their PSA levels. Methods and Results A retrospective chart review of clinically suspicious biopsy‐naïve men who underwent both TRUS‐Bx and MRI‐TBx was done. Prostate specific antigen (PSA) levels were compared between patients only positive for MRI‐TBx and those with positive TRUS‐Bx. Further, cancer cases were divided to < 10 and ≥ 10 PSA groups and the pathology results, obtained by each method, were compared. Out of 195 men, 36 were diagnosed with prostate cancer (PCa). PCa was diagnosed by both MRI‐TBx and TRUS‐Bx in 26 men, half of whom had PSA > 10 ng/mL. At PSA ≤ 10 ng/mL, PCa would have been missed in 4 men (11.1%) had MRI‐TBx not been done, and in 6 men (16.6%) had TRUS‐Bx not been done. Conclusion Despite attempts to perform only one biopsy method in men with clinical suspicion of prostate cancer, we propose that at least in men with PSA ≤ 10 ng/mL, both systematic and MRI‐targeted biopsies be performed. |
| format | Article |
| id | doaj-art-4699519c46bb4935b5dcf015c8451cfb |
| institution | Kabale University |
| issn | 2573-8348 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Reports |
| spelling | doaj-art-4699519c46bb4935b5dcf015c8451cfb2025-01-30T15:46:35ZengWileyCancer Reports2573-83482025-01-0181n/an/a10.1002/cnr2.70099Value of Systematic and MRI‐Ultrasound Fusion Prostate Biopsy in Different Prostate Specific Antigen (PSA) LevelsSolmaz Ohadian Moghadam0Mohammad Haddadi1Erfan Amini2Seyed Ali Momeni3Masoud Bitaraf4Mohammad Reza Nowroozi5Uro‐Oncology Research Center Tehran University of Medical Sciences Tehran IranUro‐Oncology Research Center Tehran University of Medical Sciences Tehran IranUro‐Oncology Research Center Tehran University of Medical Sciences Tehran IranUro‐Oncology Research Center Tehran University of Medical Sciences Tehran IranUro‐Oncology Research Center Tehran University of Medical Sciences Tehran IranUro‐Oncology Research Center Tehran University of Medical Sciences Tehran IranABSTRACT Background Current approach to clinically suspicious biopsy‐naïve men consists performing prostate MRI, followed by combined systematic (TRUS‐Bx) and MRI‐Ultrasound fusion biopsy (MRI‐TBx) in those with PIRADS score ≥ 3. Researchers have attempted to determine who benefits from each biopsy method, but the results do not support the safe use of one method alone. This study aims to determine the optimal approach in biopsy‐naïve men, according to their PSA levels. Methods and Results A retrospective chart review of clinically suspicious biopsy‐naïve men who underwent both TRUS‐Bx and MRI‐TBx was done. Prostate specific antigen (PSA) levels were compared between patients only positive for MRI‐TBx and those with positive TRUS‐Bx. Further, cancer cases were divided to < 10 and ≥ 10 PSA groups and the pathology results, obtained by each method, were compared. Out of 195 men, 36 were diagnosed with prostate cancer (PCa). PCa was diagnosed by both MRI‐TBx and TRUS‐Bx in 26 men, half of whom had PSA > 10 ng/mL. At PSA ≤ 10 ng/mL, PCa would have been missed in 4 men (11.1%) had MRI‐TBx not been done, and in 6 men (16.6%) had TRUS‐Bx not been done. Conclusion Despite attempts to perform only one biopsy method in men with clinical suspicion of prostate cancer, we propose that at least in men with PSA ≤ 10 ng/mL, both systematic and MRI‐targeted biopsies be performed.https://doi.org/10.1002/cnr2.70099fusion biopsyMRI‐targeted biopsyprostate cancerprostate specific antigenPSAtransrectal biopsy |
| spellingShingle | Solmaz Ohadian Moghadam Mohammad Haddadi Erfan Amini Seyed Ali Momeni Masoud Bitaraf Mohammad Reza Nowroozi Value of Systematic and MRI‐Ultrasound Fusion Prostate Biopsy in Different Prostate Specific Antigen (PSA) Levels Cancer Reports fusion biopsy MRI‐targeted biopsy prostate cancer prostate specific antigen PSA transrectal biopsy |
| title | Value of Systematic and MRI‐Ultrasound Fusion Prostate Biopsy in Different Prostate Specific Antigen (PSA) Levels |
| title_full | Value of Systematic and MRI‐Ultrasound Fusion Prostate Biopsy in Different Prostate Specific Antigen (PSA) Levels |
| title_fullStr | Value of Systematic and MRI‐Ultrasound Fusion Prostate Biopsy in Different Prostate Specific Antigen (PSA) Levels |
| title_full_unstemmed | Value of Systematic and MRI‐Ultrasound Fusion Prostate Biopsy in Different Prostate Specific Antigen (PSA) Levels |
| title_short | Value of Systematic and MRI‐Ultrasound Fusion Prostate Biopsy in Different Prostate Specific Antigen (PSA) Levels |
| title_sort | value of systematic and mri ultrasound fusion prostate biopsy in different prostate specific antigen psa levels |
| topic | fusion biopsy MRI‐targeted biopsy prostate cancer prostate specific antigen PSA transrectal biopsy |
| url | https://doi.org/10.1002/cnr2.70099 |
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