Efficacy of dietary modifications and mucosal protectors in the treatment of laryngopharyngeal reflux: a multicenter study
BackgroundLaryngopharyngeal reflux (LPR) is defined as an extraesophageal reflux of gastroduodenal contents to the laryngopharynx, affecting the upper aerodigestive tract. There is currently no standardized treatment protocol for LPR. The use of proton pump inhibitors (PPIs) is widely established in...
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Frontiers Media S.A.
2025-01-01
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2025.1488323/full |
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| author | Matteo Gelardi Rossana Giancaspro Christian Fiorentino Stefano Patruno Jacopo Marroni Alessandro D’Avino Letizia Neri Michele Cassano Giampiero Neri |
| author_facet | Matteo Gelardi Rossana Giancaspro Christian Fiorentino Stefano Patruno Jacopo Marroni Alessandro D’Avino Letizia Neri Michele Cassano Giampiero Neri |
| author_sort | Matteo Gelardi |
| collection | DOAJ |
| description | BackgroundLaryngopharyngeal reflux (LPR) is defined as an extraesophageal reflux of gastroduodenal contents to the laryngopharynx, affecting the upper aerodigestive tract. There is currently no standardized treatment protocol for LPR. The use of proton pump inhibitors (PPIs) is widely established in common practice and derives from the standard approach of using PPIs to treat patients with gastroesophageal reflux disease (GERD). However, as PPIs may not be effective on all types of reflux, the aim of our study was to evaluate the effectiveness of dietary changes and mucosal protectants, alone or in combination, in LPR treatment.MethodsThis multicenter randomized controlled trial included 48 patients divided into three groups: dietary modifications only, mucosal protectors only, and a combination of both. The patients’ responses were assessed over 1 month using the Reflux Symptom Index (RSI) and Reflux Finding Score (RFS), along with measurements of salivary and nasal pepsin concentration and rhinomanometry.ResultsSignificant improvements were observed in RSI and RFS scores across all groups. The group receiving combined dietary modifications and mucosal protectors showed the most substantial benefits. Additionally, a notable reduction in salivary and nasal pepsin concentrations and nasal resistances was observed, particularly in patients combining dietary modifications and mucosal protectors.ConclusionThe study showed that combined dietary modifications and mucosal protects strategies effectively manage LPR symptoms, offering a potential therapeutic approach. |
| format | Article |
| id | doaj-art-4693aa172a2d453cb1adf9f6b009f7dd |
| institution | Kabale University |
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| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Medicine |
| spelling | doaj-art-4693aa172a2d453cb1adf9f6b009f7dd2025-01-27T06:40:53ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-01-011210.3389/fmed.2025.14883231488323Efficacy of dietary modifications and mucosal protectors in the treatment of laryngopharyngeal reflux: a multicenter studyMatteo Gelardi0Rossana Giancaspro1Christian Fiorentino2Stefano Patruno3Jacopo Marroni4Alessandro D’Avino5Letizia Neri6Michele Cassano7Giampiero Neri8Unit of Otolaryngology, Department of Clinical and Experimental Medicine, University of Foggia, Foggia, ItalyUnit of Otolaryngology, Department of Clinical and Experimental Medicine, University of Foggia, Foggia, ItalyUnit of Otolaryngology, Department of Clinical and Experimental Medicine, University of Foggia, Foggia, ItalyUnit of Otolaryngology, Department of Clinical and Experimental Medicine, University of Foggia, Foggia, ItalyNeurosciences Imaging and Clinical Sciences Department, University of Chieti-Pescara, Chieti, ItalyDepartment of Medical Sciences, IDI-IRCCS, Rome, ItalyDepartment of Otolayngology, University of Insubria, Varese, VA, ItalyUnit of Otolaryngology, Department of Clinical and Experimental Medicine, University of Foggia, Foggia, ItalyNeurosciences Imaging and Clinical Sciences Department, University of Chieti-Pescara, Chieti, ItalyBackgroundLaryngopharyngeal reflux (LPR) is defined as an extraesophageal reflux of gastroduodenal contents to the laryngopharynx, affecting the upper aerodigestive tract. There is currently no standardized treatment protocol for LPR. The use of proton pump inhibitors (PPIs) is widely established in common practice and derives from the standard approach of using PPIs to treat patients with gastroesophageal reflux disease (GERD). However, as PPIs may not be effective on all types of reflux, the aim of our study was to evaluate the effectiveness of dietary changes and mucosal protectants, alone or in combination, in LPR treatment.MethodsThis multicenter randomized controlled trial included 48 patients divided into three groups: dietary modifications only, mucosal protectors only, and a combination of both. The patients’ responses were assessed over 1 month using the Reflux Symptom Index (RSI) and Reflux Finding Score (RFS), along with measurements of salivary and nasal pepsin concentration and rhinomanometry.ResultsSignificant improvements were observed in RSI and RFS scores across all groups. The group receiving combined dietary modifications and mucosal protectors showed the most substantial benefits. Additionally, a notable reduction in salivary and nasal pepsin concentrations and nasal resistances was observed, particularly in patients combining dietary modifications and mucosal protectors.ConclusionThe study showed that combined dietary modifications and mucosal protects strategies effectively manage LPR symptoms, offering a potential therapeutic approach.https://www.frontiersin.org/articles/10.3389/fmed.2025.1488323/fulllaryngopharyngeal refluxdietary modificationsmucosal protectorspepsinpep test |
| spellingShingle | Matteo Gelardi Rossana Giancaspro Christian Fiorentino Stefano Patruno Jacopo Marroni Alessandro D’Avino Letizia Neri Michele Cassano Giampiero Neri Efficacy of dietary modifications and mucosal protectors in the treatment of laryngopharyngeal reflux: a multicenter study Frontiers in Medicine laryngopharyngeal reflux dietary modifications mucosal protectors pepsin pep test |
| title | Efficacy of dietary modifications and mucosal protectors in the treatment of laryngopharyngeal reflux: a multicenter study |
| title_full | Efficacy of dietary modifications and mucosal protectors in the treatment of laryngopharyngeal reflux: a multicenter study |
| title_fullStr | Efficacy of dietary modifications and mucosal protectors in the treatment of laryngopharyngeal reflux: a multicenter study |
| title_full_unstemmed | Efficacy of dietary modifications and mucosal protectors in the treatment of laryngopharyngeal reflux: a multicenter study |
| title_short | Efficacy of dietary modifications and mucosal protectors in the treatment of laryngopharyngeal reflux: a multicenter study |
| title_sort | efficacy of dietary modifications and mucosal protectors in the treatment of laryngopharyngeal reflux a multicenter study |
| topic | laryngopharyngeal reflux dietary modifications mucosal protectors pepsin pep test |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2025.1488323/full |
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