Argonaute2 modulates megakaryocyte development and sex-specific control of platelet protein expression and reactivity

Argonaute2 modulates megakaryocyte development and sex-specific control of platelet protein expression and reactivity

Abstract Platelets are enriched in miRNAs and harbor Ago2 as the principal RNA silencing Argonaute. However, roles in thrombopoiesis and platelet function remain poorly understood. We generated megakaryocyte/platelet-specific Ago2-deleted (Ago2 KO) mice and assessed proteomic and functional effects....

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Bibliographic Details
Main Authors: Sophia Lazar, Jeremy G.T. Wurtzel, Shayan Askari, Matthew Cooper, Xuefei Zhao, Peisong Ma, Lawrence E. Goldfinger
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
miRNA
Argonaute
RISC
Proteomics
Hemostasis
Megakaryocyte
Online Access:https://doi.org/10.1038/s41598-025-88106-0
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