Characterization, Diagnosis, and Multidisciplinary Management of Late-Onset Wilms Tumor/Nephroblastoma: Case Report and Literature Review
Introduction: Wilms tumor, or nephroblastoma, is a renal neoplasm that originates from alterations in renal embryogenesis. It predominantly affects pediatric patients (only 3% occur in adults) and has a significant genetic component, being associated with syndromes such as Denys-Drash, Perlman, and...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | Spanish |
| Published: |
Universidad de Antioquia
2025-07-01
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| Series: | Iatreia |
| Subjects: | |
| Online Access: | https://revistas.udea.edu.co/index.php/iatreia/article/view/352625 |
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| Summary: | Introduction: Wilms tumor, or nephroblastoma, is a renal neoplasm that originates from alterations in renal embryogenesis. It predominantly affects pediatric patients (only 3% occur in adults) and has a significant genetic component, being associated with syndromes such as Denys-Drash, Perlman, and Beckwith-Wiedemann. The initial clinical presentation typically includes an abdominal mass (usually detected at advanced stages) with intermittent hematuria, and may involve adjacent organs.
Treatment: Management should be multimodal and multidisciplinary, with surgery, chemotherapy, and radiotherapy as the mainstays, their appropriateness and sequence determined according to staging protocols from the Children’s Oncology Group (COG) and the International Society of Pediatric Oncology (SIOP).
Case report: We present a case of Wilms tumor in an adult patient, describing clinical and paraclinical features, surgical approach, pathological studies performed, and selected chemotherapy and radiotherapy regimens. |
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| ISSN: | 0121-0793 2011-7965 |