TransTACs: Transforming antibodies into targeted protein degraders

TransTACs: Transforming antibodies into targeted protein degraders

Saved in:

Bibliographic Details
Main Authors:	Yu Guo, Jinxin Che, Xiaowu Dong
Format:	Article
Language:	English
Published:	Elsevier 2025-02-01
Series:	Acta Pharmaceutica Sinica B
Subjects:	Targeted protein degradation Membrane and extracellular proteins Transferrin receptor-targeting chimeras Protein homeostasis regulation Tumor therapy
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211383525000061
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Targeted degradation of extracellular proteins: state of the art and diversity of degrader designs
by: M. A. A. Mamun, et al.
Published: (2025-05-01)

Cancer Specific CAIX‐Targeting Supramolecular Lysosome‐Targeting Chimeras (Supra‐LYTAC) for Targeted Protein Degradation
by: Dohyun Kim, et al.
Published: (2025-07-01)

Orthogonal validation of PROTAC mediated degradation of the integral membrane proteins EGFR and c-MET
by: Camilla Ruffilli, et al.
Published: (2025-01-01)

GPC3-mediated lysosome-targeting chimeras (GLTACs) for targeted degradation of membrane proteins
by: Yuxin Fang, et al.
Published: (2025-04-01)

Influenza A virus hemagglutinin: from classical fusion inhibitors to proteolysis targeting chimera-based strategies in antiviral drug discovery
by: Francisco Javier Hermoso-Pinilla, et al.
Published: (2024-02-01)

Towards the Rational Design of Monovalent Degraders: Lessons Learnt from Cyclin K Degraders
by: Katie L. Thomas, et al.
Published: (2025-03-01)

TransTACs: novel heterobispecific antibodies for targeted protein degradation in cancer therapy
by: Wolfgang Walther, et al.
Published: (2024-11-01)

Targeted protein degradation with small molecules for cancer immunotherapy
by: Zichao Yang, et al.
Published: (2025-08-01)

TRIM21-based degradation strategy for multimeric proteins
by: Wei Wang, et al.
Published: (2025-05-01)

DNA Tweezers with Replaceable Clamps for the Targeted Degradation of Cell Membrane Proteins
by: Yang Sun, et al.
Published: (2025-06-01)

Oligonucleotide-based PROTACs to Degrade RNA- and DNA-Binding Proteins
by: Céline N. Weller, et al.
Published: (2025-03-01)

Editorial: The potential of transferrin as a drug target and drug delivery system
by: Patricia Carrilho, et al.
Published: (2025-03-01)

Design and development of PROTACs: A new paradigm in anticancer drug discovery
by: Vishal Mathur, et al.
Published: (2025-09-01)

Single domain antibody-scFv conjugate targeting amyloid β and TfR penetrates the blood–brain barrier and interacts with amyloid β
by: Rebecca Faresjö, et al.
Published: (2024-12-01)

Targeted degradation of sICOSL reverses cytotoxic T cells dysfunction
by: Zhenghao Wu, et al.
Published: (2025-07-01)

Breakthroughs in treatment for hematological malignancies: latest updates on molecular glue, PROTACs and RNA degraders from ASH 2024
by: Na Li, et al.
Published: (2025-03-01)

Targeted protein editing technique in living mammalian cells by peptide-fused PNGase
by: Min Wu, et al.
Published: (2024-11-01)

Discovery of Potent Degraders of the Dengue Virus Envelope Protein
by: Zhengnian Li, et al.
Published: (2024-10-01)

HaloPROTAC3 does not trigger the degradation of the halotagged parasitophorous vacuole membrane protein UIS4 during Plasmodium liver stage development
by: Melanie Lam, et al.
Published: (2025-05-01)

Research and development prospects of TRIM65
by: Nian-Hua Deng, et al.
Published: (2025-08-01)

PROTAC-Based Antivirals for Respiratory Viruses: A Novel Approach for Targeted Therapy and Vaccine Development
by: Amith Anugu, et al.
Published: (2025-07-01)

Antibody-mediated degradation of 4R-tau restores mitochondrial membrane polarization in human induced pluripotent stem cell-derived neurons with the MAPT 10+16 mutation
by: Dale O. Starkie, et al.
Published: (2024-12-01)

Recent Advances in Peptide Drug Discovery: Novel Strategies and Targeted Protein Degradation
by: Katarina Vrbnjak, et al.
Published: (2024-11-01)

Molecular Design of Novel Protein-Degrading Therapeutics Agents Currently in Clinical Trial
by: Ela Kacin, et al.
Published: (2025-06-01)

Innovative discovery and mechanistic validation of HyT-PD ligands for selective CDK9-targeted protein degradation
by: Yizhan Zhai, et al.
Published: (2025-05-01)

Sequence signatures and mRNA concentration can explain two‐thirds of protein abundance variation in a human cell line
by: Christine Vogel, et al.
Published: (2010-08-01)

PROTAC-induced protein structural dynamics in targeted protein degradation
by: Kingsley Y Wu, et al.
Published: (2025-02-01)

Reversing TGF-β1-induced fibrotic phenotype in human lung fibroblasts using a PROTAC tool derived from an indoline-based HDAC6 inhibitor
by: Ilaria Cursaro, et al.
Published: (2025-08-01)

Development and evaluation of curcumin nano-niosomes for glioma-targeted therapy
by: Hao Qian, et al.
Published: (2025-03-01)

Pegylated gold nanoparticles interact with lipid bilayer and human serum albumin and transferrin
by: Elżbieta Okła, et al.
Published: (2024-10-01)

Micronutrient Biomarkers and Their Association with Malaria Infection in Children in Buea Health District, Cameroon
by: Jerome Nyhalah Dinga, et al.
Published: (2024-12-01)

Savremena saznanja o molekulskim mehanizmima regulacije homeostaze gvožđa
by: Popović Petar, et al.
Published: (2002-01-01)

Editorial: Protein regulation by lipids
by: Mikhail V. Bogdanov, et al.
Published: (2025-08-01)

Machine learning proteochemometric models for Cereblon glue activity predictions
by: Francis J. Prael, III, et al.
Published: (2024-12-01)

Identification of Population-Specific Novel Protein Biomarkers and Possible Therapeutic Targets in Gliomas by Proteomics Approach
by: S. Devanand Senthil Kumar, et al.
Published: (2025-03-01)

The ubiquitin-proteasome system in circadian regulation
by: Kara M. Costanzo, et al.
Published: (2025-08-01)

FDA-approved kinase inhibitors in PROTAC design, development and synthesis
by: Kacper Kossakowski, et al.
Published: (2025-12-01)

SID-2 is a conserved extracellular vesicle protein that is not associated with environmental RNAi in parasitic nematodes
by: Frances Blow, et al.
Published: (2024-11-01)

Yacton and mexicor influence on prooxidant-antioxidant homeostasis and protein synthesis in the myocardium of rats in conditions of doxorubicin cardiomyopathy
by: E. A. Raketskaya, et al.
Published: (2015-04-01)

SymRK Regulates G-Protein Signaling During Nodulation in Soybean (Glycine max) by Modifying RGS Phosphorylation and Activity
by: Swarup Roy Choudhury, et al.
Published: (2024-11-01)