Intracytoplasmic Crystalline Inclusions in the Hepatocytes of an Antelope
This case report describes intracytoplasmic crystalline inclusions in the hepatocytes of a 13-year-old female Thomson's gazelle. Histologically, multifocal to coalescing areas of many hepatocytes contained large cytoplasmic vacuoles filled with pale eosinophilic homogeneous material and rare fi...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Veterinary Medicine International |
| Online Access: | http://dx.doi.org/10.4061/2010/373698 |
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| _version_ | 1832560729559924736 |
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| author | Sanjeev Gumber Eric Lombardini Bruce Williams Nobuko Wakamatsu |
| author_facet | Sanjeev Gumber Eric Lombardini Bruce Williams Nobuko Wakamatsu |
| author_sort | Sanjeev Gumber |
| collection | DOAJ |
| description | This case report describes intracytoplasmic crystalline inclusions in the hepatocytes of a 13-year-old female Thomson's gazelle. Histologically, multifocal to coalescing areas of many hepatocytes contained large cytoplasmic vacuoles filled with pale eosinophilic homogeneous material and rare fine basophilic granules. Von Kossa staining showed the presence of calcium within cytoplasm, mainly in the inclusions, of hepatocytes. Transmission electron microscopy, scanning electron microscopy, energy dispersive X-rays analyses, and infrared spectroscopy on the liver showed the hepatocellular material consistent with protein and carbohydrate with secondary accumulation of calcium and phosphorus. It was concluded that crystalline inclusions may have been derived due to failure of normal physiological hepatocellular clearance associated with a severe chronic disease. To the authors' knowledge this is the first reported case of hepatocellular crystalline inclusions in an antelope. |
| format | Article |
| id | doaj-art-467d678da121403baf5a358d10edd676 |
| institution | Kabale University |
| issn | 2042-0048 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Veterinary Medicine International |
| spelling | doaj-art-467d678da121403baf5a358d10edd6762025-02-03T01:26:46ZengWileyVeterinary Medicine International2042-00482010-01-01201010.4061/2010/373698373698Intracytoplasmic Crystalline Inclusions in the Hepatocytes of an AntelopeSanjeev Gumber0Eric Lombardini1Bruce Williams2Nobuko Wakamatsu3Department of Pathobiological Sciences, School of Veterinary Medicine, Louisiana State University, Skip Bertman Drive, Baton Rouge, LA 70803, USAArmed Forces Institute of Pathology, Department of Defense, Washington, DC 20306-6000, USAArmed Forces Institute of Pathology, Department of Defense, Washington, DC 20306-6000, USADepartment of Pathobiological Sciences, School of Veterinary Medicine, Louisiana State University, Skip Bertman Drive, Baton Rouge, LA 70803, USAThis case report describes intracytoplasmic crystalline inclusions in the hepatocytes of a 13-year-old female Thomson's gazelle. Histologically, multifocal to coalescing areas of many hepatocytes contained large cytoplasmic vacuoles filled with pale eosinophilic homogeneous material and rare fine basophilic granules. Von Kossa staining showed the presence of calcium within cytoplasm, mainly in the inclusions, of hepatocytes. Transmission electron microscopy, scanning electron microscopy, energy dispersive X-rays analyses, and infrared spectroscopy on the liver showed the hepatocellular material consistent with protein and carbohydrate with secondary accumulation of calcium and phosphorus. It was concluded that crystalline inclusions may have been derived due to failure of normal physiological hepatocellular clearance associated with a severe chronic disease. To the authors' knowledge this is the first reported case of hepatocellular crystalline inclusions in an antelope.http://dx.doi.org/10.4061/2010/373698 |
| spellingShingle | Sanjeev Gumber Eric Lombardini Bruce Williams Nobuko Wakamatsu Intracytoplasmic Crystalline Inclusions in the Hepatocytes of an Antelope Veterinary Medicine International |
| title | Intracytoplasmic Crystalline Inclusions in the Hepatocytes of an Antelope |
| title_full | Intracytoplasmic Crystalline Inclusions in the Hepatocytes of an Antelope |
| title_fullStr | Intracytoplasmic Crystalline Inclusions in the Hepatocytes of an Antelope |
| title_full_unstemmed | Intracytoplasmic Crystalline Inclusions in the Hepatocytes of an Antelope |
| title_short | Intracytoplasmic Crystalline Inclusions in the Hepatocytes of an Antelope |
| title_sort | intracytoplasmic crystalline inclusions in the hepatocytes of an antelope |
| url | http://dx.doi.org/10.4061/2010/373698 |
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