Phylogeography of the woolly mammoth (<i>Mammuthus primigenius</i>) in the Minusinsk Depression of southern Siberia in the Late Pleistocene
To date, a number of studies have been published on the phylogenetics of woolly mammoths (Mammuthus primigenius), ranging from analyses of parts of the mitochondrial genome to studies of complete nuclear genomes. However, until recently nothing was known about the genetic diversity of woolly mammoth...
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Siberian Branch of the Russian Academy of Sciences, Federal Research Center Institute of Cytology and Genetics, The Vavilov Society of Geneticists and Breeders
2024-09-01
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| Series: | Вавиловский журнал генетики и селекции |
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| Online Access: | https://vavilov.elpub.ru/jour/article/view/4239 |
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| author | S. A. Modina M. A. Kusliy D. G. Malikov A. S. Molodtseva |
| author_facet | S. A. Modina M. A. Kusliy D. G. Malikov A. S. Molodtseva |
| author_sort | S. A. Modina |
| collection | DOAJ |
| description | To date, a number of studies have been published on the phylogenetics of woolly mammoths (Mammuthus primigenius), ranging from analyses of parts of the mitochondrial genome to studies of complete nuclear genomes. However, until recently nothing was known about the genetic diversity of woolly mammoths in southern Siberia, in the Minusinsk Depression in particular. Within the framework of this effort, libraries for high-throughput sequencing of seven bone samples of woolly mammoths were obtained, two-round enrichment using biotinylated probes of modern mtDNA of Elephas maximus immobilised on magnetic microspheres and sequencing with subsequent bioinformatic analysis were carried out. Phylogenetic reconstructions showed the presence of all studied mammoths in clade I, which expanded its range. The assignment of mammoth mitotypes in the Minusinsk Depression to different clusters within clade I may indicate a sufficiently high diversity of their gene pool. Phylogeographic reconstructions revealed a genetic proximity of mitochondrial lineages of Late Pleistocene mammoths of the Minusinsk Depression and other regions of eastern Siberia and estimated their divergence time in the range of 100–150 thousand years ago, which indicates active migrations of woolly mammoths over vast territories of eastern Siberia in the late Middle Pleistoceneearly Late Pleistocene. |
| format | Article |
| id | doaj-art-466c9e43d91f4eaaad2717284ddad28d |
| institution | Kabale University |
| issn | 2500-3259 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | Siberian Branch of the Russian Academy of Sciences, Federal Research Center Institute of Cytology and Genetics, The Vavilov Society of Geneticists and Breeders |
| record_format | Article |
| series | Вавиловский журнал генетики и селекции |
| spelling | doaj-art-466c9e43d91f4eaaad2717284ddad28d2025-02-01T09:58:13ZengSiberian Branch of the Russian Academy of Sciences, Federal Research Center Institute of Cytology and Genetics, The Vavilov Society of Geneticists and BreedersВавиловский журнал генетики и селекции2500-32592024-09-0128557157710.18699/vjgb-24-631492Phylogeography of the woolly mammoth (<i>Mammuthus primigenius</i>) in the Minusinsk Depression of southern Siberia in the Late PleistoceneS. A. Modina0M. A. Kusliy1D. G. Malikov2A. S. Molodtseva3Institute of Molecular and Cellular Biology of the Siberian Branch of the Russian Academy of Sciences; Novosibirsk State UniversityInstitute of Molecular and Cellular Biology of the Siberian Branch of the Russian Academy of SciencesInstitute of Molecular and Cellular Biology of the Siberian Branch of the Russian Academy of Sciences; V.S. Sobolev Institute of Geology and Mineralogy of the Siberian Branch of the Russian Academy of SciencesInstitute of Molecular and Cellular Biology of the Siberian Branch of the Russian Academy of Sciences; Institute of Archaeology and Ethnography, Siberian Branch of the Russian Academy of SciencesTo date, a number of studies have been published on the phylogenetics of woolly mammoths (Mammuthus primigenius), ranging from analyses of parts of the mitochondrial genome to studies of complete nuclear genomes. However, until recently nothing was known about the genetic diversity of woolly mammoths in southern Siberia, in the Minusinsk Depression in particular. Within the framework of this effort, libraries for high-throughput sequencing of seven bone samples of woolly mammoths were obtained, two-round enrichment using biotinylated probes of modern mtDNA of Elephas maximus immobilised on magnetic microspheres and sequencing with subsequent bioinformatic analysis were carried out. Phylogenetic reconstructions showed the presence of all studied mammoths in clade I, which expanded its range. The assignment of mammoth mitotypes in the Minusinsk Depression to different clusters within clade I may indicate a sufficiently high diversity of their gene pool. Phylogeographic reconstructions revealed a genetic proximity of mitochondrial lineages of Late Pleistocene mammoths of the Minusinsk Depression and other regions of eastern Siberia and estimated their divergence time in the range of 100–150 thousand years ago, which indicates active migrations of woolly mammoths over vast territories of eastern Siberia in the late Middle Pleistoceneearly Late Pleistocene.https://vavilov.elpub.ru/jour/article/view/4239ancient dnawoolly mammothphylogeographymitochondrial genomesouthern siberia |
| spellingShingle | S. A. Modina M. A. Kusliy D. G. Malikov A. S. Molodtseva Phylogeography of the woolly mammoth (<i>Mammuthus primigenius</i>) in the Minusinsk Depression of southern Siberia in the Late Pleistocene Вавиловский журнал генетики и селекции ancient dna woolly mammoth phylogeography mitochondrial genome southern siberia |
| title | Phylogeography of the woolly mammoth (<i>Mammuthus primigenius</i>) in the Minusinsk Depression of southern Siberia in the Late Pleistocene |
| title_full | Phylogeography of the woolly mammoth (<i>Mammuthus primigenius</i>) in the Minusinsk Depression of southern Siberia in the Late Pleistocene |
| title_fullStr | Phylogeography of the woolly mammoth (<i>Mammuthus primigenius</i>) in the Minusinsk Depression of southern Siberia in the Late Pleistocene |
| title_full_unstemmed | Phylogeography of the woolly mammoth (<i>Mammuthus primigenius</i>) in the Minusinsk Depression of southern Siberia in the Late Pleistocene |
| title_short | Phylogeography of the woolly mammoth (<i>Mammuthus primigenius</i>) in the Minusinsk Depression of southern Siberia in the Late Pleistocene |
| title_sort | phylogeography of the woolly mammoth i mammuthus primigenius i in the minusinsk depression of southern siberia in the late pleistocene |
| topic | ancient dna woolly mammoth phylogeography mitochondrial genome southern siberia |
| url | https://vavilov.elpub.ru/jour/article/view/4239 |
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