Seropositivity of Dengue Antibodies during Pregnancy
Purpose. Malaysia a dengue endemic country with dengue infections in pregnancy on the rise. The present study was aimed at determining dengue seroprevalence (IgG or IgM) during pregnancy and its neonatal transmission in dengue seropositive women. Methods. Maternal with paired cord blood samples were...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2014-01-01
|
| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2014/436975 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832567994917584896 |
|---|---|
| author | Nor Azlin Mohamed Ismail Wan Elly Rushima Wan Abd Rahim Sharifah Azura Salleh Hui-Min Neoh Rahman Jamal Muhammad Abdul Jamil |
| author_facet | Nor Azlin Mohamed Ismail Wan Elly Rushima Wan Abd Rahim Sharifah Azura Salleh Hui-Min Neoh Rahman Jamal Muhammad Abdul Jamil |
| author_sort | Nor Azlin Mohamed Ismail |
| collection | DOAJ |
| description | Purpose. Malaysia a dengue endemic country with dengue infections in pregnancy on the rise. The present study was aimed at determining dengue seroprevalence (IgG or IgM) during pregnancy and its neonatal transmission in dengue seropositive women. Methods. Maternal with paired cord blood samples were tested for dengue antibodies (IgG and IgM) using an enzyme-linked immunosorbent assay (ELISA). Maternal age, parity, occupation, ethnic group, and gestational age were recorded. Data on neonatal Apgar score and admissions to the Neonatal Intensive Care Unit (NICU) were analyzed. Results. Out of 358 women recruited, about 128 (35.8%) patients were seropositive. Twelve patients (3.4%) had recent infections (IgM positive) and another 116 women (32.4%) were with past infections (IgG positive). All babies born to seropositive mothers had positive IgG paired cord blood; however, no IgM seropositivity was observed. All neonates had good Apgar scores and did not require NICU admission. Conclusion. In this study, 35.8% pregnant women were found to be dengue seropositive. However, transplacental transfer of IgG antibodies had no detrimental effect on the neonatal outcomes. |
| format | Article |
| id | doaj-art-466bb91771104d92b5ef9b8002663b91 |
| institution | Kabale University |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-466bb91771104d92b5ef9b8002663b912025-02-03T00:59:56ZengWileyThe Scientific World Journal2356-61401537-744X2014-01-01201410.1155/2014/436975436975Seropositivity of Dengue Antibodies during PregnancyNor Azlin Mohamed Ismail0Wan Elly Rushima Wan Abd Rahim1Sharifah Azura Salleh2Hui-Min Neoh3Rahman Jamal4Muhammad Abdul Jamil5Department of Obstetrics & Gynaecology, Medical Faculty, Universiti Kebangsaan Malaysia, Jalan Yaacob Latiff, 56000 Cheras, Kuala Lumpur, MalaysiaDepartment of Obstetrics & Gynaecology, Medical Faculty, Universiti Kebangsaan Malaysia, Jalan Yaacob Latiff, 56000 Cheras, Kuala Lumpur, MalaysiaDepartment of Microbiology, Medical Faculty, Universiti Kebangsaan Malaysia, Jalan Yaacob Latiff, 56000 Cheras, Kuala Lumpur, MalaysiaUKM Medical Molecular Biology Institute, Medical Faculty, Universiti Kebangsaan Malaysia, Jalan Yaacob Latiff, 56000 Cheras, Kuala Lumpur, MalaysiaUKM Medical Molecular Biology Institute, Medical Faculty, Universiti Kebangsaan Malaysia, Jalan Yaacob Latiff, 56000 Cheras, Kuala Lumpur, MalaysiaDepartment of Obstetrics & Gynaecology, Medical Faculty, Universiti Kebangsaan Malaysia, Jalan Yaacob Latiff, 56000 Cheras, Kuala Lumpur, MalaysiaPurpose. Malaysia a dengue endemic country with dengue infections in pregnancy on the rise. The present study was aimed at determining dengue seroprevalence (IgG or IgM) during pregnancy and its neonatal transmission in dengue seropositive women. Methods. Maternal with paired cord blood samples were tested for dengue antibodies (IgG and IgM) using an enzyme-linked immunosorbent assay (ELISA). Maternal age, parity, occupation, ethnic group, and gestational age were recorded. Data on neonatal Apgar score and admissions to the Neonatal Intensive Care Unit (NICU) were analyzed. Results. Out of 358 women recruited, about 128 (35.8%) patients were seropositive. Twelve patients (3.4%) had recent infections (IgM positive) and another 116 women (32.4%) were with past infections (IgG positive). All babies born to seropositive mothers had positive IgG paired cord blood; however, no IgM seropositivity was observed. All neonates had good Apgar scores and did not require NICU admission. Conclusion. In this study, 35.8% pregnant women were found to be dengue seropositive. However, transplacental transfer of IgG antibodies had no detrimental effect on the neonatal outcomes.http://dx.doi.org/10.1155/2014/436975 |
| spellingShingle | Nor Azlin Mohamed Ismail Wan Elly Rushima Wan Abd Rahim Sharifah Azura Salleh Hui-Min Neoh Rahman Jamal Muhammad Abdul Jamil Seropositivity of Dengue Antibodies during Pregnancy The Scientific World Journal |
| title | Seropositivity of Dengue Antibodies during Pregnancy |
| title_full | Seropositivity of Dengue Antibodies during Pregnancy |
| title_fullStr | Seropositivity of Dengue Antibodies during Pregnancy |
| title_full_unstemmed | Seropositivity of Dengue Antibodies during Pregnancy |
| title_short | Seropositivity of Dengue Antibodies during Pregnancy |
| title_sort | seropositivity of dengue antibodies during pregnancy |
| url | http://dx.doi.org/10.1155/2014/436975 |
| work_keys_str_mv | AT norazlinmohamedismail seropositivityofdengueantibodiesduringpregnancy AT wanellyrushimawanabdrahim seropositivityofdengueantibodiesduringpregnancy AT sharifahazurasalleh seropositivityofdengueantibodiesduringpregnancy AT huiminneoh seropositivityofdengueantibodiesduringpregnancy AT rahmanjamal seropositivityofdengueantibodiesduringpregnancy AT muhammadabduljamil seropositivityofdengueantibodiesduringpregnancy |