A Case of Severe Asthma with Eosinophilic Otitis Media Successfully Treated with Anti-IgE Monoclonal Antibody Omalizumab
A 51-year-old woman had been receiving medical treatment for asthma since she was 21 years old. However, her asthma was poorly controlled despite treatment involving combination inhalation of high-dose corticosteroid and long-acting β2-aderenergic agonist (LABA) and regularly taking oral steroids. H...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Case Reports in Pulmonology |
| Online Access: | http://dx.doi.org/10.1155/2012/340525 |
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| _version_ | 1832567647412158464 |
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| author | Azusa Okude Etsuko Tagaya Mitsuko Kondo Manabu Nonaka Jun Tamaoki |
| author_facet | Azusa Okude Etsuko Tagaya Mitsuko Kondo Manabu Nonaka Jun Tamaoki |
| author_sort | Azusa Okude |
| collection | DOAJ |
| description | A 51-year-old woman had been receiving medical treatment for asthma since she was 21 years old. However, her asthma was poorly controlled despite treatment involving combination inhalation of high-dose corticosteroid and long-acting β2-aderenergic agonist (LABA) and regularly taking oral steroids. Hearing loss and otorrhea appeared at the age of 44, and she was given a diagnosis of eosinophilic otitis media (EOM) and received medical treatment. In 2007, symptoms of asthma and otitis media deteriorated. In December 2009, omalizumab therapy was started for refractory asthma. After 2 months of omalizumab treatment, not only asthma, but also hearing loss improved. It is suggested that early initiation of omalizumab therapy may inhibit the progression of progressive EOM. |
| format | Article |
| id | doaj-art-466b298ca1e147b7938704f41084706f |
| institution | Kabale University |
| issn | 2090-6846 2090-6854 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pulmonology |
| spelling | doaj-art-466b298ca1e147b7938704f41084706f2025-02-03T01:00:52ZengWileyCase Reports in Pulmonology2090-68462090-68542012-01-01201210.1155/2012/340525340525A Case of Severe Asthma with Eosinophilic Otitis Media Successfully Treated with Anti-IgE Monoclonal Antibody OmalizumabAzusa Okude0Etsuko Tagaya1Mitsuko Kondo2Manabu Nonaka3Jun Tamaoki4First Department of Medicine, School of Medicine, Tokyo Women’s Medical University, 8-1 Kawada-Cho, Shinjuku-ku, Tokyo 162-8666, JapanFirst Department of Medicine, School of Medicine, Tokyo Women’s Medical University, 8-1 Kawada-Cho, Shinjuku-ku, Tokyo 162-8666, JapanFirst Department of Medicine, School of Medicine, Tokyo Women’s Medical University, 8-1 Kawada-Cho, Shinjuku-ku, Tokyo 162-8666, JapanDepartment of Otolaryngology, School of Medicine, Tokyo Women’s Medical University, 8-1 Kawada-Cho, Shinjuku-ku, Tokyo 162-8666, JapanFirst Department of Medicine, School of Medicine, Tokyo Women’s Medical University, 8-1 Kawada-Cho, Shinjuku-ku, Tokyo 162-8666, JapanA 51-year-old woman had been receiving medical treatment for asthma since she was 21 years old. However, her asthma was poorly controlled despite treatment involving combination inhalation of high-dose corticosteroid and long-acting β2-aderenergic agonist (LABA) and regularly taking oral steroids. Hearing loss and otorrhea appeared at the age of 44, and she was given a diagnosis of eosinophilic otitis media (EOM) and received medical treatment. In 2007, symptoms of asthma and otitis media deteriorated. In December 2009, omalizumab therapy was started for refractory asthma. After 2 months of omalizumab treatment, not only asthma, but also hearing loss improved. It is suggested that early initiation of omalizumab therapy may inhibit the progression of progressive EOM.http://dx.doi.org/10.1155/2012/340525 |
| spellingShingle | Azusa Okude Etsuko Tagaya Mitsuko Kondo Manabu Nonaka Jun Tamaoki A Case of Severe Asthma with Eosinophilic Otitis Media Successfully Treated with Anti-IgE Monoclonal Antibody Omalizumab Case Reports in Pulmonology |
| title | A Case of Severe Asthma with Eosinophilic Otitis Media Successfully Treated with Anti-IgE Monoclonal Antibody Omalizumab |
| title_full | A Case of Severe Asthma with Eosinophilic Otitis Media Successfully Treated with Anti-IgE Monoclonal Antibody Omalizumab |
| title_fullStr | A Case of Severe Asthma with Eosinophilic Otitis Media Successfully Treated with Anti-IgE Monoclonal Antibody Omalizumab |
| title_full_unstemmed | A Case of Severe Asthma with Eosinophilic Otitis Media Successfully Treated with Anti-IgE Monoclonal Antibody Omalizumab |
| title_short | A Case of Severe Asthma with Eosinophilic Otitis Media Successfully Treated with Anti-IgE Monoclonal Antibody Omalizumab |
| title_sort | case of severe asthma with eosinophilic otitis media successfully treated with anti ige monoclonal antibody omalizumab |
| url | http://dx.doi.org/10.1155/2012/340525 |
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