Incidence and Predictors of Outcome in the Treatment of In-Stent Restenosis with Drug-Eluting Balloons, a Real-Life Single-Centre Study
Objectives. To determine the one-year and five-year occurrence and prognosticators of major adverse cardiac events (MACE: composition of all-cause death, myocardial infarction, target vessel revascularization, and vessel thrombosis), mortality, and target lesion revascularization (TLR) in patients w...
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| Format: | Article |
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Wiley
2022-01-01
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| Series: | Journal of Interventional Cardiology |
| Online Access: | http://dx.doi.org/10.1155/2022/1395980 |
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| author | Kyle Murnaghan Helen Bishop Navjot Sandila Bakhtiar Kidwai Lawrence Title Ata Ur Rehman Quraishi Catherine Kells Hussein Beydoun Osama Elkhateeb |
| author_facet | Kyle Murnaghan Helen Bishop Navjot Sandila Bakhtiar Kidwai Lawrence Title Ata Ur Rehman Quraishi Catherine Kells Hussein Beydoun Osama Elkhateeb |
| author_sort | Kyle Murnaghan |
| collection | DOAJ |
| description | Objectives. To determine the one-year and five-year occurrence and prognosticators of major adverse cardiac events (MACE: composition of all-cause death, myocardial infarction, target vessel revascularization, and vessel thrombosis), mortality, and target lesion revascularization (TLR) in patients with in-stent restenosis (ISR) treated with drug-eluting balloons (DEBs). Background. DEBs have become an emerging therapeutic option for ISR. We report the results of a single-center retrospective study on the treatment of ISR with DEB. Methods. 94 consecutive patients with ISR treated with the paclitaxel-eluting balloon were retrospectively studied between August 2011 and December 2019. Results. The one-year MACE rate was 11.8%, and the five-year MACE rate was 39.8%. The one-year mortality was 5.3%, and the five-year mortality rate was 21.5%. The one-year TLR rate was 4.3%, and the five-year rate was 18.7%. The univariable-Cox proportional hazard models for TLR showed lesion length, and the number of DEBs per vessel is associated with adverse outcomes with H.R. of 1.038 (1.007–1.069) and 4.7 (1.6–13.8), respectively. Conclusion. Our data indicate that at one year, DEBs provide an effective alternative to stenting for in-stent restenosis. Our five-year data, representing one of the longest-term follow-ups of DEB use, demonstrate high rates of MACE. The high five-year MACE reflects all-cause mortality in a high-risk population. This is offset by a reasonable five-year rate of TLR, indicating that DEB provides both short-term and long-term benefits in ISR. |
| format | Article |
| id | doaj-art-466991e1c6cf44e19563fc9018436c92 |
| institution | Kabale University |
| issn | 1540-8183 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Interventional Cardiology |
| spelling | doaj-art-466991e1c6cf44e19563fc9018436c922025-02-03T01:24:11ZengWileyJournal of Interventional Cardiology1540-81832022-01-01202210.1155/2022/1395980Incidence and Predictors of Outcome in the Treatment of In-Stent Restenosis with Drug-Eluting Balloons, a Real-Life Single-Centre StudyKyle Murnaghan0Helen Bishop1Navjot Sandila2Bakhtiar Kidwai3Lawrence Title4Ata Ur Rehman Quraishi5Catherine Kells6Hussein Beydoun7Osama Elkhateeb8Nova Scotia Health AuthorityNova Scotia Health AuthorityNova Scotia Health AuthorityNova Scotia Health AuthorityNova Scotia Health AuthorityNova Scotia Health AuthorityNova Scotia Health AuthorityNova Scotia Health AuthorityNova Scotia Health AuthorityObjectives. To determine the one-year and five-year occurrence and prognosticators of major adverse cardiac events (MACE: composition of all-cause death, myocardial infarction, target vessel revascularization, and vessel thrombosis), mortality, and target lesion revascularization (TLR) in patients with in-stent restenosis (ISR) treated with drug-eluting balloons (DEBs). Background. DEBs have become an emerging therapeutic option for ISR. We report the results of a single-center retrospective study on the treatment of ISR with DEB. Methods. 94 consecutive patients with ISR treated with the paclitaxel-eluting balloon were retrospectively studied between August 2011 and December 2019. Results. The one-year MACE rate was 11.8%, and the five-year MACE rate was 39.8%. The one-year mortality was 5.3%, and the five-year mortality rate was 21.5%. The one-year TLR rate was 4.3%, and the five-year rate was 18.7%. The univariable-Cox proportional hazard models for TLR showed lesion length, and the number of DEBs per vessel is associated with adverse outcomes with H.R. of 1.038 (1.007–1.069) and 4.7 (1.6–13.8), respectively. Conclusion. Our data indicate that at one year, DEBs provide an effective alternative to stenting for in-stent restenosis. Our five-year data, representing one of the longest-term follow-ups of DEB use, demonstrate high rates of MACE. The high five-year MACE reflects all-cause mortality in a high-risk population. This is offset by a reasonable five-year rate of TLR, indicating that DEB provides both short-term and long-term benefits in ISR.http://dx.doi.org/10.1155/2022/1395980 |
| spellingShingle | Kyle Murnaghan Helen Bishop Navjot Sandila Bakhtiar Kidwai Lawrence Title Ata Ur Rehman Quraishi Catherine Kells Hussein Beydoun Osama Elkhateeb Incidence and Predictors of Outcome in the Treatment of In-Stent Restenosis with Drug-Eluting Balloons, a Real-Life Single-Centre Study Journal of Interventional Cardiology |
| title | Incidence and Predictors of Outcome in the Treatment of In-Stent Restenosis with Drug-Eluting Balloons, a Real-Life Single-Centre Study |
| title_full | Incidence and Predictors of Outcome in the Treatment of In-Stent Restenosis with Drug-Eluting Balloons, a Real-Life Single-Centre Study |
| title_fullStr | Incidence and Predictors of Outcome in the Treatment of In-Stent Restenosis with Drug-Eluting Balloons, a Real-Life Single-Centre Study |
| title_full_unstemmed | Incidence and Predictors of Outcome in the Treatment of In-Stent Restenosis with Drug-Eluting Balloons, a Real-Life Single-Centre Study |
| title_short | Incidence and Predictors of Outcome in the Treatment of In-Stent Restenosis with Drug-Eluting Balloons, a Real-Life Single-Centre Study |
| title_sort | incidence and predictors of outcome in the treatment of in stent restenosis with drug eluting balloons a real life single centre study |
| url | http://dx.doi.org/10.1155/2022/1395980 |
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