Elevated expression of ANTXR1 gene in tumors is a poor prognostic biomarker for patients with bladder cancer
The TEM8 protein coded by the ANTXR1 gene represents an emerging biomarker in solid tumors. In addition to the various roles TEM8 plays in oncogenesis, including angiogenesis, epithelial-to-mesenchymal transition, and cell migration, it has also been shown that the overexpression of the ANTXR1 gene...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Molecular Biosciences |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmolb.2024.1520223/full |
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| author | L. S. Franco S. Arunachalam A. Chauhan S. A. Kareff P. L. Hallenbeck |
| author_facet | L. S. Franco S. Arunachalam A. Chauhan S. A. Kareff P. L. Hallenbeck |
| author_sort | L. S. Franco |
| collection | DOAJ |
| description | The TEM8 protein coded by the ANTXR1 gene represents an emerging biomarker in solid tumors. In addition to the various roles TEM8 plays in oncogenesis, including angiogenesis, epithelial-to-mesenchymal transition, and cell migration, it has also been shown that the overexpression of the ANTXR1 gene in solid tumors correlates with poor prognostic indicators in several solid tumor histologies. As such, TEM8 has been identified as the target of novel oncologic therapies. It is especially attractive given its selective expression on the surface of solid tumor cells and associated stromal cells, such as cancer stem cells, invasive cancer cells, and immune cells, such as macrophages, angiogenic endothelial cells, pericytes, and cancer-associated fibroblasts. Furthermore, TEM8 plays this unique role as a mostly non-mutated gene in solid cancers. Here, we demonstrate that elevated expression of ANTXR1 in bladder cancer showed a statistical difference not only in overall survival (OS) but in progression-free survival (PFS), confirming the prognostic biomarker power of ANTXR1 expression. |
| format | Article |
| id | doaj-art-46686fb5348844bb9a26c379796d7a71 |
| institution | Kabale University |
| issn | 2296-889X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Biosciences |
| spelling | doaj-art-46686fb5348844bb9a26c379796d7a712025-01-23T05:10:30ZengFrontiers Media S.A.Frontiers in Molecular Biosciences2296-889X2025-01-011110.3389/fmolb.2024.15202231520223Elevated expression of ANTXR1 gene in tumors is a poor prognostic biomarker for patients with bladder cancerL. S. Franco0S. Arunachalam1A. Chauhan2S. A. Kareff3P. L. Hallenbeck4Seneca Therapeutics, Inc., Blue Bell, PA, United StatesSeneca Therapeutics, Inc., Blue Bell, PA, United StatesSylvester Comprehensive Cancer Center, University of Miami Health System, Miami, FL, United StatesLynn Cancer Institute, Boca Raton Regional Hospital, Boca Raton, FL, United StatesSeneca Therapeutics, Inc., Blue Bell, PA, United StatesThe TEM8 protein coded by the ANTXR1 gene represents an emerging biomarker in solid tumors. In addition to the various roles TEM8 plays in oncogenesis, including angiogenesis, epithelial-to-mesenchymal transition, and cell migration, it has also been shown that the overexpression of the ANTXR1 gene in solid tumors correlates with poor prognostic indicators in several solid tumor histologies. As such, TEM8 has been identified as the target of novel oncologic therapies. It is especially attractive given its selective expression on the surface of solid tumor cells and associated stromal cells, such as cancer stem cells, invasive cancer cells, and immune cells, such as macrophages, angiogenic endothelial cells, pericytes, and cancer-associated fibroblasts. Furthermore, TEM8 plays this unique role as a mostly non-mutated gene in solid cancers. Here, we demonstrate that elevated expression of ANTXR1 in bladder cancer showed a statistical difference not only in overall survival (OS) but in progression-free survival (PFS), confirming the prognostic biomarker power of ANTXR1 expression.https://www.frontiersin.org/articles/10.3389/fmolb.2024.1520223/fullTEM8prognostic biomarkerbladder cancerdownstream pathwaysurvival |
| spellingShingle | L. S. Franco S. Arunachalam A. Chauhan S. A. Kareff P. L. Hallenbeck Elevated expression of ANTXR1 gene in tumors is a poor prognostic biomarker for patients with bladder cancer Frontiers in Molecular Biosciences TEM8 prognostic biomarker bladder cancer downstream pathway survival |
| title | Elevated expression of ANTXR1 gene in tumors is a poor prognostic biomarker for patients with bladder cancer |
| title_full | Elevated expression of ANTXR1 gene in tumors is a poor prognostic biomarker for patients with bladder cancer |
| title_fullStr | Elevated expression of ANTXR1 gene in tumors is a poor prognostic biomarker for patients with bladder cancer |
| title_full_unstemmed | Elevated expression of ANTXR1 gene in tumors is a poor prognostic biomarker for patients with bladder cancer |
| title_short | Elevated expression of ANTXR1 gene in tumors is a poor prognostic biomarker for patients with bladder cancer |
| title_sort | elevated expression of antxr1 gene in tumors is a poor prognostic biomarker for patients with bladder cancer |
| topic | TEM8 prognostic biomarker bladder cancer downstream pathway survival |
| url | https://www.frontiersin.org/articles/10.3389/fmolb.2024.1520223/full |
| work_keys_str_mv | AT lsfranco elevatedexpressionofantxr1geneintumorsisapoorprognosticbiomarkerforpatientswithbladdercancer AT sarunachalam elevatedexpressionofantxr1geneintumorsisapoorprognosticbiomarkerforpatientswithbladdercancer AT achauhan elevatedexpressionofantxr1geneintumorsisapoorprognosticbiomarkerforpatientswithbladdercancer AT sakareff elevatedexpressionofantxr1geneintumorsisapoorprognosticbiomarkerforpatientswithbladdercancer AT plhallenbeck elevatedexpressionofantxr1geneintumorsisapoorprognosticbiomarkerforpatientswithbladdercancer |