Chinese Torreya grandis cv. Merrillii seed oil affects obesity through accumulation of sciadonic acid and altering the composition of gut microbiota
Torreya grandis cv. Merrillii (Taxace, Torreya) is mainly distributed across the hilly areas of subtropical China and is well known for its nutritional value. In this study, the ameliorative effects of T. grandis seed oil on lipid metabolism were investigated, and the underlying mechanism was explor...
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Tsinghua University Press
2022-01-01
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| Series: | Food Science and Human Wellness |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213453021000732 |
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| author | Huan Wang Ye Li Rui Wang Huaifei Ji Chenyang Lu Xiurong Su |
| author_facet | Huan Wang Ye Li Rui Wang Huaifei Ji Chenyang Lu Xiurong Su |
| author_sort | Huan Wang |
| collection | DOAJ |
| description | Torreya grandis cv. Merrillii (Taxace, Torreya) is mainly distributed across the hilly areas of subtropical China and is well known for its nutritional value. In this study, the ameliorative effects of T. grandis seed oil on lipid metabolism were investigated, and the underlying mechanism was explored from the perspective of gut microbiota. Mice experiments showed that the rate of body mass gain in the group where the mice were fed a high-fat diet (HFD) and supplemented with 550 mg/(kg·day) T. grandis seed oil (HFD + TO550 group) was 42.27%, while it was 62.25% in the HFD group. Compared with the HFD group, the liver and fat indices, total cholesterol, triglycerides, and low-density lipoprotein cholesterol were reduced in the oil-supplement groups. Moreover, the oil supplement significantly changed the fatty acid composition and alleviated pathological damage to the liver caused by the high-fat diet. Additionally, the distinct clustering of bacteria in the composition of gut microbiota was observed in the oil treatment group compared with that in the HFD group. T. grandis seed oil significantly increased the abundance of the beneficial bacteria and short-chain fatty acid producers, including Lactobacillus, Bifidobacterium, Faecalibaculum and Allobaculum. Our results suggest that the supplements of T. grandis seed oil could alleviate hyperlipidemia caused by HFD. These positive effects are considered to be related with sciadonic acid (SCA) and are partially mediated by alterations in gut microbiota composition and functionality. |
| format | Article |
| id | doaj-art-4663933b39454235bf5b4e3e928f125c |
| institution | Kabale University |
| issn | 2213-4530 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Tsinghua University Press |
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| series | Food Science and Human Wellness |
| spelling | doaj-art-4663933b39454235bf5b4e3e928f125c2025-02-03T04:06:17ZengTsinghua University PressFood Science and Human Wellness2213-45302022-01-011115867Chinese Torreya grandis cv. Merrillii seed oil affects obesity through accumulation of sciadonic acid and altering the composition of gut microbiotaHuan Wang0Ye Li1Rui Wang2Huaifei Ji3Chenyang Lu4Xiurong Su5State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products, Ningbo University, Ningbo 315211, China; Collage of Food and Pharmaceutical Sciences, Ningbo University, Ningbo 315800, ChinaState Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products, Ningbo University, Ningbo 315211, China; Collage of Marine Science, Ningbo University, Ningbo 315800, China; Corresponding author at: Collage of Marine Science, Ningbo University, Ningbo 315800, China.State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products, Ningbo University, Ningbo 315211, China; Collage of Food and Pharmaceutical Sciences, Ningbo University, Ningbo 315800, ChinaState Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products, Ningbo University, Ningbo 315211, China; Collage of Food and Pharmaceutical Sciences, Ningbo University, Ningbo 315800, ChinaState Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products, Ningbo University, Ningbo 315211, China; Collage of Marine Science, Ningbo University, Ningbo 315800, ChinaState Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products, Ningbo University, Ningbo 315211, China; Collage of Marine Science, Ningbo University, Ningbo 315800, ChinaTorreya grandis cv. Merrillii (Taxace, Torreya) is mainly distributed across the hilly areas of subtropical China and is well known for its nutritional value. In this study, the ameliorative effects of T. grandis seed oil on lipid metabolism were investigated, and the underlying mechanism was explored from the perspective of gut microbiota. Mice experiments showed that the rate of body mass gain in the group where the mice were fed a high-fat diet (HFD) and supplemented with 550 mg/(kg·day) T. grandis seed oil (HFD + TO550 group) was 42.27%, while it was 62.25% in the HFD group. Compared with the HFD group, the liver and fat indices, total cholesterol, triglycerides, and low-density lipoprotein cholesterol were reduced in the oil-supplement groups. Moreover, the oil supplement significantly changed the fatty acid composition and alleviated pathological damage to the liver caused by the high-fat diet. Additionally, the distinct clustering of bacteria in the composition of gut microbiota was observed in the oil treatment group compared with that in the HFD group. T. grandis seed oil significantly increased the abundance of the beneficial bacteria and short-chain fatty acid producers, including Lactobacillus, Bifidobacterium, Faecalibaculum and Allobaculum. Our results suggest that the supplements of T. grandis seed oil could alleviate hyperlipidemia caused by HFD. These positive effects are considered to be related with sciadonic acid (SCA) and are partially mediated by alterations in gut microbiota composition and functionality.http://www.sciencedirect.com/science/article/pii/S2213453021000732Torreya grandis cv. Merrillii seed oilObesityLipid metabolismGut microbiota |
| spellingShingle | Huan Wang Ye Li Rui Wang Huaifei Ji Chenyang Lu Xiurong Su Chinese Torreya grandis cv. Merrillii seed oil affects obesity through accumulation of sciadonic acid and altering the composition of gut microbiota Food Science and Human Wellness Torreya grandis cv. Merrillii seed oil Obesity Lipid metabolism Gut microbiota |
| title | Chinese Torreya grandis cv. Merrillii seed oil affects obesity through accumulation of sciadonic acid and altering the composition of gut microbiota |
| title_full | Chinese Torreya grandis cv. Merrillii seed oil affects obesity through accumulation of sciadonic acid and altering the composition of gut microbiota |
| title_fullStr | Chinese Torreya grandis cv. Merrillii seed oil affects obesity through accumulation of sciadonic acid and altering the composition of gut microbiota |
| title_full_unstemmed | Chinese Torreya grandis cv. Merrillii seed oil affects obesity through accumulation of sciadonic acid and altering the composition of gut microbiota |
| title_short | Chinese Torreya grandis cv. Merrillii seed oil affects obesity through accumulation of sciadonic acid and altering the composition of gut microbiota |
| title_sort | chinese torreya grandis cv merrillii seed oil affects obesity through accumulation of sciadonic acid and altering the composition of gut microbiota |
| topic | Torreya grandis cv. Merrillii seed oil Obesity Lipid metabolism Gut microbiota |
| url | http://www.sciencedirect.com/science/article/pii/S2213453021000732 |
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