Blood Cells Parameters in Second Trimester of Pregnancy and Gestational Diabetes Mellitus: A Systematic Review and Meta‐Analysis
ABSTRACT Objective Gestational diabetes mellitus (GDM) is one of the most common complications during pregnancy. There is inconsistency between previous studies regarding the blood and inflammatory parameters levels among pregnant women and its association with GDM. This study aimed to investigate t...
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Wiley
2025-01-01
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| Series: | Endocrinology, Diabetes & Metabolism |
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| Online Access: | https://doi.org/10.1002/edm2.70024 |
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| author | Vida Ghasemi Mojdeh Banaei Zahra Kiani Fahimeh Ramezani Tehrani Marzieh Saei Ghare Naz |
| author_facet | Vida Ghasemi Mojdeh Banaei Zahra Kiani Fahimeh Ramezani Tehrani Marzieh Saei Ghare Naz |
| author_sort | Vida Ghasemi |
| collection | DOAJ |
| description | ABSTRACT Objective Gestational diabetes mellitus (GDM) is one of the most common complications during pregnancy. There is inconsistency between previous studies regarding the blood and inflammatory parameters levels among pregnant women and its association with GDM. This study aimed to investigate the relationship between blood parameters in relation to GDM. Methods Systematic literature searches were carried out through databases like PubMed, Web of Science, Epistemonikos, Scopus, Scientific Information Database and Magiran till May 2024. The effect size of serum blood parameters levels was determined by using standard mean deviations (SMDs) and 95% confidence intervals (CIs). Results Thirty articles were included in this study. Meta‐analysis showed that compared with the control group, women with GDM had significantly higher levels of haemoglobin (0.343 [95% CI 0.134–0.553] p = 0.01, sensitivity analysis: 0.174 [95% CI 0.0343–0.315] p = 0.01), red blood cell (0.387 [95% CI 0.224–0.550] p < 0.001), mean platelet volume (0.498 [95% CI 0.165–0.831] p = 0.003), white blood cell count (0.351 [95% CI 0.0882–0.615] p = 0.009) and neutrophil–lymphocyte ratio (0.534 [95% CI 0.127–0.941] p = 0.01). However, women with GDM had lower levels of mean corpuscular haemoglobin concentration (−0.249 [95% CI −0.386–−0.112] p < 0.001). Pooled results from MPV showed no association between adjusted MPV and GDM (adjusted OR 1.33 [95% CI 0.8–1.86] I2 = 57.2%). Conclusions Finding supports higher levels of blood parameters (Hb, RBC, WBC, NLR and MPV) among women with GDM in the second trimester of pregnancy. Future studies should investigate the potential role of these haematological markers as predictive tools for adverse pregnancy outcomes and evaluate therapeutic interventions targeting these parameters to enhance maternal and fetal health. |
| format | Article |
| id | doaj-art-46627c81a91b4c578b8032a6caa31482 |
| institution | Kabale University |
| issn | 2398-9238 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
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| series | Endocrinology, Diabetes & Metabolism |
| spelling | doaj-art-46627c81a91b4c578b8032a6caa314822025-01-25T18:20:28ZengWileyEndocrinology, Diabetes & Metabolism2398-92382025-01-0181n/an/a10.1002/edm2.70024Blood Cells Parameters in Second Trimester of Pregnancy and Gestational Diabetes Mellitus: A Systematic Review and Meta‐AnalysisVida Ghasemi0Mojdeh Banaei1Zahra Kiani2Fahimeh Ramezani Tehrani3Marzieh Saei Ghare Naz4Department of Public Health Asadabad School of Medical Sciences Asadabad IranMother and Child Welfare Research Center Hormozgan University of Medical Sciences Bandar Abbas IranMidwifery and Reproductive Health Research Center Shahid Beheshti University of Medical Sciences Tehran IranReproductive Endocrinology Research Center Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences Tehran IranReproductive Endocrinology Research Center Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences Tehran IranABSTRACT Objective Gestational diabetes mellitus (GDM) is one of the most common complications during pregnancy. There is inconsistency between previous studies regarding the blood and inflammatory parameters levels among pregnant women and its association with GDM. This study aimed to investigate the relationship between blood parameters in relation to GDM. Methods Systematic literature searches were carried out through databases like PubMed, Web of Science, Epistemonikos, Scopus, Scientific Information Database and Magiran till May 2024. The effect size of serum blood parameters levels was determined by using standard mean deviations (SMDs) and 95% confidence intervals (CIs). Results Thirty articles were included in this study. Meta‐analysis showed that compared with the control group, women with GDM had significantly higher levels of haemoglobin (0.343 [95% CI 0.134–0.553] p = 0.01, sensitivity analysis: 0.174 [95% CI 0.0343–0.315] p = 0.01), red blood cell (0.387 [95% CI 0.224–0.550] p < 0.001), mean platelet volume (0.498 [95% CI 0.165–0.831] p = 0.003), white blood cell count (0.351 [95% CI 0.0882–0.615] p = 0.009) and neutrophil–lymphocyte ratio (0.534 [95% CI 0.127–0.941] p = 0.01). However, women with GDM had lower levels of mean corpuscular haemoglobin concentration (−0.249 [95% CI −0.386–−0.112] p < 0.001). Pooled results from MPV showed no association between adjusted MPV and GDM (adjusted OR 1.33 [95% CI 0.8–1.86] I2 = 57.2%). Conclusions Finding supports higher levels of blood parameters (Hb, RBC, WBC, NLR and MPV) among women with GDM in the second trimester of pregnancy. Future studies should investigate the potential role of these haematological markers as predictive tools for adverse pregnancy outcomes and evaluate therapeutic interventions targeting these parameters to enhance maternal and fetal health.https://doi.org/10.1002/edm2.70024blood parametersgestational diabeteshaemoglobinmeta‐analysisplateletwhite blood cells |
| spellingShingle | Vida Ghasemi Mojdeh Banaei Zahra Kiani Fahimeh Ramezani Tehrani Marzieh Saei Ghare Naz Blood Cells Parameters in Second Trimester of Pregnancy and Gestational Diabetes Mellitus: A Systematic Review and Meta‐Analysis Endocrinology, Diabetes & Metabolism blood parameters gestational diabetes haemoglobin meta‐analysis platelet white blood cells |
| title | Blood Cells Parameters in Second Trimester of Pregnancy and Gestational Diabetes Mellitus: A Systematic Review and Meta‐Analysis |
| title_full | Blood Cells Parameters in Second Trimester of Pregnancy and Gestational Diabetes Mellitus: A Systematic Review and Meta‐Analysis |
| title_fullStr | Blood Cells Parameters in Second Trimester of Pregnancy and Gestational Diabetes Mellitus: A Systematic Review and Meta‐Analysis |
| title_full_unstemmed | Blood Cells Parameters in Second Trimester of Pregnancy and Gestational Diabetes Mellitus: A Systematic Review and Meta‐Analysis |
| title_short | Blood Cells Parameters in Second Trimester of Pregnancy and Gestational Diabetes Mellitus: A Systematic Review and Meta‐Analysis |
| title_sort | blood cells parameters in second trimester of pregnancy and gestational diabetes mellitus a systematic review and meta analysis |
| topic | blood parameters gestational diabetes haemoglobin meta‐analysis platelet white blood cells |
| url | https://doi.org/10.1002/edm2.70024 |
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