Synthesis, Characterization of Some Novel Benzimidazole Derivatives of 1-Bromo-2,4-dinitrobenzene and Their Antifungal Activities
Six novel benzimidazole derivatives, 5-nitro-2-phenyl -1-ethyl benzimidazol (5), 2- (p-bromophenyl)- 5-nitro- 1-ethyl benzimidazol (6), 2- (p-bromophenyl-5-nitro-1–cyclopentyl benzimidazol (7), 2- (p-bromophenyl) -5-nitro-1-cyclopentyl benzimidazol (8), 5-amino-2-(p-bromophenyl)-1-ethylbenzimidazol...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | E-Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2011/685246 |
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| author | Abbas Ahmadi Babak Nahri-Niknafs |
| author_facet | Abbas Ahmadi Babak Nahri-Niknafs |
| author_sort | Abbas Ahmadi |
| collection | DOAJ |
| description | Six novel benzimidazole derivatives, 5-nitro-2-phenyl -1-ethyl benzimidazol (5), 2- (p-bromophenyl)- 5-nitro- 1-ethyl benzimidazol (6), 2- (p-bromophenyl-5-nitro-1–cyclopentyl benzimidazol (7), 2- (p-bromophenyl) -5-nitro-1-cyclopentyl benzimidazol (8), 5-amino-2-(p-bromophenyl)-1-ethylbenzimidazol (9) and 5-amino-2-(p-bromophenyl)-1-cyclopentyl benzimidazol (10) were synthesized. The structures of all the synthesized compounds were elucidated by using elemental analysis and different spectroscopic techniques (IR, NMR and mass spectroscopy). Some of these compounds showed potential antifungal activities. The biological activity of these compounds as fungicides was tested against Candida albicans, patient isolate Candida glabrata and Candida krusei. The biological activity of four compounds was found to be comparable to that of the commercially available fungicides with a minimum inhibitory concentration of 12.5 µg/mL. |
| format | Article |
| id | doaj-art-466117811a8e4c46ac4e529f3addfbc7 |
| institution | Kabale University |
| issn | 0973-4945 2090-9810 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | E-Journal of Chemistry |
| spelling | doaj-art-466117811a8e4c46ac4e529f3addfbc72025-02-03T01:30:08ZengWileyE-Journal of Chemistry0973-49452090-98102011-01-018S1S85S9010.1155/2011/685246Synthesis, Characterization of Some Novel Benzimidazole Derivatives of 1-Bromo-2,4-dinitrobenzene and Their Antifungal ActivitiesAbbas Ahmadi0Babak Nahri-Niknafs1Department of Chemistry, Faculty of Science, Islamic Azad University, Karaj baranch, Karaj, IranDepartment of Chemistry, Faculty of Science, Islamic Azad University, Karaj baranch, Karaj, IranSix novel benzimidazole derivatives, 5-nitro-2-phenyl -1-ethyl benzimidazol (5), 2- (p-bromophenyl)- 5-nitro- 1-ethyl benzimidazol (6), 2- (p-bromophenyl-5-nitro-1–cyclopentyl benzimidazol (7), 2- (p-bromophenyl) -5-nitro-1-cyclopentyl benzimidazol (8), 5-amino-2-(p-bromophenyl)-1-ethylbenzimidazol (9) and 5-amino-2-(p-bromophenyl)-1-cyclopentyl benzimidazol (10) were synthesized. The structures of all the synthesized compounds were elucidated by using elemental analysis and different spectroscopic techniques (IR, NMR and mass spectroscopy). Some of these compounds showed potential antifungal activities. The biological activity of these compounds as fungicides was tested against Candida albicans, patient isolate Candida glabrata and Candida krusei. The biological activity of four compounds was found to be comparable to that of the commercially available fungicides with a minimum inhibitory concentration of 12.5 µg/mL.http://dx.doi.org/10.1155/2011/685246 |
| spellingShingle | Abbas Ahmadi Babak Nahri-Niknafs Synthesis, Characterization of Some Novel Benzimidazole Derivatives of 1-Bromo-2,4-dinitrobenzene and Their Antifungal Activities E-Journal of Chemistry |
| title | Synthesis, Characterization of Some Novel Benzimidazole Derivatives of 1-Bromo-2,4-dinitrobenzene and Their Antifungal Activities |
| title_full | Synthesis, Characterization of Some Novel Benzimidazole Derivatives of 1-Bromo-2,4-dinitrobenzene and Their Antifungal Activities |
| title_fullStr | Synthesis, Characterization of Some Novel Benzimidazole Derivatives of 1-Bromo-2,4-dinitrobenzene and Their Antifungal Activities |
| title_full_unstemmed | Synthesis, Characterization of Some Novel Benzimidazole Derivatives of 1-Bromo-2,4-dinitrobenzene and Their Antifungal Activities |
| title_short | Synthesis, Characterization of Some Novel Benzimidazole Derivatives of 1-Bromo-2,4-dinitrobenzene and Their Antifungal Activities |
| title_sort | synthesis characterization of some novel benzimidazole derivatives of 1 bromo 2 4 dinitrobenzene and their antifungal activities |
| url | http://dx.doi.org/10.1155/2011/685246 |
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