The Role of Ion Channels in Pulmonary Hypertension: A Review
ABSTRACT Pulmonary hypertension (PH) constitutes a critical challenge in cardiopulmonary medicine with a pathogenesis that is multifaceted and intricate. Ion channels, crucial determinants of cellular electrochemical gradient modulation, have emerged as significant participants in the pathophysiolog...
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| Format: | Article |
| Language: | English |
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Wiley
2025-01-01
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| Series: | Pulmonary Circulation |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/pul2.70050 |
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| author | Han‐Fei Li Xin‐Yao Li Yu‐Qing Sun Ze‐Ying Zhi Liao‐Fan Song Meng Li Yi‐Ming Feng Zhi‐Hao Zhang Yan‐Feng Liu Yu‐Jing Chen Fan‐Rong Zhao Tian‐Tian Zhu |
| author_facet | Han‐Fei Li Xin‐Yao Li Yu‐Qing Sun Ze‐Ying Zhi Liao‐Fan Song Meng Li Yi‐Ming Feng Zhi‐Hao Zhang Yan‐Feng Liu Yu‐Jing Chen Fan‐Rong Zhao Tian‐Tian Zhu |
| author_sort | Han‐Fei Li |
| collection | DOAJ |
| description | ABSTRACT Pulmonary hypertension (PH) constitutes a critical challenge in cardiopulmonary medicine with a pathogenesis that is multifaceted and intricate. Ion channels, crucial determinants of cellular electrochemical gradient modulation, have emerged as significant participants in the pathophysiological progression of PH. These channels, abundant on the membranes of pulmonary artery smooth muscle cells (PASMCs) and pulmonary artery endothelial cells (PAECs), pivotally navigate the nuanced interplay of cell proliferation, migration, and endothelial function, each vital to the pulmonary vascular remodeling (PVR) hallmark of PH. Our review delves into the mechanistic insights of potassium, calcium, magnesium, zinc, and chloride ion channels in relation to their involvement in PH. It not only emphasizes the notable advances and discoveries that cast these ion channels as underlying factors in the etiology and exacerbation of PH but also highlights their potential as innovative therapeutic targets. |
| format | Article |
| id | doaj-art-465dd1d7d9b6436a9cc4d1a01bca76d2 |
| institution | OA Journals |
| issn | 2045-8940 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Pulmonary Circulation |
| spelling | doaj-art-465dd1d7d9b6436a9cc4d1a01bca76d22025-08-20T01:50:07ZengWileyPulmonary Circulation2045-89402025-01-01151n/an/a10.1002/pul2.70050The Role of Ion Channels in Pulmonary Hypertension: A ReviewHan‐Fei Li0Xin‐Yao Li1Yu‐Qing Sun2Ze‐Ying Zhi3Liao‐Fan Song4Meng Li5Yi‐Ming Feng6Zhi‐Hao Zhang7Yan‐Feng Liu8Yu‐Jing Chen9Fan‐Rong Zhao10Tian‐Tian Zhu11College of Pharmacy Xinxiang Medical University Xinxiang ChinaCollege of Pharmacy Xinxiang Medical University Xinxiang ChinaCollege of Pharmacy Xinxiang Medical University Xinxiang ChinaCollege of Pharmacy Xinxiang Medical University Xinxiang ChinaCollege of Pharmacy Xinxiang Medical University Xinxiang ChinaCollege of Pharmacy Xinxiang Medical University Xinxiang ChinaCollege of Pharmacy Xinxiang Medical University Xinxiang ChinaCollege of Pharmacy Xinxiang Medical University Xinxiang ChinaCollege of Pharmacy Xinxiang Medical University Xinxiang ChinaCollege of Pharmacy Xinxiang Medical University Xinxiang ChinaCollege of Pharmacy Xinxiang Medical University Xinxiang ChinaCollege of Pharmacy Xinxiang Medical University Xinxiang ChinaABSTRACT Pulmonary hypertension (PH) constitutes a critical challenge in cardiopulmonary medicine with a pathogenesis that is multifaceted and intricate. Ion channels, crucial determinants of cellular electrochemical gradient modulation, have emerged as significant participants in the pathophysiological progression of PH. These channels, abundant on the membranes of pulmonary artery smooth muscle cells (PASMCs) and pulmonary artery endothelial cells (PAECs), pivotally navigate the nuanced interplay of cell proliferation, migration, and endothelial function, each vital to the pulmonary vascular remodeling (PVR) hallmark of PH. Our review delves into the mechanistic insights of potassium, calcium, magnesium, zinc, and chloride ion channels in relation to their involvement in PH. It not only emphasizes the notable advances and discoveries that cast these ion channels as underlying factors in the etiology and exacerbation of PH but also highlights their potential as innovative therapeutic targets.https://doi.org/10.1002/pul2.70050calcium channelschloride channelsion channelsmagnesium channelspotassium channelspulmonary hypertension |
| spellingShingle | Han‐Fei Li Xin‐Yao Li Yu‐Qing Sun Ze‐Ying Zhi Liao‐Fan Song Meng Li Yi‐Ming Feng Zhi‐Hao Zhang Yan‐Feng Liu Yu‐Jing Chen Fan‐Rong Zhao Tian‐Tian Zhu The Role of Ion Channels in Pulmonary Hypertension: A Review Pulmonary Circulation calcium channels chloride channels ion channels magnesium channels potassium channels pulmonary hypertension |
| title | The Role of Ion Channels in Pulmonary Hypertension: A Review |
| title_full | The Role of Ion Channels in Pulmonary Hypertension: A Review |
| title_fullStr | The Role of Ion Channels in Pulmonary Hypertension: A Review |
| title_full_unstemmed | The Role of Ion Channels in Pulmonary Hypertension: A Review |
| title_short | The Role of Ion Channels in Pulmonary Hypertension: A Review |
| title_sort | role of ion channels in pulmonary hypertension a review |
| topic | calcium channels chloride channels ion channels magnesium channels potassium channels pulmonary hypertension |
| url | https://doi.org/10.1002/pul2.70050 |
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