Effect of non-surgical periodontal therapy on salivary and gingival crevicular fluid concentration of visfatin in periodontal health and disease
Background and objective: Visfatin, a pleotropic mediator mostly produced by visceral fat, is crucial in controlling the immunological and defensive systems. It serves the roles of a cytokine, an enzyme involved in energy metabolism, and a growth factor. The objective of the present study was to ass...
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Elsevier
2024-07-01
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| Series: | Journal of Oral Biology and Craniofacial Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2212426824000666 |
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| author | Hira Ismail Anjani Kumar Pathak Nand Lal Pavitra Rastogi Kaleem Ahmad Mohd. Aamir Khan |
| author_facet | Hira Ismail Anjani Kumar Pathak Nand Lal Pavitra Rastogi Kaleem Ahmad Mohd. Aamir Khan |
| author_sort | Hira Ismail |
| collection | DOAJ |
| description | Background and objective: Visfatin, a pleotropic mediator mostly produced by visceral fat, is crucial in controlling the immunological and defensive systems. It serves the roles of a cytokine, an enzyme involved in energy metabolism, and a growth factor. The objective of the present study was to assess the impact of non-surgical periodontal therapy (scaling and root planing) on visfatin concentrations in saliva and gingival crevicular fluid in individuals with Periodontitis (stage-II grade-A) Materials and methods: 54 individuals were divided into Group A (Periodontally Healthy) and Group B1(Periodontitis baseline) based on periodontal parameters including plaque index (PI), gingival index (GI), probing pocket depth (PPD), clinical attachment level (CAL), and radiographic parameters. After NSPT (SRP), Group B1 patients were recalled after 4 weeks, constituting Group B2 (post NSPT group B1). At baseline and 4 weeks after non-surgical periodontal therapy (SRP), all clinical parameters, salivary and GCF samples were recorded. An ELISA kit was used to measure the levels of visfatin. Using the paired t-test, unpaired t-test, and Pearson's correlation coefficient, data were analysed using SPSS 15. Results: After non-surgical periodontal treatment (SRP), the mean salivary and gingival crevicular fluid concentration of visfatin considerably decreased to a level comparable to periodontal health. In all groups, GCF visfatin concentration was higher than salivary concentration of visfatin. In periodontitis patients, visfatin concentration in GCF was 1.5 times higher than in saliva. Conclusion: The results of this investigation suggest a direct correlation between salivary and gingival crevicular fluid visfatin concentration and periodontal tissue inflammation and disease activity. |
| format | Article |
| id | doaj-art-465a08ec8e124e7d9d7d11d6ab919fd2 |
| institution | Kabale University |
| issn | 2212-4268 |
| language | English |
| publishDate | 2024-07-01 |
| publisher | Elsevier |
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| series | Journal of Oral Biology and Craniofacial Research |
| spelling | doaj-art-465a08ec8e124e7d9d7d11d6ab919fd22025-01-24T04:45:02ZengElsevierJournal of Oral Biology and Craniofacial Research2212-42682024-07-01144430434Effect of non-surgical periodontal therapy on salivary and gingival crevicular fluid concentration of visfatin in periodontal health and diseaseHira Ismail0Anjani Kumar Pathak1Nand Lal2Pavitra Rastogi3Kaleem Ahmad4Mohd. Aamir Khan5Department of Periodontology, Faculty of Dental Sciences, King George's Medical University, Uttar Pradesh, Lucknow, India; Corresponding author.Department of Periodontology, Faculty of Dental Sciences, King George's Medical University, Uttar Pradesh, Lucknow, IndiaDepartment of Periodontology, Faculty of Dental Sciences, King George's Medical University, Uttar Pradesh, Lucknow, IndiaDepartment of Periodontology, Faculty of Dental Sciences, King George's Medical University, Uttar Pradesh, Lucknow, IndiaDepartment of Biochemistry, King George's Medical University, Uttar Pradesh, Lucknow, IndiaDepartment of Periodontology, Faculty of Dental Sciences, King George's Medical University, Uttar Pradesh, Lucknow, IndiaBackground and objective: Visfatin, a pleotropic mediator mostly produced by visceral fat, is crucial in controlling the immunological and defensive systems. It serves the roles of a cytokine, an enzyme involved in energy metabolism, and a growth factor. The objective of the present study was to assess the impact of non-surgical periodontal therapy (scaling and root planing) on visfatin concentrations in saliva and gingival crevicular fluid in individuals with Periodontitis (stage-II grade-A) Materials and methods: 54 individuals were divided into Group A (Periodontally Healthy) and Group B1(Periodontitis baseline) based on periodontal parameters including plaque index (PI), gingival index (GI), probing pocket depth (PPD), clinical attachment level (CAL), and radiographic parameters. After NSPT (SRP), Group B1 patients were recalled after 4 weeks, constituting Group B2 (post NSPT group B1). At baseline and 4 weeks after non-surgical periodontal therapy (SRP), all clinical parameters, salivary and GCF samples were recorded. An ELISA kit was used to measure the levels of visfatin. Using the paired t-test, unpaired t-test, and Pearson's correlation coefficient, data were analysed using SPSS 15. Results: After non-surgical periodontal treatment (SRP), the mean salivary and gingival crevicular fluid concentration of visfatin considerably decreased to a level comparable to periodontal health. In all groups, GCF visfatin concentration was higher than salivary concentration of visfatin. In periodontitis patients, visfatin concentration in GCF was 1.5 times higher than in saliva. Conclusion: The results of this investigation suggest a direct correlation between salivary and gingival crevicular fluid visfatin concentration and periodontal tissue inflammation and disease activity.http://www.sciencedirect.com/science/article/pii/S2212426824000666VisfatinPeriodontitisSalivaGingival crevicular fluidNon-surgical periodontal therapyScaling and root planing |
| spellingShingle | Hira Ismail Anjani Kumar Pathak Nand Lal Pavitra Rastogi Kaleem Ahmad Mohd. Aamir Khan Effect of non-surgical periodontal therapy on salivary and gingival crevicular fluid concentration of visfatin in periodontal health and disease Journal of Oral Biology and Craniofacial Research Visfatin Periodontitis Saliva Gingival crevicular fluid Non-surgical periodontal therapy Scaling and root planing |
| title | Effect of non-surgical periodontal therapy on salivary and gingival crevicular fluid concentration of visfatin in periodontal health and disease |
| title_full | Effect of non-surgical periodontal therapy on salivary and gingival crevicular fluid concentration of visfatin in periodontal health and disease |
| title_fullStr | Effect of non-surgical periodontal therapy on salivary and gingival crevicular fluid concentration of visfatin in periodontal health and disease |
| title_full_unstemmed | Effect of non-surgical periodontal therapy on salivary and gingival crevicular fluid concentration of visfatin in periodontal health and disease |
| title_short | Effect of non-surgical periodontal therapy on salivary and gingival crevicular fluid concentration of visfatin in periodontal health and disease |
| title_sort | effect of non surgical periodontal therapy on salivary and gingival crevicular fluid concentration of visfatin in periodontal health and disease |
| topic | Visfatin Periodontitis Saliva Gingival crevicular fluid Non-surgical periodontal therapy Scaling and root planing |
| url | http://www.sciencedirect.com/science/article/pii/S2212426824000666 |
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