Palmitic Acid Accelerates Endothelial Cell Injury and Cardiovascular Dysfunction via Palmitoylation of PKM2

Palmitic Acid Accelerates Endothelial Cell Injury and Cardiovascular Dysfunction via Palmitoylation of PKM2

Abstract High serum level of palmitic acid(PA) is implicated in pathogenesis of cardiovascular diseases. PA serves as the substrate for protein palmitoylation. However, it is still unknown whether palmitoylation is involved in PA‐induced cardiovascular dysfunction. Here, in clinical cohort studies o...

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Bibliographic Details
Main Authors: Yu He, Senlin Li, Lujing Jiang, Kejue Wu, Shanshan Chen, Linjie Su, Cui Liu, Peiqing Liu, Wenwei Luo, Shilong Zhong, Zhuoming Li
Format: Article
Language:English
Published: Wiley 2025-02-01
Series:Advanced Science
Subjects:
cardiovascular dysfunction
endothelial injury
palmitic acid
palmitoylation
PKM2
Online Access:https://doi.org/10.1002/advs.202412895
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