A Randomized Trial of Ionic Silver Dressing to Reduce Surgical Site Infection After Gastrointestinal Surgery
Objective:. To determine whether Aquacel Ag Hydrofiber dressings containing ionic silver are superior to film dressings for preventing superficial surgical site infections (SSI) in patients undergoing elective gastrointestinal surgery. Background:. Multiple clinical trials have assessed the effectiv...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Health
2024-03-01
|
| Series: | Annals of Surgery Open |
| Online Access: | http://journals.lww.com/10.1097/AS9.0000000000000402 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832589692197928960 |
|---|---|
| author | Chihiro Kosugi, MD Keiji Koda, MD Hiroaki Shimizu, MD Masato Yamazaki, MD Kiyohiko Shuto, MD Mikito Mori, MD Akihiro Usui, MD Hiroyuki Nojima, MD Satoshi Endo, MD Hiroo Yanagibashi, MD Hidehito Arimitsu, MD Toru Tochigi, MD Tetsutaro Sazuka, MD Mihono Hirota, MD Hideyuki Kuboki, MD |
| author_facet | Chihiro Kosugi, MD Keiji Koda, MD Hiroaki Shimizu, MD Masato Yamazaki, MD Kiyohiko Shuto, MD Mikito Mori, MD Akihiro Usui, MD Hiroyuki Nojima, MD Satoshi Endo, MD Hiroo Yanagibashi, MD Hidehito Arimitsu, MD Toru Tochigi, MD Tetsutaro Sazuka, MD Mihono Hirota, MD Hideyuki Kuboki, MD |
| author_sort | Chihiro Kosugi, MD |
| collection | DOAJ |
| description | Objective:. To determine whether Aquacel Ag Hydrofiber dressings containing ionic silver are superior to film dressings for preventing superficial surgical site infections (SSI) in patients undergoing elective gastrointestinal surgery.
Background:. Multiple clinical trials have assessed the effectiveness of silver-containing wound dressings; however, systematic reviews failed to find any advantages of these dressings and concluded that there was insufficient evidence to indicate that they prevented wound infections. This study aimed to evaluate the efficacy of Aquacel Ag Hydrofiber dressings for preventing superficial SSIs in patients undergoing gastrointestinal surgery.
Methods:. Patients undergoing elective gastrointestinal surgery were randomly assigned to receive either Aquacel Ag Hydrofiber (study group) or film dressings (control group). The primary end point was superficial SSI within 30 days after surgery (UMIN Clinical Trials Registry ID: 000043081).
Results:. A total of 865 patients (427 study group, 438 control group) were qualified for primary end-point analysis. The overall rate of superficial SSIs was significantly lower in the study group than in the control group (6.8% vs 11.4%, P = 0.019). There was no significant difference in superficial SSI rates between the groups in patients undergoing upper gastrointestinal surgery; however, the rate was significantly lower in the study group in patients undergoing lower gastrointestinal surgery (P = 0.042). Multivariate analysis identified Aquacel Ag Hydrofiber dressings as an independent factor for reducing superficial SSIs (odds ratio, 0.602; 95% confidence interval, 0.367–0.986; P = 0.044).
Conclusions:. Aquacel Ag Hydrofiber dressings can reduce superficial SSIs compared to film dressings in patients undergoing elective gastrointestinal surgery, especially lower gastrointestinal surgery. |
| format | Article |
| id | doaj-art-46198aebdee744b58b03a8ff51f6fc2c |
| institution | Kabale University |
| issn | 2691-3593 |
| language | English |
| publishDate | 2024-03-01 |
| publisher | Wolters Kluwer Health |
| record_format | Article |
| series | Annals of Surgery Open |
| spelling | doaj-art-46198aebdee744b58b03a8ff51f6fc2c2025-01-24T09:18:25ZengWolters Kluwer HealthAnnals of Surgery Open2691-35932024-03-0151e40210.1097/AS9.0000000000000402202403000-00034A Randomized Trial of Ionic Silver Dressing to Reduce Surgical Site Infection After Gastrointestinal SurgeryChihiro Kosugi, MD0Keiji Koda, MD1Hiroaki Shimizu, MD2Masato Yamazaki, MD3Kiyohiko Shuto, MD4Mikito Mori, MD5Akihiro Usui, MD6Hiroyuki Nojima, MD7Satoshi Endo, MD8Hiroo Yanagibashi, MD9Hidehito Arimitsu, MD10Toru Tochigi, MD11Tetsutaro Sazuka, MD12Mihono Hirota, MD13Hideyuki Kuboki, MD14* From the Department of Surgery, Teikyo University Chiba Medical Center, Ichihara, Chiba, Japan.* From the Department of Surgery, Teikyo University Chiba Medical Center, Ichihara, Chiba, Japan.* From the Department of Surgery, Teikyo University Chiba Medical Center, Ichihara, Chiba, Japan.* From the Department of Surgery, Teikyo University Chiba Medical Center, Ichihara, Chiba, Japan.* From the Department of Surgery, Teikyo University Chiba Medical Center, Ichihara, Chiba, Japan.* From the Department of Surgery, Teikyo University Chiba Medical Center, Ichihara, Chiba, Japan.* From the Department of Surgery, Teikyo University Chiba Medical Center, Ichihara, Chiba, Japan.* From the Department of Surgery, Teikyo University Chiba Medical Center, Ichihara, Chiba, Japan.* From the Department of Surgery, Teikyo University Chiba Medical Center, Ichihara, Chiba, Japan.* From the Department of Surgery, Teikyo University Chiba Medical Center, Ichihara, Chiba, Japan.* From the Department of Surgery, Teikyo University Chiba Medical Center, Ichihara, Chiba, Japan.* From the Department of Surgery, Teikyo University Chiba Medical Center, Ichihara, Chiba, Japan.* From the Department of Surgery, Teikyo University Chiba Medical Center, Ichihara, Chiba, Japan.* From the Department of Surgery, Teikyo University Chiba Medical Center, Ichihara, Chiba, Japan.* From the Department of Surgery, Teikyo University Chiba Medical Center, Ichihara, Chiba, Japan.Objective:. To determine whether Aquacel Ag Hydrofiber dressings containing ionic silver are superior to film dressings for preventing superficial surgical site infections (SSI) in patients undergoing elective gastrointestinal surgery. Background:. Multiple clinical trials have assessed the effectiveness of silver-containing wound dressings; however, systematic reviews failed to find any advantages of these dressings and concluded that there was insufficient evidence to indicate that they prevented wound infections. This study aimed to evaluate the efficacy of Aquacel Ag Hydrofiber dressings for preventing superficial SSIs in patients undergoing gastrointestinal surgery. Methods:. Patients undergoing elective gastrointestinal surgery were randomly assigned to receive either Aquacel Ag Hydrofiber (study group) or film dressings (control group). The primary end point was superficial SSI within 30 days after surgery (UMIN Clinical Trials Registry ID: 000043081). Results:. A total of 865 patients (427 study group, 438 control group) were qualified for primary end-point analysis. The overall rate of superficial SSIs was significantly lower in the study group than in the control group (6.8% vs 11.4%, P = 0.019). There was no significant difference in superficial SSI rates between the groups in patients undergoing upper gastrointestinal surgery; however, the rate was significantly lower in the study group in patients undergoing lower gastrointestinal surgery (P = 0.042). Multivariate analysis identified Aquacel Ag Hydrofiber dressings as an independent factor for reducing superficial SSIs (odds ratio, 0.602; 95% confidence interval, 0.367–0.986; P = 0.044). Conclusions:. Aquacel Ag Hydrofiber dressings can reduce superficial SSIs compared to film dressings in patients undergoing elective gastrointestinal surgery, especially lower gastrointestinal surgery.http://journals.lww.com/10.1097/AS9.0000000000000402 |
| spellingShingle | Chihiro Kosugi, MD Keiji Koda, MD Hiroaki Shimizu, MD Masato Yamazaki, MD Kiyohiko Shuto, MD Mikito Mori, MD Akihiro Usui, MD Hiroyuki Nojima, MD Satoshi Endo, MD Hiroo Yanagibashi, MD Hidehito Arimitsu, MD Toru Tochigi, MD Tetsutaro Sazuka, MD Mihono Hirota, MD Hideyuki Kuboki, MD A Randomized Trial of Ionic Silver Dressing to Reduce Surgical Site Infection After Gastrointestinal Surgery Annals of Surgery Open |
| title | A Randomized Trial of Ionic Silver Dressing to Reduce Surgical Site Infection After Gastrointestinal Surgery |
| title_full | A Randomized Trial of Ionic Silver Dressing to Reduce Surgical Site Infection After Gastrointestinal Surgery |
| title_fullStr | A Randomized Trial of Ionic Silver Dressing to Reduce Surgical Site Infection After Gastrointestinal Surgery |
| title_full_unstemmed | A Randomized Trial of Ionic Silver Dressing to Reduce Surgical Site Infection After Gastrointestinal Surgery |
| title_short | A Randomized Trial of Ionic Silver Dressing to Reduce Surgical Site Infection After Gastrointestinal Surgery |
| title_sort | randomized trial of ionic silver dressing to reduce surgical site infection after gastrointestinal surgery |
| url | http://journals.lww.com/10.1097/AS9.0000000000000402 |
| work_keys_str_mv | AT chihirokosugimd arandomizedtrialofionicsilverdressingtoreducesurgicalsiteinfectionaftergastrointestinalsurgery AT keijikodamd arandomizedtrialofionicsilverdressingtoreducesurgicalsiteinfectionaftergastrointestinalsurgery AT hiroakishimizumd arandomizedtrialofionicsilverdressingtoreducesurgicalsiteinfectionaftergastrointestinalsurgery AT masatoyamazakimd arandomizedtrialofionicsilverdressingtoreducesurgicalsiteinfectionaftergastrointestinalsurgery AT kiyohikoshutomd arandomizedtrialofionicsilverdressingtoreducesurgicalsiteinfectionaftergastrointestinalsurgery AT mikitomorimd arandomizedtrialofionicsilverdressingtoreducesurgicalsiteinfectionaftergastrointestinalsurgery AT akihirousuimd arandomizedtrialofionicsilverdressingtoreducesurgicalsiteinfectionaftergastrointestinalsurgery AT hiroyukinojimamd arandomizedtrialofionicsilverdressingtoreducesurgicalsiteinfectionaftergastrointestinalsurgery AT satoshiendomd arandomizedtrialofionicsilverdressingtoreducesurgicalsiteinfectionaftergastrointestinalsurgery AT hirooyanagibashimd arandomizedtrialofionicsilverdressingtoreducesurgicalsiteinfectionaftergastrointestinalsurgery AT hidehitoarimitsumd arandomizedtrialofionicsilverdressingtoreducesurgicalsiteinfectionaftergastrointestinalsurgery AT torutochigimd arandomizedtrialofionicsilverdressingtoreducesurgicalsiteinfectionaftergastrointestinalsurgery AT tetsutarosazukamd arandomizedtrialofionicsilverdressingtoreducesurgicalsiteinfectionaftergastrointestinalsurgery AT mihonohirotamd arandomizedtrialofionicsilverdressingtoreducesurgicalsiteinfectionaftergastrointestinalsurgery AT hideyukikubokimd arandomizedtrialofionicsilverdressingtoreducesurgicalsiteinfectionaftergastrointestinalsurgery AT chihirokosugimd randomizedtrialofionicsilverdressingtoreducesurgicalsiteinfectionaftergastrointestinalsurgery AT keijikodamd randomizedtrialofionicsilverdressingtoreducesurgicalsiteinfectionaftergastrointestinalsurgery AT hiroakishimizumd randomizedtrialofionicsilverdressingtoreducesurgicalsiteinfectionaftergastrointestinalsurgery AT masatoyamazakimd randomizedtrialofionicsilverdressingtoreducesurgicalsiteinfectionaftergastrointestinalsurgery AT kiyohikoshutomd randomizedtrialofionicsilverdressingtoreducesurgicalsiteinfectionaftergastrointestinalsurgery AT mikitomorimd randomizedtrialofionicsilverdressingtoreducesurgicalsiteinfectionaftergastrointestinalsurgery AT akihirousuimd randomizedtrialofionicsilverdressingtoreducesurgicalsiteinfectionaftergastrointestinalsurgery AT hiroyukinojimamd randomizedtrialofionicsilverdressingtoreducesurgicalsiteinfectionaftergastrointestinalsurgery AT satoshiendomd randomizedtrialofionicsilverdressingtoreducesurgicalsiteinfectionaftergastrointestinalsurgery AT hirooyanagibashimd randomizedtrialofionicsilverdressingtoreducesurgicalsiteinfectionaftergastrointestinalsurgery AT hidehitoarimitsumd randomizedtrialofionicsilverdressingtoreducesurgicalsiteinfectionaftergastrointestinalsurgery AT torutochigimd randomizedtrialofionicsilverdressingtoreducesurgicalsiteinfectionaftergastrointestinalsurgery AT tetsutarosazukamd randomizedtrialofionicsilverdressingtoreducesurgicalsiteinfectionaftergastrointestinalsurgery AT mihonohirotamd randomizedtrialofionicsilverdressingtoreducesurgicalsiteinfectionaftergastrointestinalsurgery AT hideyukikubokimd randomizedtrialofionicsilverdressingtoreducesurgicalsiteinfectionaftergastrointestinalsurgery |