Critical appraisal and comparison of recommendations of clinical practice guidelines for the treatment of schizophrenia in children and adolescents: a methodological survey
Introduction The production of clinical practice guidelines (CPGs) has grown in the past years. Notwithstanding, the quality of these documents and their recommendations for the treatment of schizophrenia in children and adolescents is still unknown.Objective To assess the quality of the guidelines...
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BMJ Publishing Group
2023-02-01
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| author | Cristiane de Cássia Bergamaschi Silvio Barberato-Filho Luciane Cruz Lopes Nigar Sekercioglu Rejane Coan Ferretti Mayer Jardel Corrêa de Oliveira Franciele Cordeiro Gabriel Daniela Oliveira de Melo Maíra Ramos Alves Carmen Verônica Mendes Abdala |
| author_facet | Cristiane de Cássia Bergamaschi Silvio Barberato-Filho Luciane Cruz Lopes Nigar Sekercioglu Rejane Coan Ferretti Mayer Jardel Corrêa de Oliveira Franciele Cordeiro Gabriel Daniela Oliveira de Melo Maíra Ramos Alves Carmen Verônica Mendes Abdala |
| author_sort | Cristiane de Cássia Bergamaschi |
| collection | DOAJ |
| description | Introduction The production of clinical practice guidelines (CPGs) has grown in the past years. Notwithstanding, the quality of these documents and their recommendations for the treatment of schizophrenia in children and adolescents is still unknown.Objective To assess the quality of the guidelines and recommendations for the treatment of schizophrenia in this population.Methods CPGs from 2004 to December 2020 were identified through a systematic search on EMBASE, MEDLINE, PsycINFO, PubMed, Epistemonikos, VHL, Global Index Medicus and specific CPG databases. The CPGs’ quality was independently assessed by three reviewers using AGREE II and they were considered of high quality if they scored ≥60% in domains 3 and 6. The evidence classification systems were described, the quality of recommendations was assessed in pairs using AGREE-REX and the recommendations were compared.Results The database search retrieved 3182 results; 2030 were screened and 29 were selected for full-text reading. Four guidelines were selected for extraction. Two CPGs were considered of high quality in the AGREE II assessment. We described the commonly agreed recommendations for each treatment phase. The pharmacological recommendations were described in all treatment phases. Scores of AGREE-REX were lower for psychosocial recommendations.Conclusion There are still few clinical studies and CPGs regarding schizophrenia in children and adolescents. The quality of the documents was overall low, and the quality of the recommendations report has much to improve. There is also a lack of transparency about the quality of the evidence and the strength of the recommendations.Protocol registration number CRD42020164899. |
| format | Article |
| id | doaj-art-460743ee83564725aadd62454e8f9f9c |
| institution | DOAJ |
| issn | 2044-6055 |
| language | English |
| publishDate | 2023-02-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-460743ee83564725aadd62454e8f9f9c2025-08-20T03:15:26ZengBMJ Publishing GroupBMJ Open2044-60552023-02-0113210.1136/bmjopen-2022-070332Critical appraisal and comparison of recommendations of clinical practice guidelines for the treatment of schizophrenia in children and adolescents: a methodological surveyCristiane de Cássia Bergamaschi0Silvio Barberato-Filho1Luciane Cruz Lopes2Nigar Sekercioglu3Rejane Coan Ferretti Mayer4Jardel Corrêa de Oliveira5Franciele Cordeiro Gabriel6Daniela Oliveira de Melo7Maíra Ramos Alves8Carmen Verônica Mendes Abdala9Department of Pharmaceutical Sciences, Universidade de Sorocaba, Sorocaba, BrazilGraduate Course in Pharmaceutical Sciences, University of Sorocaba, Sorocaba, BrazilGraduate Course in Pharmaceutical Sciences, University of Sorocaba, Sorocaba, BrazilHealth Research Methodology, McMaster University, Mississauga, Ontario, CanadaGraduate Course in Pharmaceutical Sciences, University of Sorocaba, Sorocaba, BrazilDepartment of Pharmaceutical Sciences, University of Sorocaba, Sorocaba, BrazilDepartamento de Ciências Farmacêuticas, Universidade de Sao Paulo, Sao Paulo, SP, BrazilDepartamento de Ciências Farmacêuticas, Universidade Federal de Sao Paulo, São Paulo, BrazilGraduate Course in Pharmaceutical Sciences, University of Sorocaba, Sorocaba, BrazilPan American Health Organization, World Health Organization, São Paulo, BrazilIntroduction The production of clinical practice guidelines (CPGs) has grown in the past years. Notwithstanding, the quality of these documents and their recommendations for the treatment of schizophrenia in children and adolescents is still unknown.Objective To assess the quality of the guidelines and recommendations for the treatment of schizophrenia in this population.Methods CPGs from 2004 to December 2020 were identified through a systematic search on EMBASE, MEDLINE, PsycINFO, PubMed, Epistemonikos, VHL, Global Index Medicus and specific CPG databases. The CPGs’ quality was independently assessed by three reviewers using AGREE II and they were considered of high quality if they scored ≥60% in domains 3 and 6. The evidence classification systems were described, the quality of recommendations was assessed in pairs using AGREE-REX and the recommendations were compared.Results The database search retrieved 3182 results; 2030 were screened and 29 were selected for full-text reading. Four guidelines were selected for extraction. Two CPGs were considered of high quality in the AGREE II assessment. We described the commonly agreed recommendations for each treatment phase. The pharmacological recommendations were described in all treatment phases. Scores of AGREE-REX were lower for psychosocial recommendations.Conclusion There are still few clinical studies and CPGs regarding schizophrenia in children and adolescents. The quality of the documents was overall low, and the quality of the recommendations report has much to improve. There is also a lack of transparency about the quality of the evidence and the strength of the recommendations.Protocol registration number CRD42020164899.https://bmjopen.bmj.com/content/13/2/e070332.full |
| spellingShingle | Cristiane de Cássia Bergamaschi Silvio Barberato-Filho Luciane Cruz Lopes Nigar Sekercioglu Rejane Coan Ferretti Mayer Jardel Corrêa de Oliveira Franciele Cordeiro Gabriel Daniela Oliveira de Melo Maíra Ramos Alves Carmen Verônica Mendes Abdala Critical appraisal and comparison of recommendations of clinical practice guidelines for the treatment of schizophrenia in children and adolescents: a methodological survey BMJ Open |
| title | Critical appraisal and comparison of recommendations of clinical practice guidelines for the treatment of schizophrenia in children and adolescents: a methodological survey |
| title_full | Critical appraisal and comparison of recommendations of clinical practice guidelines for the treatment of schizophrenia in children and adolescents: a methodological survey |
| title_fullStr | Critical appraisal and comparison of recommendations of clinical practice guidelines for the treatment of schizophrenia in children and adolescents: a methodological survey |
| title_full_unstemmed | Critical appraisal and comparison of recommendations of clinical practice guidelines for the treatment of schizophrenia in children and adolescents: a methodological survey |
| title_short | Critical appraisal and comparison of recommendations of clinical practice guidelines for the treatment of schizophrenia in children and adolescents: a methodological survey |
| title_sort | critical appraisal and comparison of recommendations of clinical practice guidelines for the treatment of schizophrenia in children and adolescents a methodological survey |
| url | https://bmjopen.bmj.com/content/13/2/e070332.full |
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