Mathematical Modelling of Acetaminophen Release in HPC/PAAm Hydrogel: Synthesis and Application
Hydrogels are commonly used as Drug Delivery Systems (DDS) as patches due to its ability to store drug molecules within their structures. The release can be activated under certain stimuli, such as temperature and pH. In this paper, the mathematical modelling of acetaminophen release in hydroxypropy...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | International Journal of Polymer Science |
| Online Access: | http://dx.doi.org/10.1155/2019/9306459 |
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| author | Abigail M. Díaz-Guerrero Claudia A. Castillo-Miranda Carlos F. Castro-Guerrero Hernán Peraza-Vázquez Ana B. Morales-Cepeda Adrián F. Peña-Delgado |
| author_facet | Abigail M. Díaz-Guerrero Claudia A. Castillo-Miranda Carlos F. Castro-Guerrero Hernán Peraza-Vázquez Ana B. Morales-Cepeda Adrián F. Peña-Delgado |
| author_sort | Abigail M. Díaz-Guerrero |
| collection | DOAJ |
| description | Hydrogels are commonly used as Drug Delivery Systems (DDS) as patches due to its ability to store drug molecules within their structures. The release can be activated under certain stimuli, such as temperature and pH. In this paper, the mathematical modelling of acetaminophen release in hydroxypropyl cellulose with polyacrylamide (HPC/PAAm) is reported. The HPC/PAAm gel was synthesized in proportions of 25/75 wt% and was characterized by FTIR, DSC, optical microscopy, SEM, and TGA, with and without acetaminophen. The release tests were performed for hypothermic, normal, and febrile human body conditions, at 35, 37, and 39°C, respectively, on two release media: water and phosphate buffer solution. In order to describe the release of acetaminophen in HPC/PAAm gel, a genetic programming algorithm was used to accomplish Multigene Symbolic Regression (MSR). Characterization results showed that the drug was crystallized on the surface of the HPC/PAAm gel. Release test results showed that several simultaneous processes occurred in the acetaminophen diffusion phenomenon. A unique mathematical model was obtained by MSR. This model was able to describe the release of acetaminophen in HPC/PAAm gel with high values of R2 and adjusted R2 and to simulate the drug release at times beyond the end of the experiment. High values of R2 and low values of Coefficient of Variation (CV), Root-Mean-Square Error (RMSE), and Mean Absolute Error (MAE) were obtained from the comparison between the simulated and the experimental data. This allows to conclude that the mathematical model is reliable to represent and simulate the acetaminophen release in HPC/PAAm gel at 35, 37, and 39°C. |
| format | Article |
| id | doaj-art-45e89ed5044548caa5028a1ad64a30d1 |
| institution | Kabale University |
| issn | 1687-9422 1687-9430 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Polymer Science |
| spelling | doaj-art-45e89ed5044548caa5028a1ad64a30d12025-02-03T01:32:38ZengWileyInternational Journal of Polymer Science1687-94221687-94302019-01-01201910.1155/2019/93064599306459Mathematical Modelling of Acetaminophen Release in HPC/PAAm Hydrogel: Synthesis and ApplicationAbigail M. Díaz-Guerrero0Claudia A. Castillo-Miranda1Carlos F. Castro-Guerrero2Hernán Peraza-Vázquez3Ana B. Morales-Cepeda4Adrián F. Peña-Delgado5Instituto Politécnico Nacional, Centro de Investigación en Ciencia Aplicada y Tecnología Aplicada (CICATA) Unidad Altamira, Carretera Tampico-Puerto Industrial de Altamira, Km 14.5, Altamira C.P. 89600, MexicoTecnológico Nacional de México/Instituto Tecnológico de Ciudad Madero, Centro de Investigación en Petroquímica, Parque Industrial Tecnia, Altamira C.P. 89603, MexicoCONACyT-Instituto Nacional de Electricidad y Energías Limpias, Departamento de Sistemas Mecánicos, Reforma 113, Cuernavaca C.P. 62490, MexicoInstituto Politécnico Nacional, Centro de Investigación en Ciencia Aplicada y Tecnología Aplicada (CICATA) Unidad Altamira, Carretera Tampico-Puerto Industrial de Altamira, Km 14.5, Altamira C.P. 89600, MexicoTecnológico Nacional de México/Instituto Tecnológico de Ciudad Madero, Centro de Investigación en Petroquímica, Parque Industrial Tecnia, Altamira C.P. 89603, MexicoUniversidad Politécnica de Altamira, Nuevo Libramiento Altamira KM 3, Altamira/C.P. 89602, MexicoHydrogels are commonly used as Drug Delivery Systems (DDS) as patches due to its ability to store drug molecules within their structures. The release can be activated under certain stimuli, such as temperature and pH. In this paper, the mathematical modelling of acetaminophen release in hydroxypropyl cellulose with polyacrylamide (HPC/PAAm) is reported. The HPC/PAAm gel was synthesized in proportions of 25/75 wt% and was characterized by FTIR, DSC, optical microscopy, SEM, and TGA, with and without acetaminophen. The release tests were performed for hypothermic, normal, and febrile human body conditions, at 35, 37, and 39°C, respectively, on two release media: water and phosphate buffer solution. In order to describe the release of acetaminophen in HPC/PAAm gel, a genetic programming algorithm was used to accomplish Multigene Symbolic Regression (MSR). Characterization results showed that the drug was crystallized on the surface of the HPC/PAAm gel. Release test results showed that several simultaneous processes occurred in the acetaminophen diffusion phenomenon. A unique mathematical model was obtained by MSR. This model was able to describe the release of acetaminophen in HPC/PAAm gel with high values of R2 and adjusted R2 and to simulate the drug release at times beyond the end of the experiment. High values of R2 and low values of Coefficient of Variation (CV), Root-Mean-Square Error (RMSE), and Mean Absolute Error (MAE) were obtained from the comparison between the simulated and the experimental data. This allows to conclude that the mathematical model is reliable to represent and simulate the acetaminophen release in HPC/PAAm gel at 35, 37, and 39°C.http://dx.doi.org/10.1155/2019/9306459 |
| spellingShingle | Abigail M. Díaz-Guerrero Claudia A. Castillo-Miranda Carlos F. Castro-Guerrero Hernán Peraza-Vázquez Ana B. Morales-Cepeda Adrián F. Peña-Delgado Mathematical Modelling of Acetaminophen Release in HPC/PAAm Hydrogel: Synthesis and Application International Journal of Polymer Science |
| title | Mathematical Modelling of Acetaminophen Release in HPC/PAAm Hydrogel: Synthesis and Application |
| title_full | Mathematical Modelling of Acetaminophen Release in HPC/PAAm Hydrogel: Synthesis and Application |
| title_fullStr | Mathematical Modelling of Acetaminophen Release in HPC/PAAm Hydrogel: Synthesis and Application |
| title_full_unstemmed | Mathematical Modelling of Acetaminophen Release in HPC/PAAm Hydrogel: Synthesis and Application |
| title_short | Mathematical Modelling of Acetaminophen Release in HPC/PAAm Hydrogel: Synthesis and Application |
| title_sort | mathematical modelling of acetaminophen release in hpc paam hydrogel synthesis and application |
| url | http://dx.doi.org/10.1155/2019/9306459 |
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