Vaginal Microbiota and the Use of Probiotics
The human vagina is inhabited by a range of microbes from a pool of over 50 species. Lactobacilli are the most common, particularly in healthy women. The microbiota can change composition rapidly, for reasons that are not fully clear. This can lead to infection or to a state in which organisms with...
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| Format: | Article |
| Language: | English |
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Wiley
2008-01-01
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| Series: | Interdisciplinary Perspectives on Infectious Diseases |
| Online Access: | http://dx.doi.org/10.1155/2008/256490 |
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| author | Sarah Cribby Michelle Taylor Gregor Reid |
| author_facet | Sarah Cribby Michelle Taylor Gregor Reid |
| author_sort | Sarah Cribby |
| collection | DOAJ |
| description | The human vagina is inhabited by a range of microbes from a pool of over 50 species. Lactobacilli are the most common, particularly in healthy women. The microbiota can change composition rapidly, for reasons that are not fully clear. This can lead to infection or to a state in which organisms with pathogenic potential coexist with other commensals. The most common urogenital infection in premenopausal women is bacterial vaginosis (BV), a condition characterized by a depletion of lactobacilli population and the presence of Gram-negative anaerobes, or in some cases Gram-positive cocci, and aerobic pathogens. Treatment of BV traditionally involves the antibiotics metronidazole or clindamycin, however, the recurrence rate remains high, and this treatment is not designed to restore the lactobacilli. In vitro studies have shown that Lactobacillus strains can disrupt BV and yeast biofilms and inhibit the growth of urogenital pathogens. The use of probiotics to populate the vagina and prevent or treat infection has been considered for some time, but only quite recently have data emerged to show efficacy, including supplementation of antimicrobial treatment to improve cure rates and prevent recurrences. |
| format | Article |
| id | doaj-art-45e50c68852d4e44bea51beec24475c0 |
| institution | Kabale University |
| issn | 1687-708X 1687-7098 |
| language | English |
| publishDate | 2008-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Interdisciplinary Perspectives on Infectious Diseases |
| spelling | doaj-art-45e50c68852d4e44bea51beec24475c02025-02-03T05:53:44ZengWileyInterdisciplinary Perspectives on Infectious Diseases1687-708X1687-70982008-01-01200810.1155/2008/256490256490Vaginal Microbiota and the Use of ProbioticsSarah Cribby0Michelle Taylor1Gregor Reid2Canadian Research and Development Centre for Probiotics, Lawson Health Research Institute, 268 Grosvenor Street, London, ON, N6A 4V2, CanadaCanadian Research and Development Centre for Probiotics, Lawson Health Research Institute, 268 Grosvenor Street, London, ON, N6A 4V2, CanadaCanadian Research and Development Centre for Probiotics, Lawson Health Research Institute, 268 Grosvenor Street, London, ON, N6A 4V2, CanadaThe human vagina is inhabited by a range of microbes from a pool of over 50 species. Lactobacilli are the most common, particularly in healthy women. The microbiota can change composition rapidly, for reasons that are not fully clear. This can lead to infection or to a state in which organisms with pathogenic potential coexist with other commensals. The most common urogenital infection in premenopausal women is bacterial vaginosis (BV), a condition characterized by a depletion of lactobacilli population and the presence of Gram-negative anaerobes, or in some cases Gram-positive cocci, and aerobic pathogens. Treatment of BV traditionally involves the antibiotics metronidazole or clindamycin, however, the recurrence rate remains high, and this treatment is not designed to restore the lactobacilli. In vitro studies have shown that Lactobacillus strains can disrupt BV and yeast biofilms and inhibit the growth of urogenital pathogens. The use of probiotics to populate the vagina and prevent or treat infection has been considered for some time, but only quite recently have data emerged to show efficacy, including supplementation of antimicrobial treatment to improve cure rates and prevent recurrences.http://dx.doi.org/10.1155/2008/256490 |
| spellingShingle | Sarah Cribby Michelle Taylor Gregor Reid Vaginal Microbiota and the Use of Probiotics Interdisciplinary Perspectives on Infectious Diseases |
| title | Vaginal Microbiota and the Use of Probiotics |
| title_full | Vaginal Microbiota and the Use of Probiotics |
| title_fullStr | Vaginal Microbiota and the Use of Probiotics |
| title_full_unstemmed | Vaginal Microbiota and the Use of Probiotics |
| title_short | Vaginal Microbiota and the Use of Probiotics |
| title_sort | vaginal microbiota and the use of probiotics |
| url | http://dx.doi.org/10.1155/2008/256490 |
| work_keys_str_mv | AT sarahcribby vaginalmicrobiotaandtheuseofprobiotics AT michelletaylor vaginalmicrobiotaandtheuseofprobiotics AT gregorreid vaginalmicrobiotaandtheuseofprobiotics |