Characteristics of Optic Neuritis in South Korean Children and Adolescents: A Retrospective Multicenter Study
Purpose. To analyze the clinical characteristics and prognosis of optic neuritis (ON) in pediatric patients aged <19 years in South Korea. Methods. This multicenter retrospective cohort study included 127 pediatric patients (median age: 10.3 (IQR: 7.3–14.2) years; female, 62.2%) who experienced O...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-01-01
|
| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2022/4281772 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832548811576180736 |
|---|---|
| author | Kyung-Ah Park Hee Kyung Yang Jinu Han Seong-Joon Kim Sung Eun Park Haeng-Jin Lee Sueng-Han Han Sei Yeul Oh Jeong-Min Hwang |
| author_facet | Kyung-Ah Park Hee Kyung Yang Jinu Han Seong-Joon Kim Sung Eun Park Haeng-Jin Lee Sueng-Han Han Sei Yeul Oh Jeong-Min Hwang |
| author_sort | Kyung-Ah Park |
| collection | DOAJ |
| description | Purpose. To analyze the clinical characteristics and prognosis of optic neuritis (ON) in pediatric patients aged <19 years in South Korea. Methods. This multicenter retrospective cohort study included 127 pediatric patients (median age: 10.3 (IQR: 7.3–14.2) years; female, 62.2%) who experienced ON for the first time between January 2004 and January 2018, with data obtained from five tertiary university-based hospitals in Korea. When ON was bilateral, the worse eye was selected for analysis. The baseline clinical characteristics and prognoses of patients, as well as the associations between these parameters, were analyzed. Results. The baseline clinical characteristics of the patients were as follows: best-corrected visual acuity (BCVA) < 20/200, 65.9%; pain on eye movement, 47.2%; optic disc swelling, 66.9%; and bilateral involvement, 41.7%. Among 101 patients who were followed up for ≥6 months, 48 (47.5%), 12 (11.9%), 19 (18.8%), 13 (12.9%), and 9 (8.9%) had been diagnosed with isolated ON, recurrent ON, multiple sclerosis (MS), neuromyelitis optica spectrum disorder (NMOSD), and acute disseminated encephalomyelitis (ADEM)-related ON, respectively. At the latest visit, 81.9% and 71.1% had achieved BCVA of ≥20/40 and ≥ 20/25, respectively. Only disc swelling at presentation was associated with poor baseline BCVA (coefficient: 0.31, P=0.004) and greater improvement in BCVA (coefficient: 0.49, P = 0.001P=0.001); there were no significant associations between the baseline factors and final BCVA. Conclusions. This study demonstrated pediatric ON-related clinical characteristics and visual outcomes in South Korea. Within this cohort, in about 40.6% of patients, ON was associated with other demyelinating diseases, namely, MS, NMOSD, and ADEM. |
| format | Article |
| id | doaj-art-45cbaea6e1674563ad3f895de6b8861b |
| institution | Kabale University |
| issn | 2090-0058 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-45cbaea6e1674563ad3f895de6b8861b2025-02-03T06:12:57ZengWileyJournal of Ophthalmology2090-00582022-01-01202210.1155/2022/4281772Characteristics of Optic Neuritis in South Korean Children and Adolescents: A Retrospective Multicenter StudyKyung-Ah Park0Hee Kyung Yang1Jinu Han2Seong-Joon Kim3Sung Eun Park4Haeng-Jin Lee5Sueng-Han Han6Sei Yeul Oh7Jeong-Min Hwang8Department of OphthalmologyDepartment of OphthalmologyInstitute of Vision ResearchDepartment of OphthalmologyInstitute of Vision ResearchDepartment of OphthalmologyInstitute of Vision ResearchDepartment of OphthalmologyDepartment of OphthalmologyPurpose. To analyze the clinical characteristics and prognosis of optic neuritis (ON) in pediatric patients aged <19 years in South Korea. Methods. This multicenter retrospective cohort study included 127 pediatric patients (median age: 10.3 (IQR: 7.3–14.2) years; female, 62.2%) who experienced ON for the first time between January 2004 and January 2018, with data obtained from five tertiary university-based hospitals in Korea. When ON was bilateral, the worse eye was selected for analysis. The baseline clinical characteristics and prognoses of patients, as well as the associations between these parameters, were analyzed. Results. The baseline clinical characteristics of the patients were as follows: best-corrected visual acuity (BCVA) < 20/200, 65.9%; pain on eye movement, 47.2%; optic disc swelling, 66.9%; and bilateral involvement, 41.7%. Among 101 patients who were followed up for ≥6 months, 48 (47.5%), 12 (11.9%), 19 (18.8%), 13 (12.9%), and 9 (8.9%) had been diagnosed with isolated ON, recurrent ON, multiple sclerosis (MS), neuromyelitis optica spectrum disorder (NMOSD), and acute disseminated encephalomyelitis (ADEM)-related ON, respectively. At the latest visit, 81.9% and 71.1% had achieved BCVA of ≥20/40 and ≥ 20/25, respectively. Only disc swelling at presentation was associated with poor baseline BCVA (coefficient: 0.31, P=0.004) and greater improvement in BCVA (coefficient: 0.49, P = 0.001P=0.001); there were no significant associations between the baseline factors and final BCVA. Conclusions. This study demonstrated pediatric ON-related clinical characteristics and visual outcomes in South Korea. Within this cohort, in about 40.6% of patients, ON was associated with other demyelinating diseases, namely, MS, NMOSD, and ADEM.http://dx.doi.org/10.1155/2022/4281772 |
| spellingShingle | Kyung-Ah Park Hee Kyung Yang Jinu Han Seong-Joon Kim Sung Eun Park Haeng-Jin Lee Sueng-Han Han Sei Yeul Oh Jeong-Min Hwang Characteristics of Optic Neuritis in South Korean Children and Adolescents: A Retrospective Multicenter Study Journal of Ophthalmology |
| title | Characteristics of Optic Neuritis in South Korean Children and Adolescents: A Retrospective Multicenter Study |
| title_full | Characteristics of Optic Neuritis in South Korean Children and Adolescents: A Retrospective Multicenter Study |
| title_fullStr | Characteristics of Optic Neuritis in South Korean Children and Adolescents: A Retrospective Multicenter Study |
| title_full_unstemmed | Characteristics of Optic Neuritis in South Korean Children and Adolescents: A Retrospective Multicenter Study |
| title_short | Characteristics of Optic Neuritis in South Korean Children and Adolescents: A Retrospective Multicenter Study |
| title_sort | characteristics of optic neuritis in south korean children and adolescents a retrospective multicenter study |
| url | http://dx.doi.org/10.1155/2022/4281772 |
| work_keys_str_mv | AT kyungahpark characteristicsofopticneuritisinsouthkoreanchildrenandadolescentsaretrospectivemulticenterstudy AT heekyungyang characteristicsofopticneuritisinsouthkoreanchildrenandadolescentsaretrospectivemulticenterstudy AT jinuhan characteristicsofopticneuritisinsouthkoreanchildrenandadolescentsaretrospectivemulticenterstudy AT seongjoonkim characteristicsofopticneuritisinsouthkoreanchildrenandadolescentsaretrospectivemulticenterstudy AT sungeunpark characteristicsofopticneuritisinsouthkoreanchildrenandadolescentsaretrospectivemulticenterstudy AT haengjinlee characteristicsofopticneuritisinsouthkoreanchildrenandadolescentsaretrospectivemulticenterstudy AT suenghanhan characteristicsofopticneuritisinsouthkoreanchildrenandadolescentsaretrospectivemulticenterstudy AT seiyeuloh characteristicsofopticneuritisinsouthkoreanchildrenandadolescentsaretrospectivemulticenterstudy AT jeongminhwang characteristicsofopticneuritisinsouthkoreanchildrenandadolescentsaretrospectivemulticenterstudy |