Alopecia patterns and trichoscopic findings in patients with autosomal recessive congenital ichthyosis
Background:. Autosomal recessive congenital ichthyosis (ARCI) is a rare genodermatosis categorized among nonsyndromic ichthyoses. While ARCI patients often manifest hair abnormalities, their impact on the quality of life remains underreported in the literature. Objective:. This study aims to compreh...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer
2024-10-01
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| Series: | International Journal of Women's Dermatology |
| Online Access: | http://journals.lww.com/10.1097/JW9.0000000000000175 |
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| author | Anissa Zaouak, MD Wafa Jouini, MD Ghaith Abdessalem, PhD Sonia Abdelhak, PhD Houda Hammami, MD Cherine Charfeddine, PhD Samy Fenniche, MD |
| author_facet | Anissa Zaouak, MD Wafa Jouini, MD Ghaith Abdessalem, PhD Sonia Abdelhak, PhD Houda Hammami, MD Cherine Charfeddine, PhD Samy Fenniche, MD |
| author_sort | Anissa Zaouak, MD |
| collection | DOAJ |
| description | Background:. Autosomal recessive congenital ichthyosis (ARCI) is a rare genodermatosis categorized among nonsyndromic ichthyoses. While ARCI patients often manifest hair abnormalities, their impact on the quality of life remains underreported in the literature.
Objective:. This study aims to comprehensively characterize the clinical and trichoscopic findings of alopecia in ARCI patients.
Methods:. A prospective study spanning from January 2019 to December 2021 (3 years) was conducted at the Dermatology Department of Habib Thameur Hospital, Tunis, Tunisia. Clinical and trichoscopic examinations were performed on the hair of the participants, with molecular studies conducted on 15 patients.
Results:. The study included 30 patients, predominantly female (male/female = 0.58), with a mean age of 20 years. Twenty-eight patients were born from consanguineous marriages. Lamellar ichthyosis was observed in 22 cases, while congenital ichthyosiform erythroderma and bathing suit ichthyosis were each present in 4 cases. The ARCI severity score, assessed using the Visual Index For Ichthyosis Severity scale, had a mean value of 15 (4–28). Alopecia emerged as a prominent finding in 11 patients, presenting as hairline recession (13%), multiple patchy alopecia (27%), and alopecia of the eyebrows (13%). Trichoscopic findings included interfollicular and perifollicular scaling, perifollicular lamellar hyperkeratosis, peripilar casts, interfollicular erythema, loss of hair openings, predominance of single hair follicles, broken hair, vellus hair, anisotrichosis, pili torti, dystrophic hair, and comma hair. Several trichoscopic findings showed statistically significant associations with the severity of ARCI.
Limitations:. In our study, we only included 30 patients due to the rarity of this genodermatosis.
Conclusion:. Contrary to previous perceptions, alopecia is a notable finding in ARCI, particularly in patients with a severe form. This study provides a detailed characterization of alopecia in ARCI, shedding light on its prevalence and associated trichoscopic features, thereby enhancing our understanding of this dermatological condition. |
| format | Article |
| id | doaj-art-45c573ed0f264b51b6b7cc574b3e5234 |
| institution | OA Journals |
| issn | 2352-6475 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Wolters Kluwer |
| record_format | Article |
| series | International Journal of Women's Dermatology |
| spelling | doaj-art-45c573ed0f264b51b6b7cc574b3e52342025-08-20T02:18:01ZengWolters KluwerInternational Journal of Women's Dermatology2352-64752024-10-01103e17510.1097/JW9.0000000000000175202410000-00014Alopecia patterns and trichoscopic findings in patients with autosomal recessive congenital ichthyosisAnissa Zaouak, MD0Wafa Jouini, MD1Ghaith Abdessalem, PhD2Sonia Abdelhak, PhD3Houda Hammami, MD4Cherine Charfeddine, PhD5Samy Fenniche, MD6a Dermatology Department, Habib Thameur Hospital, Tunis, Tunisiaa Dermatology Department, Habib Thameur Hospital, Tunis, Tunisiab Biomedical Genomics and Oncogenetics Laboratory, Institut Pasteur de Tunis, Tunis, Tunisiab Biomedical Genomics and Oncogenetics Laboratory, Institut Pasteur de Tunis, Tunis, Tunisiaa Dermatology Department, Habib Thameur Hospital, Tunis, Tunisiab Biomedical Genomics and Oncogenetics Laboratory, Institut Pasteur de Tunis, Tunis, Tunisiaa Dermatology Department, Habib Thameur Hospital, Tunis, TunisiaBackground:. Autosomal recessive congenital ichthyosis (ARCI) is a rare genodermatosis categorized among nonsyndromic ichthyoses. While ARCI patients often manifest hair abnormalities, their impact on the quality of life remains underreported in the literature. Objective:. This study aims to comprehensively characterize the clinical and trichoscopic findings of alopecia in ARCI patients. Methods:. A prospective study spanning from January 2019 to December 2021 (3 years) was conducted at the Dermatology Department of Habib Thameur Hospital, Tunis, Tunisia. Clinical and trichoscopic examinations were performed on the hair of the participants, with molecular studies conducted on 15 patients. Results:. The study included 30 patients, predominantly female (male/female = 0.58), with a mean age of 20 years. Twenty-eight patients were born from consanguineous marriages. Lamellar ichthyosis was observed in 22 cases, while congenital ichthyosiform erythroderma and bathing suit ichthyosis were each present in 4 cases. The ARCI severity score, assessed using the Visual Index For Ichthyosis Severity scale, had a mean value of 15 (4–28). Alopecia emerged as a prominent finding in 11 patients, presenting as hairline recession (13%), multiple patchy alopecia (27%), and alopecia of the eyebrows (13%). Trichoscopic findings included interfollicular and perifollicular scaling, perifollicular lamellar hyperkeratosis, peripilar casts, interfollicular erythema, loss of hair openings, predominance of single hair follicles, broken hair, vellus hair, anisotrichosis, pili torti, dystrophic hair, and comma hair. Several trichoscopic findings showed statistically significant associations with the severity of ARCI. Limitations:. In our study, we only included 30 patients due to the rarity of this genodermatosis. Conclusion:. Contrary to previous perceptions, alopecia is a notable finding in ARCI, particularly in patients with a severe form. This study provides a detailed characterization of alopecia in ARCI, shedding light on its prevalence and associated trichoscopic features, thereby enhancing our understanding of this dermatological condition.http://journals.lww.com/10.1097/JW9.0000000000000175 |
| spellingShingle | Anissa Zaouak, MD Wafa Jouini, MD Ghaith Abdessalem, PhD Sonia Abdelhak, PhD Houda Hammami, MD Cherine Charfeddine, PhD Samy Fenniche, MD Alopecia patterns and trichoscopic findings in patients with autosomal recessive congenital ichthyosis International Journal of Women's Dermatology |
| title | Alopecia patterns and trichoscopic findings in patients with autosomal recessive congenital ichthyosis |
| title_full | Alopecia patterns and trichoscopic findings in patients with autosomal recessive congenital ichthyosis |
| title_fullStr | Alopecia patterns and trichoscopic findings in patients with autosomal recessive congenital ichthyosis |
| title_full_unstemmed | Alopecia patterns and trichoscopic findings in patients with autosomal recessive congenital ichthyosis |
| title_short | Alopecia patterns and trichoscopic findings in patients with autosomal recessive congenital ichthyosis |
| title_sort | alopecia patterns and trichoscopic findings in patients with autosomal recessive congenital ichthyosis |
| url | http://journals.lww.com/10.1097/JW9.0000000000000175 |
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