NK cell activity in the tumor microenvironment

NK cell activity in the tumor microenvironment

The formation of an immunosuppressive tumor microenvironment (TME) impairs natural killer (NK) cell infiltration and persistence within tumor tissue and significantly diminishes NK-mediated cytotoxicity. This presents a substantial barrier to the efficacy of NK cell therapy in solid tumors. Current...

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Bibliographic Details
Main Authors: A. V. Kuznetsova, X. A. Glukhova, I. P. Beletsky, A. A. Ivanov
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
human natural killer cells
tumor microenvironment
extracellular matrix
new targets
anti-NK cell signaling
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2025.1609479/full
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