The Effect of Age on Fracture Risk: A Population-Based Cohort Study

Aim. To precisely estimate the effect of age on the risk of fracture hospitalisation among the Western Australia population over the life course. Methods. This population-based cohort study used hospital data on fractures for the period January 1991 to January 2013 among Western Australians born bet...

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Main Authors: Wenbin Liang, Tanya Chikritzhs
Format: Article
Language:English
Published: Wiley 2016-01-01
Series:Journal of Aging Research
Online Access:http://dx.doi.org/10.1155/2016/5071438
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author Wenbin Liang
Tanya Chikritzhs
author_facet Wenbin Liang
Tanya Chikritzhs
author_sort Wenbin Liang
collection DOAJ
description Aim. To precisely estimate the effect of age on the risk of fracture hospitalisation among the Western Australia population over the life course. Methods. This population-based cohort study used hospital data on fractures for the period January 1991 to January 2013 among Western Australians born between 1915 and 1990. Results. The average incidence rates (per 10,000 person-years) of fracture hospitalisation (95% confidence interval) were 50.12 (49.90, 50.35), 55.14 (54.82, 55.48), and 45.02 (44.71, 45.32) for both males and females, males only, and females only, respectively. The age-specific rate of fracture hospitalisation (in natural logarithm form) in adults (>18 years) was well predicted by age at its 1st, 2nd, and 3rd power in males with an adjusted R-squared of 0.98 and p<0.001. For females, the trend was also well predicted by its 1st and 2nd powers (the 3rd power term of age was removed due to its p value > 0.8) with an adjusted R-squared of 0.99 and p<0.001. Conclusions. Overall trends in age and gender specific risk of fracture among the Western Australian population were similar to estimates reported from previous studies. The trend in fracture hospitalisation risk over the life course can be almost fully explained by age.
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spelling doaj-art-45ad9811ea6a46aa9db744e5cd0c659b2025-02-03T05:51:35ZengWileyJournal of Aging Research2090-22042090-22122016-01-01201610.1155/2016/50714385071438The Effect of Age on Fracture Risk: A Population-Based Cohort StudyWenbin Liang0Tanya Chikritzhs1National Drug Research Institute, Curtin University, GPO Box U1987, Perth, WA 6845, AustraliaNational Drug Research Institute, Curtin University, GPO Box U1987, Perth, WA 6845, AustraliaAim. To precisely estimate the effect of age on the risk of fracture hospitalisation among the Western Australia population over the life course. Methods. This population-based cohort study used hospital data on fractures for the period January 1991 to January 2013 among Western Australians born between 1915 and 1990. Results. The average incidence rates (per 10,000 person-years) of fracture hospitalisation (95% confidence interval) were 50.12 (49.90, 50.35), 55.14 (54.82, 55.48), and 45.02 (44.71, 45.32) for both males and females, males only, and females only, respectively. The age-specific rate of fracture hospitalisation (in natural logarithm form) in adults (>18 years) was well predicted by age at its 1st, 2nd, and 3rd power in males with an adjusted R-squared of 0.98 and p<0.001. For females, the trend was also well predicted by its 1st and 2nd powers (the 3rd power term of age was removed due to its p value > 0.8) with an adjusted R-squared of 0.99 and p<0.001. Conclusions. Overall trends in age and gender specific risk of fracture among the Western Australian population were similar to estimates reported from previous studies. The trend in fracture hospitalisation risk over the life course can be almost fully explained by age.http://dx.doi.org/10.1155/2016/5071438
spellingShingle Wenbin Liang
Tanya Chikritzhs
The Effect of Age on Fracture Risk: A Population-Based Cohort Study
Journal of Aging Research
title The Effect of Age on Fracture Risk: A Population-Based Cohort Study
title_full The Effect of Age on Fracture Risk: A Population-Based Cohort Study
title_fullStr The Effect of Age on Fracture Risk: A Population-Based Cohort Study
title_full_unstemmed The Effect of Age on Fracture Risk: A Population-Based Cohort Study
title_short The Effect of Age on Fracture Risk: A Population-Based Cohort Study
title_sort effect of age on fracture risk a population based cohort study
url http://dx.doi.org/10.1155/2016/5071438
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