Genotypes of <i>Sechium</i> spp. as a Source of Natural Products with Biological Activity
The genus <i>Sechium</i> P. Br. (Cucurbitaceae) includes ten species, two of which are edible. The inedible genotypes are in a fragile ecological niche, since they are not used by rural inhabitants. A rescue and genetic crossing program was designed to identify uses that favor their cons...
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2024-12-01
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| author | Jorge Cadena-Iñiguez Ma. de Lourdes Arévalo-Galarza Edelmiro Santiago-Osorio Itzen Aguiñiga-Sánchez Jorge David Cadena-Zamudio Marcos Soto-Hernández Yeimy C. Ramírez-Rodas Lucero del Mar Ruiz-Posadas Sandra Salazar-Aguilar Víctor Manuel Cisneros-Solano |
| author_facet | Jorge Cadena-Iñiguez Ma. de Lourdes Arévalo-Galarza Edelmiro Santiago-Osorio Itzen Aguiñiga-Sánchez Jorge David Cadena-Zamudio Marcos Soto-Hernández Yeimy C. Ramírez-Rodas Lucero del Mar Ruiz-Posadas Sandra Salazar-Aguilar Víctor Manuel Cisneros-Solano |
| author_sort | Jorge Cadena-Iñiguez |
| collection | DOAJ |
| description | The genus <i>Sechium</i> P. Br. (Cucurbitaceae) includes ten species, two of which are edible. The inedible genotypes are in a fragile ecological niche, since they are not used by rural inhabitants. A rescue and genetic crossing program was designed to identify uses that favor their conservation due to their content of bioactive secondary metabolites (Sm) for health. Fruits of <i>S. compositum</i> (wild type), hybrid H-D Victor (inedible), and <i>S. edule</i> var<i>. nigrum spinosum</i> (edible) were evaluated by extraction methods such as juice and oven drying to determine the yields of Sm, with in vivo evaluations of liver damage. The dried biomass (40 °C) extracted with ethanolic and methanolic procedures showed lower Sm content than the juice (fresh biomass). More than 90% of phenolic acids and cucurbitacins in the extracts were degraded, possibly due to the drying time (oven). Biological activity showed that <i>nigrum spinosum</i> and HD-Victor have fewer toxic metabolites than <i>S. compositum</i>. The hybrid H-D Victor is of reduced cytotoxicity, showing the advantages of hybridization with wild types. Phytochemical and biological activity characterization may contribute to the conservation of genotypes and become a source of bioactive natural products. |
| format | Article |
| id | doaj-art-45a749dea79c42f9af0ed735a707dcc3 |
| institution | Kabale University |
| issn | 2075-1729 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj-art-45a749dea79c42f9af0ed735a707dcc32025-01-24T13:38:27ZengMDPI AGLife2075-17292024-12-011511510.3390/life15010015Genotypes of <i>Sechium</i> spp. as a Source of Natural Products with Biological ActivityJorge Cadena-Iñiguez0Ma. de Lourdes Arévalo-Galarza1Edelmiro Santiago-Osorio2Itzen Aguiñiga-Sánchez3Jorge David Cadena-Zamudio4Marcos Soto-Hernández5Yeimy C. Ramírez-Rodas6Lucero del Mar Ruiz-Posadas7Sandra Salazar-Aguilar8Víctor Manuel Cisneros-Solano9Colegio de Postgraduados, Campus San Luis Potosí, San Luis Potosí 78620, San Luis Potosí, MexicoInterdisciplinary Research Group at Sechium edule in Mexico, A.C., Agustin Melgar 10, Col. Niños Héroes, Texcoco 56160, Estado de México, MexicoInterdisciplinary Research Group at Sechium edule in Mexico, A.C., Agustin Melgar 10, Col. Niños Héroes, Texcoco 56160, Estado de México, MexicoInterdisciplinary Research Group at Sechium edule in Mexico, A.C., Agustin Melgar 10, Col. Niños Héroes, Texcoco 56160, Estado de México, MexicoInterdisciplinary Research Group at Sechium edule in Mexico, A.C., Agustin Melgar 10, Col. Niños Héroes, Texcoco 56160, Estado de México, MexicoInterdisciplinary Research Group at Sechium edule in Mexico, A.C., Agustin Melgar 10, Col. Niños Héroes, Texcoco 56160, Estado de México, MexicoInterdisciplinary Research Group at Sechium edule in Mexico, A.C., Agustin Melgar 10, Col. Niños Héroes, Texcoco 56160, Estado de México, MexicoInterdisciplinary Research Group at Sechium edule in Mexico, A.C., Agustin Melgar 10, Col. Niños Héroes, Texcoco 56160, Estado de México, MexicoInterdisciplinary Research Group at Sechium edule in Mexico, A.C., Agustin Melgar 10, Col. Niños Héroes, Texcoco 56160, Estado de México, MexicoInterdisciplinary Research Group at Sechium edule in Mexico, A.C., Agustin Melgar 10, Col. Niños Héroes, Texcoco 56160, Estado de México, MexicoThe genus <i>Sechium</i> P. Br. (Cucurbitaceae) includes ten species, two of which are edible. The inedible genotypes are in a fragile ecological niche, since they are not used by rural inhabitants. A rescue and genetic crossing program was designed to identify uses that favor their conservation due to their content of bioactive secondary metabolites (Sm) for health. Fruits of <i>S. compositum</i> (wild type), hybrid H-D Victor (inedible), and <i>S. edule</i> var<i>. nigrum spinosum</i> (edible) were evaluated by extraction methods such as juice and oven drying to determine the yields of Sm, with in vivo evaluations of liver damage. The dried biomass (40 °C) extracted with ethanolic and methanolic procedures showed lower Sm content than the juice (fresh biomass). More than 90% of phenolic acids and cucurbitacins in the extracts were degraded, possibly due to the drying time (oven). Biological activity showed that <i>nigrum spinosum</i> and HD-Victor have fewer toxic metabolites than <i>S. compositum</i>. The hybrid H-D Victor is of reduced cytotoxicity, showing the advantages of hybridization with wild types. Phytochemical and biological activity characterization may contribute to the conservation of genotypes and become a source of bioactive natural products.https://www.mdpi.com/2075-1729/15/1/15phytogenetic resourcesconservation of genotypessecondary metabolitesbiological activityextractionyields |
| spellingShingle | Jorge Cadena-Iñiguez Ma. de Lourdes Arévalo-Galarza Edelmiro Santiago-Osorio Itzen Aguiñiga-Sánchez Jorge David Cadena-Zamudio Marcos Soto-Hernández Yeimy C. Ramírez-Rodas Lucero del Mar Ruiz-Posadas Sandra Salazar-Aguilar Víctor Manuel Cisneros-Solano Genotypes of <i>Sechium</i> spp. as a Source of Natural Products with Biological Activity Life phytogenetic resources conservation of genotypes secondary metabolites biological activity extraction yields |
| title | Genotypes of <i>Sechium</i> spp. as a Source of Natural Products with Biological Activity |
| title_full | Genotypes of <i>Sechium</i> spp. as a Source of Natural Products with Biological Activity |
| title_fullStr | Genotypes of <i>Sechium</i> spp. as a Source of Natural Products with Biological Activity |
| title_full_unstemmed | Genotypes of <i>Sechium</i> spp. as a Source of Natural Products with Biological Activity |
| title_short | Genotypes of <i>Sechium</i> spp. as a Source of Natural Products with Biological Activity |
| title_sort | genotypes of i sechium i spp as a source of natural products with biological activity |
| topic | phytogenetic resources conservation of genotypes secondary metabolites biological activity extraction yields |
| url | https://www.mdpi.com/2075-1729/15/1/15 |
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