Follicular Helper T Cells in Systemic Lupus Erythematosus: Why Should They Be Considered as Interesting Therapeutic Targets?
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by B cell hyperactivity leading to the production of autoantibodies, some of which having a deleterious effect. Reducing autoantibody production thus represents a way of controlling lupus pathogenesis, and a better unde...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2016/5767106 |
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| _version_ | 1832557090958213120 |
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| author | Matthieu Sawaf Hélène Dumortier Fanny Monneaux |
| author_facet | Matthieu Sawaf Hélène Dumortier Fanny Monneaux |
| author_sort | Matthieu Sawaf |
| collection | DOAJ |
| description | Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by B cell hyperactivity leading to the production of autoantibodies, some of which having a deleterious effect. Reducing autoantibody production thus represents a way of controlling lupus pathogenesis, and a better understanding of the molecular and cellular factors involved in the differentiation of B cells into plasma cells could allow identifying new therapeutic targets. Follicular helper T cells (TFH) represent a distinct subset of CD4+ T cells specialized in providing help to B cells. They are required for the formation of germinal centers and the generation of long-lived serological memory and, as such, are suspected to play a central role in SLE. Recent advances in the field of TFH biology have allowed the identification of important molecular factors involved in TFH differentiation, regulation, and function. Interestingly, some of these TFH-related molecules have been described to be dysregulated in lupus patients. In the present review, we give an overview of the aberrant expression and/or function of such key players in lupus, and we highlight their potential as therapeutic targets. |
| format | Article |
| id | doaj-art-459ac49f37204db2b8c78dd64d65b615 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-459ac49f37204db2b8c78dd64d65b6152025-02-03T05:43:41ZengWileyJournal of Immunology Research2314-88612314-71562016-01-01201610.1155/2016/57671065767106Follicular Helper T Cells in Systemic Lupus Erythematosus: Why Should They Be Considered as Interesting Therapeutic Targets?Matthieu Sawaf0Hélène Dumortier1Fanny Monneaux2CNRS, Immunopathologie et Chimie Thérapeutique/Laboratory of Excellence MEDALIS, Institut de Biologie Moléculaire et Cellulaire, 67084 Strasbourg, FranceCNRS, Immunopathologie et Chimie Thérapeutique/Laboratory of Excellence MEDALIS, Institut de Biologie Moléculaire et Cellulaire, 67084 Strasbourg, FranceCNRS, Immunopathologie et Chimie Thérapeutique/Laboratory of Excellence MEDALIS, Institut de Biologie Moléculaire et Cellulaire, 67084 Strasbourg, FranceSystemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by B cell hyperactivity leading to the production of autoantibodies, some of which having a deleterious effect. Reducing autoantibody production thus represents a way of controlling lupus pathogenesis, and a better understanding of the molecular and cellular factors involved in the differentiation of B cells into plasma cells could allow identifying new therapeutic targets. Follicular helper T cells (TFH) represent a distinct subset of CD4+ T cells specialized in providing help to B cells. They are required for the formation of germinal centers and the generation of long-lived serological memory and, as such, are suspected to play a central role in SLE. Recent advances in the field of TFH biology have allowed the identification of important molecular factors involved in TFH differentiation, regulation, and function. Interestingly, some of these TFH-related molecules have been described to be dysregulated in lupus patients. In the present review, we give an overview of the aberrant expression and/or function of such key players in lupus, and we highlight their potential as therapeutic targets.http://dx.doi.org/10.1155/2016/5767106 |
| spellingShingle | Matthieu Sawaf Hélène Dumortier Fanny Monneaux Follicular Helper T Cells in Systemic Lupus Erythematosus: Why Should They Be Considered as Interesting Therapeutic Targets? Journal of Immunology Research |
| title | Follicular Helper T Cells in Systemic Lupus Erythematosus: Why Should They Be Considered as Interesting Therapeutic Targets? |
| title_full | Follicular Helper T Cells in Systemic Lupus Erythematosus: Why Should They Be Considered as Interesting Therapeutic Targets? |
| title_fullStr | Follicular Helper T Cells in Systemic Lupus Erythematosus: Why Should They Be Considered as Interesting Therapeutic Targets? |
| title_full_unstemmed | Follicular Helper T Cells in Systemic Lupus Erythematosus: Why Should They Be Considered as Interesting Therapeutic Targets? |
| title_short | Follicular Helper T Cells in Systemic Lupus Erythematosus: Why Should They Be Considered as Interesting Therapeutic Targets? |
| title_sort | follicular helper t cells in systemic lupus erythematosus why should they be considered as interesting therapeutic targets |
| url | http://dx.doi.org/10.1155/2016/5767106 |
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