Primary Cognitive Factors Impaired after Glioma Surgery and Associated Brain Regions
Previous studies have shown that cognitive impairments in patients with brain tumors are not severe. However, to preserve the postsurgical QOL of patients with brain tumors, it is important to identify “primary” cognitive functions and associated brain regions that are more vulnerable to cognitive i...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2020-01-01
|
| Series: | Behavioural Neurology |
| Online Access: | http://dx.doi.org/10.1155/2020/7941689 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832556329569353728 |
|---|---|
| author | Chiharu Niki Takatsune Kumada Takashi Maruyama Manabu Tamura Takakazu Kawamata Yoshihiro Muragaki |
| author_facet | Chiharu Niki Takatsune Kumada Takashi Maruyama Manabu Tamura Takakazu Kawamata Yoshihiro Muragaki |
| author_sort | Chiharu Niki |
| collection | DOAJ |
| description | Previous studies have shown that cognitive impairments in patients with brain tumors are not severe. However, to preserve the postsurgical QOL of patients with brain tumors, it is important to identify “primary” cognitive functions and associated brain regions that are more vulnerable to cognitive impairments following surgery. The objective of this study was to investigate primary cognitive factors affecting not only simple cognitive tasks but also several other cognitive tasks and associated brain regions. Patients with glioma in the left (n=33) and the right (n=21) hemisphere participated in the study. Seven neuropsychological tasks from five cognitive domains were conducted pre- and 6 months postoperation. Factor analyses were conducted to identify “primary” common cognitive functions affecting the task performance in left and right glioma groups. Next, lesion analyses were performed using voxel-based lesion-symptom mapping (VLSM) to identify critical brain regions related to impairments of the primary cognitive functions. Factor analysis revealed two primary cognitive components in each glioma group. The first cognitive component in the left glioma group affected the digit span forward and backward tasks and concept shifting and the letter-digit substitution tasks. VLSM analysis revealed significant regions from the posterior middle temporal gyri to the supramarginal gyrus. The second cognitive component affected verbal memory, and verbal fluency tasks and VLSM analysis indicated two different significant regions, the medial temporal regions and the middle temporal gyrus to the posterior parietal lobes. The first cognitive component in the right glioma group affected positive and negative factor loadings on the task, such that the positive cognitive component affected only the Stroop color-word task. VLSM related to deficits of the Stroop task revealed significant regions in the anterior medial frontal cortex. On the other hand, the negative component affected concept shifting, word fluency, and digit span forward tasks, and VLSM revealed significant regions in the right inferior frontal cortex. It is suggested that primary cognitive functions related to specific brain regions were possibly affected by glioma resection. |
| format | Article |
| id | doaj-art-458e2f81f0be46e2bcc69da1f5fbf618 |
| institution | Kabale University |
| issn | 0953-4180 1875-8584 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Behavioural Neurology |
| spelling | doaj-art-458e2f81f0be46e2bcc69da1f5fbf6182025-02-03T05:45:45ZengWileyBehavioural Neurology0953-41801875-85842020-01-01202010.1155/2020/79416897941689Primary Cognitive Factors Impaired after Glioma Surgery and Associated Brain RegionsChiharu Niki0Takatsune Kumada1Takashi Maruyama2Manabu Tamura3Takakazu Kawamata4Yoshihiro Muragaki5Institute of Advanced Biomedical Engineering and Science, Tokyo Women’s Medical University, Tokyo 162-8666, JapanGraduate School of Informatics, Kyoto University, Kyoto 606-8501, JapanInstitute of Advanced Biomedical Engineering and Science, Tokyo Women’s Medical University, Tokyo 162-8666, JapanInstitute of Advanced Biomedical Engineering and Science, Tokyo Women’s Medical University, Tokyo 162-8666, JapanDepartment of Neurosurgery, Tokyo Women’s Medical University, Tokyo 162-8666, JapanInstitute of Advanced Biomedical Engineering and Science, Tokyo Women’s Medical University, Tokyo 162-8666, JapanPrevious studies have shown that cognitive impairments in patients with brain tumors are not severe. However, to preserve the postsurgical QOL of patients with brain tumors, it is important to identify “primary” cognitive functions and associated brain regions that are more vulnerable to cognitive impairments following surgery. The objective of this study was to investigate primary cognitive factors affecting not only simple cognitive tasks but also several other cognitive tasks and associated brain regions. Patients with glioma in the left (n=33) and the right (n=21) hemisphere participated in the study. Seven neuropsychological tasks from five cognitive domains were conducted pre- and 6 months postoperation. Factor analyses were conducted to identify “primary” common cognitive functions affecting the task performance in left and right glioma groups. Next, lesion analyses were performed using voxel-based lesion-symptom mapping (VLSM) to identify critical brain regions related to impairments of the primary cognitive functions. Factor analysis revealed two primary cognitive components in each glioma group. The first cognitive component in the left glioma group affected the digit span forward and backward tasks and concept shifting and the letter-digit substitution tasks. VLSM analysis revealed significant regions from the posterior middle temporal gyri to the supramarginal gyrus. The second cognitive component affected verbal memory, and verbal fluency tasks and VLSM analysis indicated two different significant regions, the medial temporal regions and the middle temporal gyrus to the posterior parietal lobes. The first cognitive component in the right glioma group affected positive and negative factor loadings on the task, such that the positive cognitive component affected only the Stroop color-word task. VLSM related to deficits of the Stroop task revealed significant regions in the anterior medial frontal cortex. On the other hand, the negative component affected concept shifting, word fluency, and digit span forward tasks, and VLSM revealed significant regions in the right inferior frontal cortex. It is suggested that primary cognitive functions related to specific brain regions were possibly affected by glioma resection.http://dx.doi.org/10.1155/2020/7941689 |
| spellingShingle | Chiharu Niki Takatsune Kumada Takashi Maruyama Manabu Tamura Takakazu Kawamata Yoshihiro Muragaki Primary Cognitive Factors Impaired after Glioma Surgery and Associated Brain Regions Behavioural Neurology |
| title | Primary Cognitive Factors Impaired after Glioma Surgery and Associated Brain Regions |
| title_full | Primary Cognitive Factors Impaired after Glioma Surgery and Associated Brain Regions |
| title_fullStr | Primary Cognitive Factors Impaired after Glioma Surgery and Associated Brain Regions |
| title_full_unstemmed | Primary Cognitive Factors Impaired after Glioma Surgery and Associated Brain Regions |
| title_short | Primary Cognitive Factors Impaired after Glioma Surgery and Associated Brain Regions |
| title_sort | primary cognitive factors impaired after glioma surgery and associated brain regions |
| url | http://dx.doi.org/10.1155/2020/7941689 |
| work_keys_str_mv | AT chiharuniki primarycognitivefactorsimpairedaftergliomasurgeryandassociatedbrainregions AT takatsunekumada primarycognitivefactorsimpairedaftergliomasurgeryandassociatedbrainregions AT takashimaruyama primarycognitivefactorsimpairedaftergliomasurgeryandassociatedbrainregions AT manabutamura primarycognitivefactorsimpairedaftergliomasurgeryandassociatedbrainregions AT takakazukawamata primarycognitivefactorsimpairedaftergliomasurgeryandassociatedbrainregions AT yoshihiromuragaki primarycognitivefactorsimpairedaftergliomasurgeryandassociatedbrainregions |