Identification of MORF4L1 as an endogenous substrate of CRBN and its potential role as a therapeutic target in cancer

Identification of MORF4L1 as an endogenous substrate of CRBN and its potential role as a therapeutic target in cancer

Abstract The ubiquitin-proteasome system (UPS) is essential for cellular homeostasis, regulating the degradation of proteins involved in key processes such as cell cycle, apoptosis, and DNA repair. Dysregulation of the UPS is implicated in hepatocellular carcinoma (HCC), contributing to tumor progre...

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Bibliographic Details
Main Authors: Luyao Zhang, Shunfang Liu, Jingliang He, Zhongke Hu, Lan Zhu, Hongyi Huang, Qi Gao, Dan Wang, Lu Chen, Xingyu Zhang, Ruotong Liu, Jiayun Wang, Yizhuo Song, Kaile Zeng, Xiuming Li, Yulu Chen, Xun Zou, Shaojie Ma, Xiujun Wang, Guofeng Xu, Wei Liu, Bin Liu
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
MORF4L1
CRBN
CC-885
Ubiquitin-proteasome system
Hepatocellular carcinoma (HCC)
Protein degradation
Online Access:https://doi.org/10.1038/s41598-024-82941-3
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