Influence of lanthanum carbonate combined with different blood purification methods on mineral and bone disorders in patients with chronic kidney disease
Objective To observe the influence of lanthanum carbonate combined with three different kinds of blood purification methods on chronic kidney disease mineral and bone disorderCCKDMBD) in patients receiving maintenance hemodialysis（MHD） so as to provide the optimal treatment for and improve the quali...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | zho |
| Published: |
Editorial Department of Journal of Clinical Nephrology
2016-01-01
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| Series: | Linchuang shenzangbing zazhi |
| Subjects: | |
| Online Access: | http://www.lcszb.com/thesisDetails?columnId=57917124&Fpath=home&index=0 |
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| Summary: | Objective To observe the influence of lanthanum carbonate combined with three different kinds of blood purification methods on chronic kidney disease mineral and bone disorderCCKDMBD) in patients receiving maintenance hemodialysis（MHD） so as to provide the optimal treatment for and improve the quality of life of patients with CKD-MBD.Methods Seventy-six CKD-MBD patients given MHD were selected as the research objects in the Blood Purification Center of Shanxi Provincial People’s Hospital from January of 2014 to May of 2015.All patients were treated with lanthanum carbonate.They were randomly divided into three groups,including hemodialysis group（HD group,n = 24）,hemodialysis and hemodialysis filtration group（HD+ HDF group,n = 27）,hemodialysis and blood perfusion group（HD + HP group,n = 25）,and all patients were cured for three months.Then the levels of serum calcium,phosphate,parathyroid hormone（PTH） and the calciumphosphorus product were detected.The incidence of adverse reactions in the three groups were observed and compared.Results The levels of blood calcium in the three groups were increased after three months,but there was no statistically difference among three groups（P>0.05）.The blood phosphorus and calcium-phosphorus product in all patients after treatment was significantly decreased（P<0.05）,but there was no statistically difference between HD+ HDF and HD+ HP groups（P>0.05）.There was significant difference between HD+ HDF or HD+ HP and HD group（P<0.05）.The levels of serum PTH had no significant change in the HD group before and after treatment（P>0.05）,however the levels of serum PTH were significantly decreased in HD+ HDF group and HD +HP group after treatment（P<0.05）.There was no significant difference between HD+ HDF group and HD+ HP group（P>0.05）.The incidence of complications was 75%,18.51%and 32%in HD group,HD+ HDF group and HD + HP group respectively.The incidence of complications in HD group was significantly higher than that in HD + HDF group and HD + HP group（P < 0.05 for both）.The incidence of complications in HD+ HDF group was the lowest among the three groups.Conclusions The lanthanum carbonate combined with the different kinds of blood purification methods could effectively remove blood phosphorus.The effect of HD + HDF and HD + HP was better than HD.HD+ HDF and HD+ HP could effectively remove serum PTH,and there was little side effect,which was a best way to treat CKD-MBD in patients with MHD. |
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| ISSN: | 1671-2390 |