Proinflammatory transcriptomic and kinomic alterations in astrocytes derived from patients with familial Alzheimer's disease

Proinflammatory transcriptomic and kinomic alterations in astrocytes derived from patients with familial Alzheimer's disease

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by profound neuronal and cognitive decline, with increasing evidence implicating astrocyte dysfunction in disease pathology. While traditional therapeutic approaches have primarily targeted neurons, the crucial r...

Full description

Saved in:

Bibliographic Details
Main Authors:	Benjamin Siciliano, Nicholas D. Henkel, William G. Ryan V, Ali Sajid Imami, John M. Vergis, Chongchong Xu, Taylen O. Arvay, Smita Sahay, Priyanka Pulvender, Abdul-rizaq Hamoud, Chadwick Hales, Robert E. McCullumsmith, Zhexing Wen
Format:	Article
Language:	English
Published:	Elsevier 2025-08-01
Series:	Brain, Behavior, & Immunity - Health
Subjects:	Alzheimer's disease Familial Alzheimer's disease Astrocyte dysfunction Multiomic analysis Transcriptomics Kinomics
Online Access:	http://www.sciencedirect.com/science/article/pii/S2666354625001024
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Perturbation of Cell-Subtype Specific Active Kinome Networks in Schizophrenia
by: Ali Sajid Imami, et al.
Published: (2024-11-01)

Illuminating the dark kinome: utilizing multiplex peptide activity arrays to functionally annotate understudied kinases
by: Abdul-rizaq Hamoud, et al.
Published: (2024-10-01)

Positional distribution and conservation of major phosphorylated sites in the human kinome
by: Athira Perunelly Gopalakrishnan, et al.
Published: (2025-04-01)

Kinome-wide CRISPR-Cas9 screens revealed EXOSC10 as a positive regulator of TGF-β signaling
by: Dingding Wang, et al.
Published: (2024-12-01)

Identifying and exploiting combinatorial synthetic lethality by characterizing adaptive kinome rewiring of EGFRvIII-driven glioblastoma
by: Benjamin Lin, et al.
Published: (2025-06-01)

Data structures for compound promiscuity analysis: promiscuity cliffs, pathways and promiscuity hubs formed by inhibitors of the human kinome
by: Filip Miljković, et al.
Published: (2019-08-01)

Estimating progression of Alzheimer’s disease with extracellular vesicle-related multi-omics risk models
by: Xiao Zhang, et al.
Published: (2025-07-01)

Matrix stiffness-induced IKBKE and MAPK8 signaling drives a phenotypic switch from DCIS to invasive breast cancer
by: Feifei Yan, et al.
Published: (2025-06-01)

Statins regulate kinase signaling by causing changes in phosphorylation, rather than through changes in gene expression or direct inhibition: evidence in colorectal cancer
by: Francisco Alejandro Lagunas-Rangel, et al.
Published: (2025-08-01)

ROCK1 is a potential combinatorial drug target for BRAF mutant melanoma
by: Marjon A Smit, et al.
Published: (2014-12-01)

Heterogeneidade cognitiva na doença de Alzheimer Cognitive heterogeneity in Alzheimer's disease
by: Paulo Roberto De Brito-Marques, et al.
Published: (1995-09-01)

Last Resort? Rationale for Comprehensive Molecular Analysis in Treatment-Refractory R/M HNSCC: A Case Report of Remarkable Response to Sacituzumab Govitecan Following Molecular and Functional Characterization
by: Henrike Barbara Zech, et al.
Published: (2025-05-01)

Application of the revised criteria for diagnosis and staging of Alzheimer's disease: Drug development and clinical practice
by: Clifford R. Jack, et al.
Published: (2024-10-01)

Introduction to the forensic research via omics markers in environmental health vulnerable areas (FROM) study
by: Jung-Yeon Kwon, et al.
Published: (2024-07-01)

Erythrocyte phospho-signalling is dynamically altered during infection with Plasmodium falciparum
by: Jack D. Adderley, et al.
Published: (2020-09-01)

Tratamento da doença de Alzheimer: recomendações e sugestões do Departamento Científico de Neurologia Cognitiva e do Envelhecimento da Academia Brasileira de Neurologia Treatment of Alzheimer’s Disease: recommendations and suggestions of the Scientific Department of Cognitive Neurology and Aging of the Brazilian Academy of Neurology
by: Eliasz Engelhardt, et al.
Published: (2005-12-01)

New insight into the role of altered brain cholesterol metabolism in the pathogenesis of AD: A unifying cholesterol hypothesis and new therapeutic approach for AD
by: Xiaobo Yang, et al.
Published: (2025-05-01)

Combination therapy targeting Alzheimer's disease risk factors is associated with a significant delay in Alzheimer's disease–related cognitive decline
by: Yuan Shang, et al.
Published: (2025-01-01)

The role of astrocytes in Alzheimer’s disease: a bibliometric analysis
by: Xiaoqiong An, et al.
Published: (2024-11-01)

Aging2Cancer: an integrated resource for linking aging to tumor multi-omics data
by: Dahua Xu, et al.
Published: (2024-12-01)

EmptyDropsMultiome discriminates real cells from background in single-cell multiomics assays
by: Stathis Megas, et al.
Published: (2024-05-01)

Kinome Profiling
by: Maikel P. Peppelenbosch
Published: (2012-01-01)

Commentary on “Assessment of sodium-glucose cotransporter 2 inhibitors (SGLT2i) and other antidiabetic agents in Alzheimer’s disease: A population-based study”
by: Feng Chen, et al.
Published: (2025-05-01)

Alzheimer’s disease in family practice
by: Oppel B.W. Greeff
Published: (2009-10-01)

KRSA: An R package and R Shiny web application for an end-to-end upstream kinase analysis of kinome array data.
by: Erica A K DePasquale, et al.
Published: (2021-01-01)

The roles of microglia and astrocytes in neuroinflammation of Alzheimer’s disease
by: Jialin Han, et al.
Published: (2025-05-01)

Host-driven remodeling of rumen microbiota supports lactation metabolism in buffalo
by: Zixu Ding, et al.
Published: (2025-06-01)

Integrating Transcriptomic and Proteomic Data: IL‐27B as a Key Protein in the Development of Septic Cardiomyopathy—A Retrospective Study
by: Yifeng Mao, et al.
Published: (2025-05-01)

Alterações de linguagem nas fases iniciais da doença de Alzheimer Language impairment in the early stages of Alzheimer's disease
by: Karin Zazo Ortiz, et al.
Published: (2005-06-01)

Diagnostic disclosure of Alzheimer's disease in Brazil: a national survey of specialized physicians
by: Vitor Santos de Souza, et al.
Published: (2023-10-01)

Cerebrospinal Fluid Biomarkers of Alzheimer Disease
by: Kseniya V. Nevzorova, et al.
Published: (2025-06-01)

Alzheimer's disease in Brazilian elderly has a relation with homocysteine but not with MTHFR polymorphisms A doença de Alzheimer em idosos brasileiros tem relação com homocisteina mas não com polimorfismos MTHFR
by: Vanessa Cavalcante da Silva, et al.
Published: (2006-12-01)

Astrocytic lipid droplets contain MHCII and may act as cogs in the antigen presentation machinery
by: Chiara Beretta, et al.
Published: (2025-04-01)

Alzheimer’s Disease: In Vitro and In Vivo Evidence of Activation of the Plasma Bradykinin-Forming Cascade and Implications for Therapy
by: Allen P. Kaplan, et al.
Published: (2024-12-01)

Avaliação neuropsicológica adequada às demências
by: Paulo Roberto de Brito-Marques, et al.
Published: (1995-03-01)

Understanding Alzheimer disease
by: M. Vally, et al.
Published: (2019-04-01)

An uncommon variant of Alzheimer’s disease: Posterior cortical atrophy
by: Tasneem Bux, et al.
Published: (2025-05-01)

The “Alzheimer Village”: Assessment of Alzheimer's disease representations in the general population: A cross sectional phone survey
by: Marion Pech, et al.
Published: (2022-01-01)

Alzheimer's 100th anniversary of death and his contribution to a better understanding of Senile dementia
by: Eliasz Engelhardt, et al.
Published: (2015-02-01)

Systematic review and meta-analysis of microbiota-gut-astrocyte axis perturbation in neurodegeneration, brain injury, and mood disorders
by: Daniel E. Radford-Smith, et al.
Published: (2025-07-01)