Uncover the Underlying Mechanism of Drug-Induced Myopathy by Using Systems Biology Approaches
Drug-induced myopathy (DIM) is a rare side effect; however, the consequence could be fatal. There are few reports to systematically assess the underlying mechanism of DIM. In this study, we curated the comprehensive DIM drug list based on structured labeling products (SPLs) and carried out the analy...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | International Journal of Genomics |
| Online Access: | http://dx.doi.org/10.1155/2017/9264034 |
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| author | Dong Li Aixin Li Hairui Zhou Xi Wang Peng Li Sheng Bi Yang Teng |
| author_facet | Dong Li Aixin Li Hairui Zhou Xi Wang Peng Li Sheng Bi Yang Teng |
| author_sort | Dong Li |
| collection | DOAJ |
| description | Drug-induced myopathy (DIM) is a rare side effect; however, the consequence could be fatal. There are few reports to systematically assess the underlying mechanism of DIM. In this study, we curated the comprehensive DIM drug list based on structured labeling products (SPLs) and carried out the analysis based on chemical structure space, drug protein interaction, side effect space, and transcriptomic profiling space. Some key features are enriched from each of analysis. Specifically, the similarity of DIM drugs is more significant than random chance, which shows that the chemical structure could distinguish the DIM-positive drugs from negatives. The cytochrome P450 (CYP) was identified to be shared by DIM drugs, which indicated the important role of metabolism in DIM. Three pathways including pathways in cancer, MAPK signaling pathway, and GnRH signaling pathway enriched based on transcriptomic analysis may explain the underlying mechanism of DIM. Although the DIM is the current focus of the study, the proposed approaches could be applied to other toxicity assessments and facilitate the safety evaluation. |
| format | Article |
| id | doaj-art-455bd6679c2e4d1c9c0ff3bf3c5157e9 |
| institution | Kabale University |
| issn | 2314-436X 2314-4378 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Genomics |
| spelling | doaj-art-455bd6679c2e4d1c9c0ff3bf3c5157e92025-02-03T01:02:45ZengWileyInternational Journal of Genomics2314-436X2314-43782017-01-01201710.1155/2017/92640349264034Uncover the Underlying Mechanism of Drug-Induced Myopathy by Using Systems Biology ApproachesDong Li0Aixin Li1Hairui Zhou2Xi Wang3Peng Li4Sheng Bi5Yang Teng6First Affiliated Hospital of Jiamusi University, Jiamusi, Heilongjiang 154002, ChinaFirst Affiliated Hospital of Jiamusi University, Jiamusi, Heilongjiang 154002, ChinaJiamusi University, Jiamusi, Heilongjiang 154002, ChinaFirst Affiliated Hospital of Jiamusi University, Jiamusi, Heilongjiang 154002, ChinaJiamusi Central Hospital, Jiamusi, Heilongjiang 154002, ChinaFirst Affiliated Hospital of Jiamusi University, Jiamusi, Heilongjiang 154002, ChinaJiamusi University, Jiamusi, Heilongjiang 154002, ChinaDrug-induced myopathy (DIM) is a rare side effect; however, the consequence could be fatal. There are few reports to systematically assess the underlying mechanism of DIM. In this study, we curated the comprehensive DIM drug list based on structured labeling products (SPLs) and carried out the analysis based on chemical structure space, drug protein interaction, side effect space, and transcriptomic profiling space. Some key features are enriched from each of analysis. Specifically, the similarity of DIM drugs is more significant than random chance, which shows that the chemical structure could distinguish the DIM-positive drugs from negatives. The cytochrome P450 (CYP) was identified to be shared by DIM drugs, which indicated the important role of metabolism in DIM. Three pathways including pathways in cancer, MAPK signaling pathway, and GnRH signaling pathway enriched based on transcriptomic analysis may explain the underlying mechanism of DIM. Although the DIM is the current focus of the study, the proposed approaches could be applied to other toxicity assessments and facilitate the safety evaluation.http://dx.doi.org/10.1155/2017/9264034 |
| spellingShingle | Dong Li Aixin Li Hairui Zhou Xi Wang Peng Li Sheng Bi Yang Teng Uncover the Underlying Mechanism of Drug-Induced Myopathy by Using Systems Biology Approaches International Journal of Genomics |
| title | Uncover the Underlying Mechanism of Drug-Induced Myopathy by Using Systems Biology Approaches |
| title_full | Uncover the Underlying Mechanism of Drug-Induced Myopathy by Using Systems Biology Approaches |
| title_fullStr | Uncover the Underlying Mechanism of Drug-Induced Myopathy by Using Systems Biology Approaches |
| title_full_unstemmed | Uncover the Underlying Mechanism of Drug-Induced Myopathy by Using Systems Biology Approaches |
| title_short | Uncover the Underlying Mechanism of Drug-Induced Myopathy by Using Systems Biology Approaches |
| title_sort | uncover the underlying mechanism of drug induced myopathy by using systems biology approaches |
| url | http://dx.doi.org/10.1155/2017/9264034 |
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