Non-invasive tape sampling of tryptophan and kynurenine in relation to phenylalanine and tyrosine from melanoma and adjacent non-lesional skin: A pilot study.

Non-invasive tape sampling of tryptophan and kynurenine in relation to phenylalanine and tyrosine from melanoma and adjacent non-lesional skin: A pilot study.

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<h4>Purpose</h4>To evade immunosurveillance many cancers convert tryptophan (Trp) into kynurenine (Kyn), which induces immunotolerance and suppresses immune responses. Elevated Kyn amounts have been found in blood from patients with cutaneous melanoma. This study aimed to investigate whe...

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Main Authors: Skaidre Jankovskaja, Peter Spégel, Kari Nielsen, Sebastian Björklund, Jeremy Bost, Johan Engblom, Gustav Christensen, Oksana Rogova, Maxim Morin, Merete Haedersdal, Martin Malmsten, Chris D Anderson, Tautgirdas Ruzgas
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0326457
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https://doi.org/10.1371/journal.pone.0326457

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