Clinicopathologic profile of intra-abdominal follicular dendritic cell sarcoma: A study of three cases with a literature review
Follicular dendritic cell sarcoma (FDCS) is a rare tumor, which mainly originates from follicular dendritic cells (FDCs) in the lymph nodes. Sometimes FDCS can arise from outside the lymph nodes. FDCS is an extremely rare malignant tumor in intraperitoneal or retroperitoneal tissue. We gathered the...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-01-01
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| Series: | Indian Journal of Pathology and Microbiology |
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| Online Access: | https://journals.lww.com/10.4103/ijpm.ijpm_1089_21 |
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| author | Jianhong Yan Qi Wu Yuchang Hu Ting Nai |
| author_facet | Jianhong Yan Qi Wu Yuchang Hu Ting Nai |
| author_sort | Jianhong Yan |
| collection | DOAJ |
| description | Follicular dendritic cell sarcoma (FDCS) is a rare tumor, which mainly originates from follicular dendritic cells (FDCs) in the lymph nodes. Sometimes FDCS can arise from outside the lymph nodes. FDCS is an extremely rare malignant tumor in intraperitoneal or retroperitoneal tissue. We gathered the detailed clinical data of three patients diagnosed with FDCS in the abdomen. The clinical observations and histopathologic and immunohistochemical features of FDCS were analyzed. The patients included two men and one woman aged 55 ~ 61 years old. The mesentery of the small intestine and colon was involved in case 1, spleen in case 2, and retroperitoneal tissues in case 3. Two patients presented with abdominal masses, and one presented with no obvious symptoms. Histology showed ovoid to spindle neoplastic cells arranged in fascicles and storiforms with inflammatory infiltrate as well as whorled patterns in some areas. Immunohistochemical staining was positive for CD21, CD23, CD35, and SSTR2. FDCS exhibits no characteristic clinical manifestations. Morphologically, FDCS can have overlapping features with many other entities, leading to misdiagnosis. The use of histopathology supplemented with FDC markers, such as CD21, CD23, and CD35, is useful for diagnosis and differential diagnosis. |
| format | Article |
| id | doaj-art-454eae9521904e1184117fbecabbb6b4 |
| institution | Kabale University |
| issn | 0377-4929 0974-5130 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Pathology and Microbiology |
| spelling | doaj-art-454eae9521904e1184117fbecabbb6b42025-01-22T15:14:34ZengWolters Kluwer Medknow PublicationsIndian Journal of Pathology and Microbiology0377-49290974-51302023-01-0167119520010.4103/ijpm.ijpm_1089_21Clinicopathologic profile of intra-abdominal follicular dendritic cell sarcoma: A study of three cases with a literature reviewJianhong YanQi WuYuchang HuTing NaiFollicular dendritic cell sarcoma (FDCS) is a rare tumor, which mainly originates from follicular dendritic cells (FDCs) in the lymph nodes. Sometimes FDCS can arise from outside the lymph nodes. FDCS is an extremely rare malignant tumor in intraperitoneal or retroperitoneal tissue. We gathered the detailed clinical data of three patients diagnosed with FDCS in the abdomen. The clinical observations and histopathologic and immunohistochemical features of FDCS were analyzed. The patients included two men and one woman aged 55 ~ 61 years old. The mesentery of the small intestine and colon was involved in case 1, spleen in case 2, and retroperitoneal tissues in case 3. Two patients presented with abdominal masses, and one presented with no obvious symptoms. Histology showed ovoid to spindle neoplastic cells arranged in fascicles and storiforms with inflammatory infiltrate as well as whorled patterns in some areas. Immunohistochemical staining was positive for CD21, CD23, CD35, and SSTR2. FDCS exhibits no characteristic clinical manifestations. Morphologically, FDCS can have overlapping features with many other entities, leading to misdiagnosis. The use of histopathology supplemented with FDC markers, such as CD21, CD23, and CD35, is useful for diagnosis and differential diagnosis.https://journals.lww.com/10.4103/ijpm.ijpm_1089_21abdominal cavitydiagnosisextranodefollicular dendritic cell sarcomaimmunohistochemistry |
| spellingShingle | Jianhong Yan Qi Wu Yuchang Hu Ting Nai Clinicopathologic profile of intra-abdominal follicular dendritic cell sarcoma: A study of three cases with a literature review Indian Journal of Pathology and Microbiology abdominal cavity diagnosis extranode follicular dendritic cell sarcoma immunohistochemistry |
| title | Clinicopathologic profile of intra-abdominal follicular dendritic cell sarcoma: A study of three cases with a literature review |
| title_full | Clinicopathologic profile of intra-abdominal follicular dendritic cell sarcoma: A study of three cases with a literature review |
| title_fullStr | Clinicopathologic profile of intra-abdominal follicular dendritic cell sarcoma: A study of three cases with a literature review |
| title_full_unstemmed | Clinicopathologic profile of intra-abdominal follicular dendritic cell sarcoma: A study of three cases with a literature review |
| title_short | Clinicopathologic profile of intra-abdominal follicular dendritic cell sarcoma: A study of three cases with a literature review |
| title_sort | clinicopathologic profile of intra abdominal follicular dendritic cell sarcoma a study of three cases with a literature review |
| topic | abdominal cavity diagnosis extranode follicular dendritic cell sarcoma immunohistochemistry |
| url | https://journals.lww.com/10.4103/ijpm.ijpm_1089_21 |
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