The association of genetic polymorphisms in interleukin-1 receptors type 1 and type 2 with age-related hearing impairment in a Taiwanese population: a case control study
Abstract Background Age-related hearing impairment (ARHI) is a major disability among the elder population. Chronic inflammation is an important factor in the development of ARHI. Interleukin-1 (IL-1) plays a key role in inflammation and may be associated with ARHI. The aim of this study is to analy...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2020-04-01
|
| Series: | Journal of Otolaryngology - Head and Neck Surgery |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s40463-020-00410-z |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832568836880072704 |
|---|---|
| author | Ning-Chia Chang Hua-Ling Yang Chia-Yen Dai Wen-Yi Lin Hsun-Mo Wang Chen-Yu Chien Kuen-Yao Ho |
| author_facet | Ning-Chia Chang Hua-Ling Yang Chia-Yen Dai Wen-Yi Lin Hsun-Mo Wang Chen-Yu Chien Kuen-Yao Ho |
| author_sort | Ning-Chia Chang |
| collection | DOAJ |
| description | Abstract Background Age-related hearing impairment (ARHI) is a major disability among the elder population. Chronic inflammation is an important factor in the development of ARHI. Interleukin-1 (IL-1) plays a key role in inflammation and may be associated with ARHI. The aim of this study is to analyze the associations of single nucleotide polymorphisms (SNPs) of IL-1 receptor genes with ARHI in an elderly population in Taiwan. Method Participants ≥65 years of age were recruited for audiometric tests and genetic analyses. The bilateral pure-tone average (PTA) of high-tone hearing levels was calculated for ARHI evaluation. The associations of SNPs of the IL-1 receptor type 1 gene (IL1R1) (rs3917225 and rs2234650) and type 2 gene (IL1R2) (rs4141134 and rs2071008) with ARHI were analyzed in 182 ARHI-susceptible (case) and 176 ARHI-resistant (control) participants. Results The G allele of IL1R1 rs3917225 showed a decreased risk of ARHI after adjustments for sex, age, and noise exposure. The GG genotype of IL1R1 rs3917225 in all hereditary models and the TT genotype of IL1R2 rs2071008 in the recessive model also showed decreased risks of ARHI after adjustments. Conclusion These findings suggest that IL1R1 and IL1R2 polymorphisms may contribute to the decreased risk of ARHI in the elderly population. |
| format | Article |
| id | doaj-art-454bb291445a44d3a885c822a976d666 |
| institution | Kabale University |
| issn | 1916-0216 |
| language | English |
| publishDate | 2020-04-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of Otolaryngology - Head and Neck Surgery |
| spelling | doaj-art-454bb291445a44d3a885c822a976d6662025-02-03T00:22:58ZengSAGE PublishingJournal of Otolaryngology - Head and Neck Surgery1916-02162020-04-014911710.1186/s40463-020-00410-zThe association of genetic polymorphisms in interleukin-1 receptors type 1 and type 2 with age-related hearing impairment in a Taiwanese population: a case control studyNing-Chia Chang0Hua-Ling Yang1Chia-Yen Dai2Wen-Yi Lin3Hsun-Mo Wang4Chen-Yu Chien5Kuen-Yao Ho6Department of Otorhinolaryngology, School of Medicine, College of Medicine, Kaohsiung Medical UniversityDivision of Hepatobiliary and Pancreatic Medicine, Department of Internal Medicine, Kaohsiung Medical University HospitalDivision of Hepatobiliary and Pancreatic Medicine, Department of Internal Medicine, Kaohsiung Medical University HospitalHealth Management Center, Kaohsiung Municipal Siaogang HospitalDepartment of Otorhinolaryngology, Kaohsiung Municipal Siaogang HospitalDepartment of Otorhinolaryngology, School of Medicine, College of Medicine, Kaohsiung Medical UniversityDepartment of Otorhinolaryngology, School of Medicine, College of Medicine, Kaohsiung Medical UniversityAbstract Background Age-related hearing impairment (ARHI) is a major disability among the elder population. Chronic inflammation is an important factor in the development of ARHI. Interleukin-1 (IL-1) plays a key role in inflammation and may be associated with ARHI. The aim of this study is to analyze the associations of single nucleotide polymorphisms (SNPs) of IL-1 receptor genes with ARHI in an elderly population in Taiwan. Method Participants ≥65 years of age were recruited for audiometric tests and genetic analyses. The bilateral pure-tone average (PTA) of high-tone hearing levels was calculated for ARHI evaluation. The associations of SNPs of the IL-1 receptor type 1 gene (IL1R1) (rs3917225 and rs2234650) and type 2 gene (IL1R2) (rs4141134 and rs2071008) with ARHI were analyzed in 182 ARHI-susceptible (case) and 176 ARHI-resistant (control) participants. Results The G allele of IL1R1 rs3917225 showed a decreased risk of ARHI after adjustments for sex, age, and noise exposure. The GG genotype of IL1R1 rs3917225 in all hereditary models and the TT genotype of IL1R2 rs2071008 in the recessive model also showed decreased risks of ARHI after adjustments. Conclusion These findings suggest that IL1R1 and IL1R2 polymorphisms may contribute to the decreased risk of ARHI in the elderly population.http://link.springer.com/article/10.1186/s40463-020-00410-zAge-related hearing impairmentInterleukin-1 receptorSingle nucleotide polymorphism |
| spellingShingle | Ning-Chia Chang Hua-Ling Yang Chia-Yen Dai Wen-Yi Lin Hsun-Mo Wang Chen-Yu Chien Kuen-Yao Ho The association of genetic polymorphisms in interleukin-1 receptors type 1 and type 2 with age-related hearing impairment in a Taiwanese population: a case control study Journal of Otolaryngology - Head and Neck Surgery Age-related hearing impairment Interleukin-1 receptor Single nucleotide polymorphism |
| title | The association of genetic polymorphisms in interleukin-1 receptors type 1 and type 2 with age-related hearing impairment in a Taiwanese population: a case control study |
| title_full | The association of genetic polymorphisms in interleukin-1 receptors type 1 and type 2 with age-related hearing impairment in a Taiwanese population: a case control study |
| title_fullStr | The association of genetic polymorphisms in interleukin-1 receptors type 1 and type 2 with age-related hearing impairment in a Taiwanese population: a case control study |
| title_full_unstemmed | The association of genetic polymorphisms in interleukin-1 receptors type 1 and type 2 with age-related hearing impairment in a Taiwanese population: a case control study |
| title_short | The association of genetic polymorphisms in interleukin-1 receptors type 1 and type 2 with age-related hearing impairment in a Taiwanese population: a case control study |
| title_sort | association of genetic polymorphisms in interleukin 1 receptors type 1 and type 2 with age related hearing impairment in a taiwanese population a case control study |
| topic | Age-related hearing impairment Interleukin-1 receptor Single nucleotide polymorphism |
| url | http://link.springer.com/article/10.1186/s40463-020-00410-z |
| work_keys_str_mv | AT ningchiachang theassociationofgeneticpolymorphismsininterleukin1receptorstype1andtype2withagerelatedhearingimpairmentinataiwanesepopulationacasecontrolstudy AT hualingyang theassociationofgeneticpolymorphismsininterleukin1receptorstype1andtype2withagerelatedhearingimpairmentinataiwanesepopulationacasecontrolstudy AT chiayendai theassociationofgeneticpolymorphismsininterleukin1receptorstype1andtype2withagerelatedhearingimpairmentinataiwanesepopulationacasecontrolstudy AT wenyilin theassociationofgeneticpolymorphismsininterleukin1receptorstype1andtype2withagerelatedhearingimpairmentinataiwanesepopulationacasecontrolstudy AT hsunmowang theassociationofgeneticpolymorphismsininterleukin1receptorstype1andtype2withagerelatedhearingimpairmentinataiwanesepopulationacasecontrolstudy AT chenyuchien theassociationofgeneticpolymorphismsininterleukin1receptorstype1andtype2withagerelatedhearingimpairmentinataiwanesepopulationacasecontrolstudy AT kuenyaoho theassociationofgeneticpolymorphismsininterleukin1receptorstype1andtype2withagerelatedhearingimpairmentinataiwanesepopulationacasecontrolstudy AT ningchiachang associationofgeneticpolymorphismsininterleukin1receptorstype1andtype2withagerelatedhearingimpairmentinataiwanesepopulationacasecontrolstudy AT hualingyang associationofgeneticpolymorphismsininterleukin1receptorstype1andtype2withagerelatedhearingimpairmentinataiwanesepopulationacasecontrolstudy AT chiayendai associationofgeneticpolymorphismsininterleukin1receptorstype1andtype2withagerelatedhearingimpairmentinataiwanesepopulationacasecontrolstudy AT wenyilin associationofgeneticpolymorphismsininterleukin1receptorstype1andtype2withagerelatedhearingimpairmentinataiwanesepopulationacasecontrolstudy AT hsunmowang associationofgeneticpolymorphismsininterleukin1receptorstype1andtype2withagerelatedhearingimpairmentinataiwanesepopulationacasecontrolstudy AT chenyuchien associationofgeneticpolymorphismsininterleukin1receptorstype1andtype2withagerelatedhearingimpairmentinataiwanesepopulationacasecontrolstudy AT kuenyaoho associationofgeneticpolymorphismsininterleukin1receptorstype1andtype2withagerelatedhearingimpairmentinataiwanesepopulationacasecontrolstudy |