Effectiveness of a 2-dose varicella vaccination program in Changzhou, China, during the transitional period (2017–2022): a registry-based case-cohort study
Abstract Background The benefits of improving coverage and timeliness of varicella vaccination need to be quantified in countries where varicella vaccine (VarV) has not yet been included in national immunization programs. This longitudinal study analyzed the vaccine effectiveness (VE) of the varicel...
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2025-01-01
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| Online Access: | https://doi.org/10.1186/s12889-025-21348-9 |
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| author | Suting Xiong Changlei Han Dan Wu Xiaomeng Mi Peipei Zhang Han Gao Gan Cao Fang Yao Cong Chen Xufeng Lv |
| author_facet | Suting Xiong Changlei Han Dan Wu Xiaomeng Mi Peipei Zhang Han Gao Gan Cao Fang Yao Cong Chen Xufeng Lv |
| author_sort | Suting Xiong |
| collection | DOAJ |
| description | Abstract Background The benefits of improving coverage and timeliness of varicella vaccination need to be quantified in countries where varicella vaccine (VarV) has not yet been included in national immunization programs. This longitudinal study analyzed the vaccine effectiveness (VE) of the varicella vaccination program implemented in Changzhou City during the transitional period (2017–2022). Methods Using the Immunization Information System and National Notifiable Infectious Disease Surveillance System registry data, this retrospective case-cohort study assessed the VEs of varicella vaccination for Changzhou children born from 2016 to 2021. The subcohort was sampled using inverse probability weighting for the survival analysis design to evaluate the VEs under different dosages and cost types, eliminating confounding by age and location area. Sensitivity analysis for the exclusion part assessed the study's robustness. Results A total of 5,172 children (1.12%) were sampled to the subcohort for studies, including 2,299 cases. VEs significantly rose with each successive dose, reaching 82.54% and 97.91%. VEs were lower for the single-dose subgroups until 2020, with significant increases in VEs in all subgroups in 2020 and after that. Most children who did not benefit from the “1–4” Vaccination Program had lower VEs due to delayed vaccination. Conclusion Improving 2-dose VarV vaccine coverage and timely vaccination could enhance the immune barrier for susceptible children. During the transitional period, the “1–4” Vaccination Program of VarV positively impacted coverage and timeliness in Changzhou. |
| format | Article |
| id | doaj-art-454ab6c0bb6340e29245cd6b664086f0 |
| institution | Kabale University |
| issn | 1471-2458 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Public Health |
| spelling | doaj-art-454ab6c0bb6340e29245cd6b664086f02025-01-19T12:41:34ZengBMCBMC Public Health1471-24582025-01-0125111510.1186/s12889-025-21348-9Effectiveness of a 2-dose varicella vaccination program in Changzhou, China, during the transitional period (2017–2022): a registry-based case-cohort studySuting Xiong0Changlei Han1Dan Wu2Xiaomeng Mi3Peipei Zhang4Han Gao5Gan Cao6Fang Yao7Cong Chen8Xufeng Lv9Changzhou Center for Disease Control and PreventionChangzhou Center for Disease Control and PreventionChangzhou Center for Disease Control and PreventionChangzhou Center for Disease Control and PreventionChangzhou Center for Disease Control and PreventionChangzhou Center for Disease Control and PreventionChangzhou Center for Disease Control and PreventionChangzhou Center for Disease Control and PreventionChangzhou Center for Disease Control and PreventionChangzhou Center for Disease Control and PreventionAbstract Background The benefits of improving coverage and timeliness of varicella vaccination need to be quantified in countries where varicella vaccine (VarV) has not yet been included in national immunization programs. This longitudinal study analyzed the vaccine effectiveness (VE) of the varicella vaccination program implemented in Changzhou City during the transitional period (2017–2022). Methods Using the Immunization Information System and National Notifiable Infectious Disease Surveillance System registry data, this retrospective case-cohort study assessed the VEs of varicella vaccination for Changzhou children born from 2016 to 2021. The subcohort was sampled using inverse probability weighting for the survival analysis design to evaluate the VEs under different dosages and cost types, eliminating confounding by age and location area. Sensitivity analysis for the exclusion part assessed the study's robustness. Results A total of 5,172 children (1.12%) were sampled to the subcohort for studies, including 2,299 cases. VEs significantly rose with each successive dose, reaching 82.54% and 97.91%. VEs were lower for the single-dose subgroups until 2020, with significant increases in VEs in all subgroups in 2020 and after that. Most children who did not benefit from the “1–4” Vaccination Program had lower VEs due to delayed vaccination. Conclusion Improving 2-dose VarV vaccine coverage and timely vaccination could enhance the immune barrier for susceptible children. During the transitional period, the “1–4” Vaccination Program of VarV positively impacted coverage and timeliness in Changzhou.https://doi.org/10.1186/s12889-025-21348-9Varicella Vaccine (VarV)Vaccine Effectiveness (VE)Case Cohort study (CCS)Vaccination Program |
| spellingShingle | Suting Xiong Changlei Han Dan Wu Xiaomeng Mi Peipei Zhang Han Gao Gan Cao Fang Yao Cong Chen Xufeng Lv Effectiveness of a 2-dose varicella vaccination program in Changzhou, China, during the transitional period (2017–2022): a registry-based case-cohort study BMC Public Health Varicella Vaccine (VarV) Vaccine Effectiveness (VE) Case Cohort study (CCS) Vaccination Program |
| title | Effectiveness of a 2-dose varicella vaccination program in Changzhou, China, during the transitional period (2017–2022): a registry-based case-cohort study |
| title_full | Effectiveness of a 2-dose varicella vaccination program in Changzhou, China, during the transitional period (2017–2022): a registry-based case-cohort study |
| title_fullStr | Effectiveness of a 2-dose varicella vaccination program in Changzhou, China, during the transitional period (2017–2022): a registry-based case-cohort study |
| title_full_unstemmed | Effectiveness of a 2-dose varicella vaccination program in Changzhou, China, during the transitional period (2017–2022): a registry-based case-cohort study |
| title_short | Effectiveness of a 2-dose varicella vaccination program in Changzhou, China, during the transitional period (2017–2022): a registry-based case-cohort study |
| title_sort | effectiveness of a 2 dose varicella vaccination program in changzhou china during the transitional period 2017 2022 a registry based case cohort study |
| topic | Varicella Vaccine (VarV) Vaccine Effectiveness (VE) Case Cohort study (CCS) Vaccination Program |
| url | https://doi.org/10.1186/s12889-025-21348-9 |
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