Molecular Mechanisms Involved in Mesenchymal Stem Cell Migration to the Site of Acute Myocardial Infarction
Mesenchymal stem cells or multipotent mesenchymal stromal cells (both referred to as MSC) have been shown in some studies to have a beneficial effect on myocardial recovery after infarct. Current strategies for MSC delivery to heart involve intravenous, intraarterial, and intramuscular delivery. Dif...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2009-01-01
|
| Series: | International Journal of Cell Biology |
| Online Access: | http://dx.doi.org/10.1155/2009/904682 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832566752281624576 |
|---|---|
| author | Katarina Kollar Matthew M. Cook Kerry Atkinson Gary Brooke |
| author_facet | Katarina Kollar Matthew M. Cook Kerry Atkinson Gary Brooke |
| author_sort | Katarina Kollar |
| collection | DOAJ |
| description | Mesenchymal stem cells or multipotent mesenchymal stromal cells (both referred to as MSC) have been shown in some studies to have a beneficial effect on myocardial recovery after infarct. Current strategies for MSC delivery to heart involve intravenous, intraarterial, and intramuscular delivery. Different routes of MSC delivery and a lack of knowledge of the mechanisms that MSC utilise to migrate in vivo has most likely led to the marked variations in results that have been found. This review aims to summarise the current knowledge of MSC migratory mechanisms and looks to future methods of MSC manipulation prior to delivery in order to enhance MSC migration and engraftment. |
| format | Article |
| id | doaj-art-4535d2e60f1c4ca5b04f649e4065013e |
| institution | Kabale University |
| issn | 1687-8876 1687-8884 |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Cell Biology |
| spelling | doaj-art-4535d2e60f1c4ca5b04f649e4065013e2025-02-03T01:03:18ZengWileyInternational Journal of Cell Biology1687-88761687-88842009-01-01200910.1155/2009/904682904682Molecular Mechanisms Involved in Mesenchymal Stem Cell Migration to the Site of Acute Myocardial InfarctionKatarina Kollar0Matthew M. Cook1Kerry Atkinson2Gary Brooke3Adult Stem Cell Laboratory, Mater Medical Research Institute, South Brisbane, QLD 4101, AustraliaAdult Stem Cell Laboratory, Mater Medical Research Institute, South Brisbane, QLD 4101, AustraliaAdult Stem Cell Laboratory, Mater Medical Research Institute, South Brisbane, QLD 4101, AustraliaAdult Stem Cell Laboratory, Mater Medical Research Institute, South Brisbane, QLD 4101, AustraliaMesenchymal stem cells or multipotent mesenchymal stromal cells (both referred to as MSC) have been shown in some studies to have a beneficial effect on myocardial recovery after infarct. Current strategies for MSC delivery to heart involve intravenous, intraarterial, and intramuscular delivery. Different routes of MSC delivery and a lack of knowledge of the mechanisms that MSC utilise to migrate in vivo has most likely led to the marked variations in results that have been found. This review aims to summarise the current knowledge of MSC migratory mechanisms and looks to future methods of MSC manipulation prior to delivery in order to enhance MSC migration and engraftment.http://dx.doi.org/10.1155/2009/904682 |
| spellingShingle | Katarina Kollar Matthew M. Cook Kerry Atkinson Gary Brooke Molecular Mechanisms Involved in Mesenchymal Stem Cell Migration to the Site of Acute Myocardial Infarction International Journal of Cell Biology |
| title | Molecular Mechanisms Involved in Mesenchymal Stem Cell Migration to the Site of Acute Myocardial Infarction |
| title_full | Molecular Mechanisms Involved in Mesenchymal Stem Cell Migration to the Site of Acute Myocardial Infarction |
| title_fullStr | Molecular Mechanisms Involved in Mesenchymal Stem Cell Migration to the Site of Acute Myocardial Infarction |
| title_full_unstemmed | Molecular Mechanisms Involved in Mesenchymal Stem Cell Migration to the Site of Acute Myocardial Infarction |
| title_short | Molecular Mechanisms Involved in Mesenchymal Stem Cell Migration to the Site of Acute Myocardial Infarction |
| title_sort | molecular mechanisms involved in mesenchymal stem cell migration to the site of acute myocardial infarction |
| url | http://dx.doi.org/10.1155/2009/904682 |
| work_keys_str_mv | AT katarinakollar molecularmechanismsinvolvedinmesenchymalstemcellmigrationtothesiteofacutemyocardialinfarction AT matthewmcook molecularmechanismsinvolvedinmesenchymalstemcellmigrationtothesiteofacutemyocardialinfarction AT kerryatkinson molecularmechanismsinvolvedinmesenchymalstemcellmigrationtothesiteofacutemyocardialinfarction AT garybrooke molecularmechanismsinvolvedinmesenchymalstemcellmigrationtothesiteofacutemyocardialinfarction |