Biometallic ions and derivatives: a new direction for cancer immunotherapy
Abstract Biometallic ions play a crucial role in regulating the immune system. In recent years, cancer immunotherapy has become a breakthrough in cancer treatment, achieving good efficacy in a wide range of cancers with its specificity and durability advantages. However, existing therapies still fac...
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| Format: | Article |
| Language: | English |
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BMC
2025-01-01
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| Series: | Molecular Cancer |
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| Online Access: | https://doi.org/10.1186/s12943-025-02225-w |
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| _version_ | 1832594965978415104 |
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| author | Lin Zhao Yajun Gui Jing Cai Xiangying Deng |
| author_facet | Lin Zhao Yajun Gui Jing Cai Xiangying Deng |
| author_sort | Lin Zhao |
| collection | DOAJ |
| description | Abstract Biometallic ions play a crucial role in regulating the immune system. In recent years, cancer immunotherapy has become a breakthrough in cancer treatment, achieving good efficacy in a wide range of cancers with its specificity and durability advantages. However, existing therapies still face challenges, such as immune tolerance and immune escape. Biometallic ions (e.g. zinc, copper, magnesium, manganese, etc.) can assist in enhancing the efficacy of immunotherapy through the activation of immune cells, enhancement of tumor antigen presentation, and improvement of the tumor microenvironment. In addition, biometallic ions and derivatives can directly inhibit tumor cell progression and offer the possibility of effectively overcoming the limitations of current cancer immunotherapy by promoting immune responses and reducing immunosuppressive signals. This review explores the role and potential application prospects of biometallic ions in cancer immunotherapy, providing new ideas for future clinical application of metal ions as part of cancer immunotherapy and helping to guide the development of more effective and safe therapeutic regimens. |
| format | Article |
| id | doaj-art-453311842c9f4eedb83c81113b9d157d |
| institution | Kabale University |
| issn | 1476-4598 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Molecular Cancer |
| spelling | doaj-art-453311842c9f4eedb83c81113b9d157d2025-01-19T12:12:42ZengBMCMolecular Cancer1476-45982025-01-0124112510.1186/s12943-025-02225-wBiometallic ions and derivatives: a new direction for cancer immunotherapyLin Zhao0Yajun Gui1Jing Cai2Xiangying Deng3Department of Pathology, The Second Xiangya Hospital, Central South UniversityDepartment of Pathology, The Second Xiangya Hospital, Central South UniversityDepartment of Pathology, The Second Xiangya Hospital, Central South UniversityDepartment of Pathology, The Second Xiangya Hospital, Central South UniversityAbstract Biometallic ions play a crucial role in regulating the immune system. In recent years, cancer immunotherapy has become a breakthrough in cancer treatment, achieving good efficacy in a wide range of cancers with its specificity and durability advantages. However, existing therapies still face challenges, such as immune tolerance and immune escape. Biometallic ions (e.g. zinc, copper, magnesium, manganese, etc.) can assist in enhancing the efficacy of immunotherapy through the activation of immune cells, enhancement of tumor antigen presentation, and improvement of the tumor microenvironment. In addition, biometallic ions and derivatives can directly inhibit tumor cell progression and offer the possibility of effectively overcoming the limitations of current cancer immunotherapy by promoting immune responses and reducing immunosuppressive signals. This review explores the role and potential application prospects of biometallic ions in cancer immunotherapy, providing new ideas for future clinical application of metal ions as part of cancer immunotherapy and helping to guide the development of more effective and safe therapeutic regimens.https://doi.org/10.1186/s12943-025-02225-wMetalloimmunologyBiometallic ionsMetal materialsCancer immunotherapy |
| spellingShingle | Lin Zhao Yajun Gui Jing Cai Xiangying Deng Biometallic ions and derivatives: a new direction for cancer immunotherapy Molecular Cancer Metalloimmunology Biometallic ions Metal materials Cancer immunotherapy |
| title | Biometallic ions and derivatives: a new direction for cancer immunotherapy |
| title_full | Biometallic ions and derivatives: a new direction for cancer immunotherapy |
| title_fullStr | Biometallic ions and derivatives: a new direction for cancer immunotherapy |
| title_full_unstemmed | Biometallic ions and derivatives: a new direction for cancer immunotherapy |
| title_short | Biometallic ions and derivatives: a new direction for cancer immunotherapy |
| title_sort | biometallic ions and derivatives a new direction for cancer immunotherapy |
| topic | Metalloimmunology Biometallic ions Metal materials Cancer immunotherapy |
| url | https://doi.org/10.1186/s12943-025-02225-w |
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