Hydrogen Peroxide in Inflammation: Messenger, Guide, and Assassin
Starting as a model for developmental genetics, embryology, and organogenesis, the zebrafish has become increasingly popular as a model organism for numerous areas of biology and biomedicine over the last decades. Within haematology, this includes studies on blood cell development and function and t...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
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| Series: | Advances in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2012/541471 |
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| _version_ | 1832546725921816576 |
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| author | C. Wittmann P. Chockley S. K. Singh L. Pase G. J. Lieschke C. Grabher |
| author_facet | C. Wittmann P. Chockley S. K. Singh L. Pase G. J. Lieschke C. Grabher |
| author_sort | C. Wittmann |
| collection | DOAJ |
| description | Starting as a model for developmental genetics, embryology, and organogenesis, the zebrafish has become increasingly popular as a model organism for numerous areas of biology and biomedicine over the last decades. Within haematology, this includes studies on blood cell development and function and the intricate regulatory mechanisms within vertebrate immunity. Here, we review recent studies on the immediate mechanisms mounting an inflammatory response by in vivo analyses using the zebrafish. These recently revealed novel roles of the reactive oxygen species hydrogen peroxide that have changed our view on the initiation of a granulocytic inflammatory response. |
| format | Article |
| id | doaj-art-451d00f7d4eb4ad585b6cf46751ec849 |
| institution | Kabale University |
| issn | 1687-9104 1687-9112 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Hematology |
| spelling | doaj-art-451d00f7d4eb4ad585b6cf46751ec8492025-02-03T06:47:23ZengWileyAdvances in Hematology1687-91041687-91122012-01-01201210.1155/2012/541471541471Hydrogen Peroxide in Inflammation: Messenger, Guide, and AssassinC. Wittmann0P. Chockley1S. K. Singh2L. Pase3G. J. Lieschke4C. Grabher5Institute of Toxicology and Genetics, Karlsruhe Institute of Technology (KIT), 76133 Karlsruhe, GermanyInstitute of Toxicology and Genetics, Karlsruhe Institute of Technology (KIT), 76133 Karlsruhe, GermanyInstitute of Toxicology and Genetics, Karlsruhe Institute of Technology (KIT), 76133 Karlsruhe, GermanyCell Cycle and Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, East Melbourne, VIC 3002, AustraliaAustralian Regenerative Medicine Institute, Monash University, Clayton, VIC 3800, AustraliaInstitute of Toxicology and Genetics, Karlsruhe Institute of Technology (KIT), 76133 Karlsruhe, GermanyStarting as a model for developmental genetics, embryology, and organogenesis, the zebrafish has become increasingly popular as a model organism for numerous areas of biology and biomedicine over the last decades. Within haematology, this includes studies on blood cell development and function and the intricate regulatory mechanisms within vertebrate immunity. Here, we review recent studies on the immediate mechanisms mounting an inflammatory response by in vivo analyses using the zebrafish. These recently revealed novel roles of the reactive oxygen species hydrogen peroxide that have changed our view on the initiation of a granulocytic inflammatory response.http://dx.doi.org/10.1155/2012/541471 |
| spellingShingle | C. Wittmann P. Chockley S. K. Singh L. Pase G. J. Lieschke C. Grabher Hydrogen Peroxide in Inflammation: Messenger, Guide, and Assassin Advances in Hematology |
| title | Hydrogen Peroxide in Inflammation: Messenger, Guide, and Assassin |
| title_full | Hydrogen Peroxide in Inflammation: Messenger, Guide, and Assassin |
| title_fullStr | Hydrogen Peroxide in Inflammation: Messenger, Guide, and Assassin |
| title_full_unstemmed | Hydrogen Peroxide in Inflammation: Messenger, Guide, and Assassin |
| title_short | Hydrogen Peroxide in Inflammation: Messenger, Guide, and Assassin |
| title_sort | hydrogen peroxide in inflammation messenger guide and assassin |
| url | http://dx.doi.org/10.1155/2012/541471 |
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