Limbal Stem Cell Transplantation: Clinical Results, Limits, and Perspectives
Limbal stem cell deficiency (LSCD) is a clinical condition characterized by damage of cornea limbal stem cells, which results in an impairment of corneal epithelium turnover and in an invasion of the cornea by the conjunctival epithelium. In these patients, the conjunctivalization of the cornea is a...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2018-01-01
|
| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2018/8086269 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832562867975487488 |
|---|---|
| author | Marta Sacchetti Paolo Rama Alice Bruscolini Alessandro Lambiase |
| author_facet | Marta Sacchetti Paolo Rama Alice Bruscolini Alessandro Lambiase |
| author_sort | Marta Sacchetti |
| collection | DOAJ |
| description | Limbal stem cell deficiency (LSCD) is a clinical condition characterized by damage of cornea limbal stem cells, which results in an impairment of corneal epithelium turnover and in an invasion of the cornea by the conjunctival epithelium. In these patients, the conjunctivalization of the cornea is associated with visual impairment and cornea transplantation has poor prognosis for recurrence of the conjunctivalization. Current treatments of LSCD are aimed at replacing the damaged corneal stem cells in order to restore a healthy corneal epithelium. The autotransplantation of limbal tissue from the healthy, fellow eye is effective in unilateral LSCD but leads to depauperation of the stem cell reservoir. In the last decades, novel techniques such as cultivated limbal epithelial transplantation (CLET) have been proposed in order to reduce the damage of the healthy fellow eye. Clinical and experimental evidence showed that CLET is effective in inducing long-term regeneration of a healthy corneal epithelium in patients with LSCD with a success rate of 70%–80%. Current limitations for the treatment of LSCD are represented by the lack of a marker able to unequivocally identify limbal stem cells and the treatment of total, bilateral LSCD which requires other sources of stem cells for ocular surface reconstruction. |
| format | Article |
| id | doaj-art-4511ab437cf943beb630fce7dd9d4ad2 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-4511ab437cf943beb630fce7dd9d4ad22025-02-03T01:21:36ZengWileyStem Cells International1687-966X1687-96782018-01-01201810.1155/2018/80862698086269Limbal Stem Cell Transplantation: Clinical Results, Limits, and PerspectivesMarta Sacchetti0Paolo Rama1Alice Bruscolini2Alessandro Lambiase3Department of Sense Organs, Sapienza University of Rome, Rome, ItalyCornea and Ocular Surface Unit, San Raffaele Hospital, Milan, ItalyDepartment of Sense Organs, Sapienza University of Rome, Rome, ItalyDepartment of Sense Organs, Sapienza University of Rome, Rome, ItalyLimbal stem cell deficiency (LSCD) is a clinical condition characterized by damage of cornea limbal stem cells, which results in an impairment of corneal epithelium turnover and in an invasion of the cornea by the conjunctival epithelium. In these patients, the conjunctivalization of the cornea is associated with visual impairment and cornea transplantation has poor prognosis for recurrence of the conjunctivalization. Current treatments of LSCD are aimed at replacing the damaged corneal stem cells in order to restore a healthy corneal epithelium. The autotransplantation of limbal tissue from the healthy, fellow eye is effective in unilateral LSCD but leads to depauperation of the stem cell reservoir. In the last decades, novel techniques such as cultivated limbal epithelial transplantation (CLET) have been proposed in order to reduce the damage of the healthy fellow eye. Clinical and experimental evidence showed that CLET is effective in inducing long-term regeneration of a healthy corneal epithelium in patients with LSCD with a success rate of 70%–80%. Current limitations for the treatment of LSCD are represented by the lack of a marker able to unequivocally identify limbal stem cells and the treatment of total, bilateral LSCD which requires other sources of stem cells for ocular surface reconstruction.http://dx.doi.org/10.1155/2018/8086269 |
| spellingShingle | Marta Sacchetti Paolo Rama Alice Bruscolini Alessandro Lambiase Limbal Stem Cell Transplantation: Clinical Results, Limits, and Perspectives Stem Cells International |
| title | Limbal Stem Cell Transplantation: Clinical Results, Limits, and Perspectives |
| title_full | Limbal Stem Cell Transplantation: Clinical Results, Limits, and Perspectives |
| title_fullStr | Limbal Stem Cell Transplantation: Clinical Results, Limits, and Perspectives |
| title_full_unstemmed | Limbal Stem Cell Transplantation: Clinical Results, Limits, and Perspectives |
| title_short | Limbal Stem Cell Transplantation: Clinical Results, Limits, and Perspectives |
| title_sort | limbal stem cell transplantation clinical results limits and perspectives |
| url | http://dx.doi.org/10.1155/2018/8086269 |
| work_keys_str_mv | AT martasacchetti limbalstemcelltransplantationclinicalresultslimitsandperspectives AT paolorama limbalstemcelltransplantationclinicalresultslimitsandperspectives AT alicebruscolini limbalstemcelltransplantationclinicalresultslimitsandperspectives AT alessandrolambiase limbalstemcelltransplantationclinicalresultslimitsandperspectives |